Assessment of Structural Intolerance and Durability
General Structure Information 3ud1 ANK1 crystal structure of zu5a-zu5b domains of human erythrocyte ankyrin 2.0Å AUTH M.YASUNAGA,J.J.IPSARO,A.MONDRAGONTITL STRUCTURALLY SIMILAR BUT FUNCTIONALLY DIVERSE ZU5 DOMAINS INTITL 2 HUMAN ERYTHROCYTE ANKYRIN.REF J.MOL.BIOL. V. 417 336 2012REFN ISSN 0022-2836PMID 22310050DOI 10.1016/J.JMB.2012.01.041 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2h7t IGFBP2 solution structure of the c-terminal domain of insulin-like growth factor binding protein 2 (igfbp-2) -1.0Å AUTH Z.KUANG,S.YAO,D.W.KEIZER,C.C.WANG,L.A.BACH,AUTH 2 B.E.FORBES,J.C.WALLACE,R.S.NORTONTITL STRUCTURE, DYNAMICS AND HEPARIN BINDING OF THETITL 2 C-TERMINAL DOMAIN OF INSULIN-LIKE GROWTHTITL 3 FACTOR-BINDING PROTEIN-2 (IGFBP-2)REF J.MOL.BIOL. V. 364 690 2006REFN ISSN 0022-2836PMID 17020769DOI 10.1016/J.JMB.2006.09.006 Variant Set Distributions Mapped Variants
General Structure Information 4g1m ITGAV re-refinement of alpha v beta 3 structure 2.9Å AUTH X.DONG,L.Z.MI,J.ZHU,W.WANG,P.HU,B.H.LUO,T.A.SPRINGERTITL ALPHA V BETA 3 INTEGRIN CRYSTAL STRUCTURES AND THEIRTITL 2 FUNCTIONAL IMPLICATIONSREF BIOCHEMISTRY V. 51 8814 2012REFN ISSN 0006-2960PMID 23106217DOI 10.1021/BI300734N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1irh TFPI the solution structure of the third kunitz domain of tissue factor pathway inhibitor -1.0Å AUTH S.MINE,T.YAMAZAKI,T.MIYATA,S.HARA,H.KATOTITL STRUCTURAL MECHANISM FOR HEPARIN-BINDING OF THETITL 2 THIRD KUNITZ DOMAIN OF HUMAN TISSUE FACTOR PATHWAYTITL 3 INHIBITOR.REF BIOCHEMISTRY V. 41 78 2002REFN ISSN 0006-2960PMID 11772005DOI 10.1021/BI011299G Variant Set Distributions Mapped Variants
General Structure Information 1j8k FN1 nmr structure of the fibronectin eda domain, nmr, 20 structures -1.0Å AUTH T.NIIMI,M.OSAWA,N.YAMAJI,K.YASUNAGA,H.SAKASHITA,AUTH 2 T.MASE,A.TANAKA,S.FUJITATITL NMR STRUCTURE OF HUMAN FIBRONECTIN EDA.REF J.BIOMOL.NMR V. 21 281 2001REFN ISSN 0925-2738PMID 11775745DOI 10.1023/A:1012947209393 Variant Set Distributions Mapped Variants
General Structure Information 3ije ITGB3 crystal structure of the complete integrin alhavbeta3 ectodomain plus an alpha/beta transmembrane fragment 2.9Å AUTH J.P.XIONG,B.MAHALINGHAM,J.L.ALONSO,L.A.BORRELLI,X.RUI,AUTH 2 S.ANAND,B.T.HYMAN,T.RYSIOK,D.MULLER-POMPALLA,S.L.GOODMAN,AUTH 3 M.A.ARNAOUTTITL CRYSTAL STRUCTURE OF THE COMPLETE INTEGRIN ALPHAVBETA3TITL 2 ECTODOMAIN PLUS AN ALPHA/BETA TRANSMEMBRANE FRAGMENT.REF J.CELL BIOL. V. 186 589 2009REFN ISSN 0021-9525PMID 19704023DOI 10.1083/JCB.200905085 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2oct CSTB stefin b (cystatin b) tetramer 1.4Å AUTH S.JENKO KOKALJ,G.GUNCAR,I.STERN,G.MORGAN,S.RABZELJ,M.KENIG,AUTH 2 R.A.STANIFORTH,J.P.WALTHO,E.ZEROVNIK,D.TURKTITL ESSENTIAL ROLE OF PROLINE ISOMERIZATION IN STEFIN B TETRAMERTITL 2 FORMATION.REF J.MOL.BIOL. V. 366 1569 2007REFN ISSN 0022-2836PMID 17217964DOI 10.1016/J.JMB.2006.12.025 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dkk STAU1 the x-ray crystal structure of the human stau1 ssm-rbd5 domain- swapped dimer 1.7Å AUTH M.L.GLEGHORN,C.GONG,C.L.KIELKOPF,L.E.MAQUATTITL STAUFEN1 DIMERIZES THROUGH A CONSERVED MOTIF AND ATITL 2 DEGENERATE DSRNA-BINDING DOMAIN TO PROMOTE MRNA DECAY.REF NAT.STRUCT.MOL.BIOL. V. 20 515 2013REFN ISSN 1545-9993PMID 23524536DOI 10.1038/NSMB.2528 Variant Set Distributions Mapped Variants
General Structure Information 2dyq APBB3 crystal structure of the c-terminal phophotyrosine interaction domain of human apbb3 3.1Å AUTH S.SAIJO,A.NISHINO,S.KISHISHITA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE C-TERMINAL PHOPHOTYROSINETITL 2 INTERACTION DOMAIN OF HUMAN APBB3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4nt5 VWF crystal structure of human von willebrand factor ctck domain 3.28Å AUTH Y.F.ZHOU,T.A.SPRINGERTITL HIGHLY REINFORCED STRUCTURE OF A C-TERMINAL DIMERIZATIONTITL 2 DOMAIN IN VON WILLEBRAND FACTOR.REF BLOOD V. 123 1785 2014REFN ISSN 0006-4971PMID 24394662DOI 10.1182/BLOOD-2013-11-523639 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants