3H5C.B | PROZ – ASTRID

3H5C.B | PROZ

General Structure Information

PDB ID	3h5c
HGNC Gene Label(s)	PROZ
Structure Name	x-ray structure of protein z-protein z inhibitor complex
Resolution	3.26Å
Reference	AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748

Variant Set Distributions

ExAC Variants

Number Of Residues	312
Number Of SNVs	98
Number Of Permutations	28121
Optimal Distance Threshold	12.0
K Statistic	0.084
p-value	0.78

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
13:113817331	rs372086805	P>A	B:50	(-90.10, 69.83, 21.41)
13:113817361	rs148844137	G>S	B:60	(-78.51, 72.36, 15.62)
13:113817392		T>N	B:70	(-87.02, 73.70, 12.95)
13:113817409	rs373383854	G>S	B:76	(-72.55, 71.55, 5.44)
13:113817412	rs375142480	Y>H	B:77	(-73.91, 69.02, 7.80)
13:113817413	COSM3711033	Y>C	B:77	(-73.91, 69.02, 7.80)
13:113818838		C>R	B:89	(-75.16, 60.58, -1.30)
13:113818847	COSM945558	E>Q	B:92	(-83.08, 59.31, 3.66)
13:113818848		E>G	B:92	(-83.08, 59.31, 3.66)
13:113818850		R>W	B:93	(-80.51, 64.10, 0.02)
13:113818854		T>I	B:94	(-86.28, 64.99, -0.32)
13:113818862		C>R	B:97	(-81.27, 64.09, -7.23)
13:113818869	rs544060188	H>R	B:99	(-83.18, 60.25, -12.27)
13:113818875		C>S	B:101	(-76.07, 60.93, -7.15)
13:113818877		L>F	B:102	(-71.69, 61.67, -8.14)
13:113818899		T>I	B:109	(-73.47, 65.72, -8.97)
13:113818907	rs373848983	C>R	B:112	(-80.08, 61.90, -16.14)
13:113818928	rs375926497	G>C	B:119	(-82.42, 71.65, -15.68)
13:113818931		E>K	B:120	(-82.66, 76.23, -14.52)
13:113818934		D>H	B:121	(-82.61, 72.56, -10.80)
13:113818944		Q>L	B:124	(-85.40, 68.44, -11.76)
13:113818946		C>G	B:125	(-84.91, 65.08, -14.94)
13:113818950		V>A	B:126	(-86.27, 67.00, -18.30)
13:113819371	rs369206122	Q>H	B:130	(-89.33, 61.37, -26.89)
13:113819375		A>S	B:132	(-88.10, 58.33, -21.26)
13:113819381	COSM1263155	G>R	B:134	(-92.90, 57.11, -19.12)
13:113819388		L>P	B:136	(-99.39, 57.71, -19.66)
13:113819393		S>P	B:138	(-102.19, 55.06, -15.86)
13:113819394		S>C	B:138	(-102.19, 55.06, -15.86)
13:113819398	rs201874723	E>D	B:139	(-103.82, 53.55, -12.89)
13:113819402	rs142314013	R>C	B:141	(-104.25, 47.29, -9.87)
13:113819403		R>H	B:141	(-104.25, 47.29, -9.87)
13:113819406		A>V	B:142	(-106.66, 44.73, -10.39)
13:113819421		D>A	B:147	(-101.54, 49.41, -19.71)
13:113819422		D>E	B:147	(-101.54, 49.41, -19.71)
13:113819427	rs563368891	P>L	B:149	(-95.08, 50.71, -22.74)
13:113819432		Q>K	B:151	(-93.94, 44.11, -21.42)
13:113824735	rs373519063	L>F	B:154	(-91.01, 36.68, -27.87)
13:113824745	rs143024570	E>K	B:158	(-95.22, 29.28, -35.43)
13:113824769		V>I	B:166	(-88.08, 44.56, -21.99)
13:113824772		I>V	B:167	(-88.71, 47.92, -24.82)
13:113824774		I>M	B:167	(-88.71, 47.92, -24.82)
13:113824776		I>T	B:168	(-83.89, 48.43, -23.11)
13:113824779	rs538052600	R>Q	B:169	(-81.83, 51.52, -25.50)
13:113824782		E>G	B:170	(-85.22, 53.01, -30.69)
13:113824800	rs200554916	T>I	B:176	(-83.89, 35.13, -21.18)
13:113824808		C>R	B:179	(-85.56, 32.09, -24.53)
13:113824809		C>Y	B:179	(-85.56, 32.09, -24.53)
13:113824818		L>S	B:182	(-85.72, 28.23, -27.87)
13:113824820		H>N	B:183	(-87.33, 29.07, -31.16)
13:113824821		H>R	B:183	(-87.33, 29.07, -31.16)
