Assessment of Structural Intolerance and Durability
General Structure Information 2kg5 ARAP3 nmr solution structure of arap3-sam -1.0Å AUTH M.LEONE,J.CELLITTI,M.PELLECCHIATITL THE SAM DOMAIN OF THE LIPID PHOSPHATASE SHIP2TITL 2 ADOPTS A COMMON MODEL TO INTERACT WITH ARAP3-SAMTITL 3 AND EPHA2-SAM.REF BMC STRUCT.BIOL. V. 9 59 2009REFN ESSN 1472-6807PMID 19765305DOI 10.1186/1472-6807-9-59 Variant Set Distributions Mapped Variants
General Structure Information 2w4r DHX58 crystal structure of the regulatory domain of human lgp2 2.6Å AUTH D.A.PIPPIG,J.C.HELLMUTH,S.CUI,A.KIRCHHOFER,AUTH 2 K.LAMMENS,A.LAMMENS,A.SCHMIDT,S.ROTHENFUSSER,AUTH 3 K.P.HOPFNERTITL THE REGULATORY DOMAIN OF THE RIG-I FAMILY ATPASETITL 2 LGP2 SENSES DOUBLE-STRANDED RNA.REF NUCLEIC ACIDS RES. V. 37 2014 2009REFN ISSN 0305-1048PMID 19208642DOI 10.1093/NAR/GKP059 Variant Set Distributions Mapped Variants
General Structure Information 2vt8 PSMF1 structure of a conserved dimerisation domain within fbox7 and pi31 2.6Å AUTH R.J.KIRK,H.LAMAN,P.P.KNOWLES,J.MURRAY-RUST,AUTH 2 M.LOMONOSOV,E.K.MEZIANE,N.Q.MCDONALDTITL STRUCTURE OF A CONSERVED DIMERIZATION DOMAINTITL 2 WITHIN THE F-BOX PROTEIN FBXO7 AND THE PI31TITL 3 PROTEASOME INHIBITOR.REF J.BIOL.CHEM. V. 283 22325 2008REFN ISSN 0021-9258PMID 18495667DOI 10.1074/JBC.M709900200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2rnx KAT2B the structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human transcriptional co-activators pcaf and cbp -1.0Å AUTH L.ZENG,Q.ZHANG,G.GERONA-NAVARRO,N.MOSHKINA,M.M.ZHOUTITL STRUCTURAL BASIS OF SITE-SPECIFIC HISTONETITL 2 RECOGNITION BY THE BROMODOMAINS OF HUMANTITL 3 COACTIVATORS PCAF AND CBP/P300REF STRUCTURE V. 16 643 2008REFN ISSN 0969-2126PMID 18400184DOI 10.1016/J.STR.2008.01.010 Variant Set […]
General Structure Information 3g9v IL22RA2 crystal structure of a soluble decoy receptor il-22bp bound to interleukin-22 2.76Å AUTH P.R.DE MOURA,L.WATANABE,L.BLEICHER,D.COLAU,AUTH 2 L.DUMOUTIER,M.M.LEMAIRE,J.-C.RENAULD,I.POLIKARPOVTITL CRYSTAL STRUCTURE OF A SOLUBLE DECOY RECEPTORTITL 2 IL-22BP BOUND TO INTERLEUKIN-22REF FEBS LETT. V. 583 1072 2009REFN ISSN 0014-5793PMID 19285080DOI 10.1016/J.FEBSLET.2009.03.006 Variant Set Distributions Mapped Variants
General Structure Information 3ddt TRIM63 crystal structure of the b2 box from murf1 in dimeric state 1.9Å AUTH M.MROSEK,S.MEIER,Z.UCURUM-FOTIADIS,E.VON CASTELMUR,AUTH 2 E.HEDBOM,A.LUSTIG,S.GRZESIEK,D.LABEIT,S.LABEIT,AUTH 3 O.MAYANSTITL STRUCTURAL ANALYSIS OF B-BOX 2 FROM MURF1:TITL 2 IDENTIFICATION OF A NOVEL SELF-ASSOCIATION PATTERNTITL 3 IN A RING-LIKE FOLDREF BIOCHEMISTRY V. 47 10722 2008REFN ISSN 0006-2960PMID 18795805DOI 10.1021/BI800733Z Variant Set Distributions […]
General Structure Information 3bl7 DCPS synthetic gene encoded dcps bound to inhibitor dg156844 2.31Å AUTH J.SINGH,M.SALCIUS,S.W.LIU,B.L.STAKER,R.MISHRA,AUTH 2 J.THURMOND,G.MICHAUD,D.R.MATTOON,J.PRINTEN,AUTH 3 J.CHRISTENSEN,J.M.BJORNSSON,B.A.POLLOK,M.KILEDJIAN,AUTH 4 L.STEWART,J.JARECKI,M.E.GURNEYTITL DCPS AS A THERAPEUTIC TARGET FOR SPINAL MUSCULARTITL 2 ATROPHY.REF ACS CHEM.BIOL. V. 3 711 2008REFN ISSN 1554-8929PMID 18839960DOI 10.1021/CB800120T Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2r02 PDCD6IP crystal structure of alix/aip1 in complex with the hiv-1 ypltsl late domain 2.6Å AUTH Q.ZHAI,R.D.FISHER,H.Y.CHUNG,D.G.MYSZKA,AUTH 2 W.I.SUNDQUIST,C.P.HILLTITL STRUCTURAL AND FUNCTIONAL STUDIES OF ALIXTITL 2 INTERACTIONS WITH YPX(N)L LATE DOMAINS OF HIV-1TITL 3 AND EIAV.REF NAT.STRUCT.MOL.BIOL. V. 15 43 2008REFN ISSN 1545-9993PMID 18066081DOI 10.1038/NSMB1319 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3i4r NUP133 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3c0y HDAC7 crystal structure of catalytic domain of human histone deacetylase hdac7 2.1Å AUTH A.SCHUETZ,J.MIN,A.ALLALI-HASSANI,M.SCHAPIRA,AUTH 2 M.SHUEN,P.LOPPNAU,R.MAZITSCHEK,N.P.KWIATKOWSKI,AUTH 3 T.A.LEWIS,R.L.MAGLATHIN,T.H.MCLEAN,A.BOCHKAREV,AUTH 4 A.N.PLOTNIKOV,M.VEDADI,C.H.ARROWSMITHTITL HUMAN HDAC7 HARBORS A CLASS IIA HISTONETITL 2 DEACETYLASE-SPECIFIC ZINC BINDING MOTIF AND CRYPTICTITL 3 DEACETYLASE ACTIVITY.REF J.BIOL.CHEM. V. 283 11355 2008REFN ISSN 0021-9258PMID 18285338DOI 10.1074/JBC.M707362200 Variant Set Distributions Mapped Variants