Assessment of Structural Intolerance and Durability
General Structure Information 2zv6 SERPINB3 crystal structure of human squamous cell carcinoma antigen 1 2.7Å AUTH B.ZHENG,Y.MATOBA,T.KUMAGAI,C.KATAGIRI,T.HIBINO,AUTH 2 M.SUGIYAMATITL CRYSTAL STRUCTURE OF SCCA1 AND INSIGHT ABOUT THETITL 2 INTERACTION WITH JNK1REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 380 143 2009REFN ISSN 0006-291XPMID 19166818DOI 10.1016/J.BBRC.2009.01.057 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3h5c PROZ x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Mapped Variants
General Structure Information 3fju CPA1 ascaris suum carboxypeptidase inhibitor in complex with human carboxypeptidase a1 1.6Å AUTH L.SANGLAS,F.X.AVILES,R.HUBER,F.X.GOMIS-RUTH,J.L.AROLASTITL MAMMALIAN METALLOPEPTIDASE INHIBITION AT THE DEFENSE BARRIERTITL 2 OF ASCARIS PARASITEREF PROC.NATL.ACAD.SCI.USA V. 106 1743 2009REFN ISSN 0027-8424PMID 19179285DOI 10.1073/PNAS.0812623106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jxd SPINK2 nmr structure of human serine protease inhibitor kazal type ii (spink2) -1.0Å AUTH T.CHEN,T.-R.LEE,W.-G.LIANG,W.-S.W.CHANG,P.-C.LYUTITL IDENTIFICATION OF TRYPSIN-INHIBITORY SITE ANDTITL 2 STRUCTURE DETERMINATION OF HUMAN SPINK2 SERINETITL 3 PROTEINASE INHIBITORREF PROTEINS V. 77 209 2009REFN ISSN 0887-3585PMID 19422058DOI 10.1002/PROT.22432 Variant Set Distributions Mapped Variants
General Structure Information 4ilw MMP10 complex of matrix metalloproteinase-10 catalytic domain (mmp-10cd) with tissue inhibitor of metalloproteinases-2 (timp-2) 2.1Å AUTH J.BATRA,A.S.SOARES,C.MEHNER,E.S.RADISKYTITL MATRIX METALLOPROTEINASE-10/TIMP-2 STRUCTURE AND ANALYSESTITL 2 DEFINE CONSERVED CORE INTERACTIONS AND DIVERSE EXOSITETITL 3 INTERACTIONS IN MMP/TIMP COMPLEXES.REF PLOS ONE V. 8 75836 2013REFN ESSN 1932-6203PMID 24073280DOI 10.1371/JOURNAL.PONE.0075836 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4dy0 SERPINE2 crystal structure of native protease nexin-1 with heparin 2.35Å AUTH W.LI,J.A.HUNTINGTONTITL CRYSTAL STRUCTURES OF PROTEASE NEXIN-1 IN COMPLEX WITHTITL 2 HEPARIN AND THROMBIN SUGGEST A 2-STEP RECOGNITION MECHANISM.REF BLOOD V. 120 459 2012REFN ISSN 0006-4971PMID 22618708DOI 10.1182/BLOOD-2012-03-415869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3kfq CTSV unreduced cathepsin v in complex with stefin a 1.99Å AUTH M.RENKO,D.TURKTITL UNREDUCED CATHEPSIN V IN COMPLEX WITH STEFIN AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dxc APBB1 crystal structure of the intracellular domain of human app in complex with fe65-ptb2 2.1Å AUTH J.RADZIMANOWSKI,B.SIMON,M.SATTLER,K.BEYREUTHER,AUTH 2 I.SINNING,K.WILDTITL STRUCTURE OF THE INTRACELLULAR DOMAIN OF THETITL 2 AMYLOID PRECURSOR PROTEIN IN COMPLEX WITHTITL 3 FE65-PTB2.REF EMBO REP. V. 9 1134 2008REFN ISSN 1469-221XPMID 18833287DOI 10.1038/EMBOR.2008.188 Variant Set Distributions Mapped Variants