13:113824824		R>M	B:184	(-82.66, 30.01, -36.59)
13:113825910	rs138237894	F>V	B:192	(-98.94, 50.47, -25.91)
13:113825920		T>M	B:195	(-106.85, 46.53, -32.04)
13:113825922		S>G	B:196	(-106.61, 42.61, -29.97)
13:113825925	rs144364121	Q>K	B:197	(-106.79, 41.90, -33.56)
13:113825932		P>L	B:199	(-100.67, 42.68, -33.27)
13:113825939		M>I	B:201	(-95.40, 41.88, -35.64)
13:113825955	rs140132416	V>I	B:207	(-79.25, 37.43, -30.92)
13:113825961		V>L	B:209	(-75.85, 36.15, -26.13)
13:113825968	rs375788866	M>T	B:211	(-69.97, 37.70, -22.96)
13:113825970	rs143760342	R>W	B:212	(-68.23, 36.15, -20.11)
13:113825971	rs141140968	R>Q	B:212	(-68.23, 36.15, -20.11)
13:113825976		D>N	B:214	(-73.08, 28.91, -17.89)
13:113825980	rs371410022	A>V	B:215	(-76.52, 27.36, -18.73)
13:113825985	rs189464617	A>T	B:217	(-74.71, 28.01, -13.91)
13:113825986		A>V	B:217	(-74.71, 28.01, -13.91)
13:113825988		G>R	B:218	(-77.32, 30.15, -14.64)
13:113825992	rs146398692	E>V	B:219	(-73.65, 32.11, -14.60)
13:113825994		N>D	B:220	(-74.71, 35.83, -17.03)
13:113826035		C>W	B:233	(-91.84, 56.35, -29.69)
13:113826040	rs139742813	G>D	B:235	(-97.02, 54.95, -29.42)
13:113826043	COSM4046172	A>V	B:236	(-95.87, 51.85, -30.25)
13:113826051		P>A	B:239	(-88.41, 52.72, -23.62)
13:113826066	rs371908264	E>K	B:244	(-76.36, 53.37, -11.03)
13:113826078	rs199645640	A>T	B:248	(-80.60, 50.25, -7.64)
13:113826086		H>Q	B:250	(-77.83, 51.55, -1.89)
13:113826087	rs114412052	L>F	B:251	(-82.87, 54.38, -3.59)
13:113826090	rs140236962	L>F	B:252	(-84.87, 51.50, -6.12)
13:113826099	rs149903852	R>C	B:255	(-85.87, 53.33, 0.14)
13:113826105		R>G	B:257	(-93.89, 48.42, -2.44)
13:113826114		L>F	B:260	(-93.80, 40.66, -11.56)
13:113826120	rs370826050	G>S	B:262	(-96.57, 39.32, -17.18)
13:113826126		A>T	B:264	(-98.90, 32.74, -17.52)
13:113826129	rs200894631	R>C	B:265	(-97.38, 29.46, -18.55)
13:113826163	rs200473651 COSM173548	T>M	B:276	(-99.49, 43.01, -12.53)
13:113826165		R>W	B:277	(-99.35, 39.76, -8.86)
13:113826166	rs375825673	R>Q	B:277	(-99.35, 39.76, -8.86)
13:113826171	rs559556240	V>I	B:279	(-92.74, 42.46, -5.38)
13:113826192		E>Q	B:286	(-84.49, 34.51, 4.20)
13:113826195		C>R	B:287	(-83.87, 32.81, -0.46)
13:113826198		G>R	B:288	(-82.04, 29.86, 0.12)
13:113826202		Q>R	B:289	(-82.49, 27.78, 2.99)
13:113826252		V>M	B:306	(-99.53, 35.21, -5.24)
13:113826255	rs372138561	A>T	B:307	(-99.97, 31.55, -6.30)
13:113826256		A>V	B:307	(-99.97, 31.55, -6.30)
13:113826272	rs376510674	M>I	B:312	(-93.12, 33.80, -18.44)
13:113826275		D>E	B:313	(-89.17, 33.14, -18.86)
13:113826301		R>K	B:322	(-88.03, 61.14, -7.08)
13:113826319		T>M	B:328	(-85.05, 45.78, -11.05)
13:113826334	rs141423743	S>L	B:333	(-86.17, 29.64, -14.73)
13:113826343	rs370029811	V>G	B:336	(-87.71, 23.77, -8.72)
13:113826358	COSM695935	H>P	B:341	(-94.19, 32.66, -2.25)
13:113826373		T>I	B:346	(-81.51, 38.64, -13.23)
13:113826376	rs143678466	K>R	B:347	(-78.81, 42.01, -9.85)
13:113826387	rs374057161	Y>H	B:351	(-75.82, 42.43, -16.39)
13:113826399		F>I	B:355	(-77.04, 46.88, -21.32)
13:113826405	rs202097128	Q>E	B:357	(-69.84, 48.21, -24.98)
13:113826412		M>K	B:359	(-77.08, 49.21, -27.16)
13:113826415		N>S	B:360	(-73.50, 51.91, -28.52)