Assessment of Structural Intolerance and Durability
General Structure Information 3lui SNX17 crystal structure of the snx17 px domain with bound sulphate 1.8Å AUTH R.GHAI,M.MOBLI,S.J.NORWOOD,A.BUGARCIC,R.D.TEASDALE,G.F.KING,AUTH 2 B.M.COLLINSTITL PHOX HOMOLOGY BAND 4.1/EZRIN/RADIXIN/MOESIN-LIKE PROTEINSTITL 2 FUNCTION AS MOLECULAR SCAFFOLDS THAT INTERACT WITH CARGOTITL 3 RECEPTORS AND RAS GTPASESREF PROC.NATL.ACAD.SCI.USA 2011REFN ESSN 1091-6490PMID 21512128DOI 10.1073/PNAS.1017110108 Variant Set Distributions Mapped Variants
General Structure Information 3lui SNX17 crystal structure of the snx17 px domain with bound sulphate 1.8Å AUTH R.GHAI,M.MOBLI,S.J.NORWOOD,A.BUGARCIC,R.D.TEASDALE,G.F.KING,AUTH 2 B.M.COLLINSTITL PHOX HOMOLOGY BAND 4.1/EZRIN/RADIXIN/MOESIN-LIKE PROTEINSTITL 2 FUNCTION AS MOLECULAR SCAFFOLDS THAT INTERACT WITH CARGOTITL 3 RECEPTORS AND RAS GTPASESREF PROC.NATL.ACAD.SCI.USA 2011REFN ESSN 1091-6490PMID 21512128DOI 10.1073/PNAS.1017110108 Variant Set Distributions Mapped Variants
General Structure Information 3lui SNX17 crystal structure of the snx17 px domain with bound sulphate 1.8Å AUTH R.GHAI,M.MOBLI,S.J.NORWOOD,A.BUGARCIC,R.D.TEASDALE,G.F.KING,AUTH 2 B.M.COLLINSTITL PHOX HOMOLOGY BAND 4.1/EZRIN/RADIXIN/MOESIN-LIKE PROTEINSTITL 2 FUNCTION AS MOLECULAR SCAFFOLDS THAT INTERACT WITH CARGOTITL 3 RECEPTORS AND RAS GTPASESREF PROC.NATL.ACAD.SCI.USA 2011REFN ESSN 1091-6490PMID 21512128DOI 10.1073/PNAS.1017110108 Variant Set Distributions Mapped Variants
General Structure Information 3fzt PTK2B crystal structure of pyk2 complexed with pf-4618433 1.95Å AUTH S.HAN,A.MISTRY,J.S.CHANG,D.CUNNINGHAM,M.GRIFFOR,AUTH 2 P.C.BONNETTE,H.WANG,B.A.CHRUNYK,G.E.ASPNES,AUTH 3 D.P.WALKER,A.D.BROSIUS,L.BUCKBINDERTITL STRUCTURAL CHARACTERIZATION OF PROLINE-RICHTITL 2 TYROSINE KINASE 2 (PYK2) REVEALS A UNIQUE (DFG-OUT)TITL 3 CONFORMATION AND ENABLES INHIBITOR DESIGN.REF J.BIOL.CHEM. V. 284 13193 2009REFN ISSN 0021-9258PMID 19244237DOI 10.1074/JBC.M809038200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3bfn KIF22 crystal structure of the motor domain of human kinesin family member 22 2.3Å AUTH H.ZHU,Y.SHEN,W.TEMPEL,E.DOBROVETSKY,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESINTITL 2 FAMILY MEMBER 22.REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wnt RPS6KA1 crystal structure of the human ribosomal protein s6 kinase 2.4Å AUTH J.R.C.MUNIZ,J.M.ELKINS,J.WANG,E.UGOCHUKWU,E.SALAH,AUTH 2 O.KING,S.PICAUD,F.VON DELFT,C.BOUNTRA,AUTH 3 C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN RIBOSOMAL PROTEINTITL 2 S6 KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3e3r CAPS crystal structure and biochemical characterization of recombinant human calcyphosine delineates a novel ef-hand-containing protein family 2.65Å AUTH H.DONG,X.LI,Z.LOU,X.XU,D.SU,X.ZHOU,W.ZHOU,M.BARTLAM,Z.RAOTITL CRYSTAL-STRUCTURE AND BIOCHEMICAL CHARACTERIZATION OFTITL 2 RECOMBINANT HUMAN CALCYPHOSINE DELINEATES A NOVELTITL 3 EF-HAND-CONTAINING PROTEIN FAMILYREF J.MOL.BIOL. V. 383 455 2008REFN ISSN 0022-2836PMID 18775726DOI 10.1016/J.JMB.2008.08.048 Variant Set Distributions Mapped Variants
General Structure Information 3k05 MDC1 the crystal structure of mdc1 brct t2067d in complex with a minimal recognition tetrapeptide with an amidated c-terminus 1.33Å AUTH S.J.CAMPBELL,R.A.EDWARDS,J.N.GLOVERTITL COMPARISON OF THE STRUCTURES AND PEPTIDE BINDINGTITL 2 SPECIFICITIES OF THE BRCT DOMAINS OF MDC1 AND BRCA1REF STRUCTURE V. 18 167 2010REFN ISSN 0969-2126PMID 20159462DOI 10.1016/J.STR.2009.12.008 Variant Set Distributions […]
General Structure Information 3ii6 XRCC4 structure of human xrcc4 in complex with the tandem brct domains of dna ligaseiv. 2.4Å AUTH P.Y.WU,P.FRIT,S.MEESALA,S.DAUVILLIER,M.MODESTI,AUTH 2 S.N.ANDRES,Y.HUANG,J.SEKIGUCHI,P.CALSOU,B.SALLES,AUTH 3 M.S.JUNOPTITL STRUCTURAL AND FUNCTIONAL INTERACTION BETWEEN THETITL 2 HUMAN DNA REPAIR PROTEINS DNA LIGASE IV AND XRCC4REF MOL.CELL.BIOL. V. 11 3163 2009REFN ISSN 0270-7306PMID 19332554 Variant Set Distributions Mapped Variants
General Structure Information 3ii6 XRCC4 structure of human xrcc4 in complex with the tandem brct domains of dna ligaseiv. 2.4Å AUTH P.Y.WU,P.FRIT,S.MEESALA,S.DAUVILLIER,M.MODESTI,AUTH 2 S.N.ANDRES,Y.HUANG,J.SEKIGUCHI,P.CALSOU,B.SALLES,AUTH 3 M.S.JUNOPTITL STRUCTURAL AND FUNCTIONAL INTERACTION BETWEEN THETITL 2 HUMAN DNA REPAIR PROTEINS DNA LIGASE IV AND XRCC4REF MOL.CELL.BIOL. V. 11 3163 2009REFN ISSN 0270-7306PMID 19332554 Variant Set Distributions Mapped Variants