Assessment of Structural Intolerance and Durability
General Structure Information 3dlm SETDB1 crystal structure of tudor domain of human histone-lysine n- methyltransferase setdb1 1.77Å AUTH L.DOMBROVSKI,M.F.AMAYA,P.LOPPNAU,A.BOCHKAREV,J.MIN,AUTH 2 H.WUTITL THE CRYSTAL STRUCTURE OF TUDOR DOMAIN OF HUMANTITL 2 HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jzx PCBP2 pcbp2 kh1-kh2 domains -1.0Å AUTH Z.DU,S.FENN,R.TJHEN,T.JAMESTITL STRUCTURE OF THE FIRST AND SECOND KH DOMAINS OF HUMAN POLY-CTITL 2 BINDING PROTEIN-2 REVEALS INSIGHTS INTO ITS REGULATORYTITL 3 MECHANISMSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2k1m MYBPC3 3d nmr structure of domain cc0 of cardiac myosin binding protein c (mybpc) -1.0Å AUTH J.RATTI,M.GAUTEL,M.PFUHLTITL 3D NMR STRUCTURE OF DOMAIN CC0 OF CARDIAC MYOSINTITL 2 BINDING PROTEIN C (MYBPC)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vn9 CAMK2D crystal structure of human calcium calmodulin dependent protein kinase ii delta isoform 1, camkd 2.3Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 3fb2 SPTAN1 crystal structure of the human brain alpha spectrin repeats 15 and 16. northeast structural genomics consortium target hr5563a. 2.3Å AUTH S.M.VOROBIEV,M.SU,J.SEETHARAMAN,R.SHASTRY,AUTH 2 E.L.FOOTE,C.CICCOSANTI,H.JANJUA,R.XIAO,T.B.ACTON,AUTH 3 G.T.MONTELIONE,L.TONG,J.F.HUNTTITL CRYSTAL STRUCTURE OF THE HUMAN BRAIN ALPHATITL 2 SPECTRIN REPEATS 15 AND 16.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3sm9 GRM3 crystal structure of metabotropic glutamate receptor 3 precursor in presence of ly341495 antagonist 2.26Å AUTH A.K.WERNIMONT,A.DONG,A.SEITOVA,L.CROMBET,G.KHUTORESKAYA,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,AUTH 3 E.DOBROVETSKYTITL CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR 3TITL 2 PRECURSOR IN PRESENCE OF LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3jue ACAP1 crystal structure of arfgap and ank repeat domain of acap1 2.3Å AUTH M.BAI,X.PANG,J.LOU,Q.ZHOU,K.ZHANG,J.MA,J.LI,F.SUN,V.W.HSUTITL MECHANISTIC INSIGHTS INTO REGULATED CARGO BINDING BY ACAP1TITL 2 PROTEINREF J.BIOL.CHEM. V. 287 28675 2012REFN ISSN 0021-9258PMID 22645133DOI 10.1074/JBC.M112.378810 Variant Set Distributions Mapped Variants
General Structure Information 3iez IQGAP2 crystal structure of the rasgap c-terminal (rgc) domain of iqgap2 1.5Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,N.ZHONG,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RASGAP C-TERMINAL (RGC)TITL 2 DOMAIN OF IQGAP2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kkt ATXN7L3 solution structure of the sca7 domain of human ataxin-7-l3 protein -1.0Å AUTH J.BONNET,Y.WANG,A.ATKINSON,J.KOFFLER,C.ROMIER,A.HAMICHE,AUTH 2 L.TORA,D.DEVYS,B.KIEFFERTITL HISTONE DEUBIQUITINATION BY SAGA IS MODULATED BY ANTITL 2 ATYPICAL ZINC FINGER DOMAIN OF ATAXIN-7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3i4u DHX8 crystal structure analysis of a helicase associated domain 2.1Å AUTH D.KUDLINZKI,A.SCHMITT,H.CHRISTIAN,R.FICNERTITL STRUCTURAL ANALYSIS OF THE C-TERMINAL DOMAIN OF THETITL 2 SPLICEOSOMAL HELICASE PRP22REF BIOL.CHEM. V. 393 1131 2012REFN ISSN 1431-6730PMID 23096351DOI 10.1515/HSZ-2012-0158 Variant Set Distributions Mapped Variants