Assessment of Structural Intolerance and Durability
General Structure Information 3gid ACACB the biotin carboxylase (bc) domain of human acetyl-coa carboxylase 2 (acc2) in complex with soraphen a 2.3Å AUTH B.RAYMER,M.KAVANA,A.PRICE,B.WANG,L.CORCORAN,R.KULATHILA,AUTH 2 J.GROARKE,T.MANNTITL SYNTHESIS AND CHARACTERIZATION OF A BODIPY-LABELEDTITL 2 DERIVATIVE OF SORAPHEN A THAT BINDS TO ACETYL-COATITL 3 CARBOXYLASE.REF BIOORG.MED.CHEM.LETT. V. 19 2804 2009REFN ISSN 0960-894XPMID 19359168DOI 10.1016/J.BMCL.2009.03.107 Variant Set Distributions […]
General Structure Information 3gb8 XPO1 crystal structure of crm1/snurportin-1 complex 2.9Å AUTH X.DONG,A.BISWAS,K.E.SUEL,L.K.JACKSON,R.MARTINEZ,H.GU,AUTH 2 Y.M.CHOOKTITL STRUCTURAL BASIS FOR LEUCINE-RICH NUCLEAR EXPORT SIGNALTITL 2 RECOGNITION BY CRM1.REF NATURE V. 458 1136 2009REFN ISSN 0028-0836PMID 19339969DOI 10.1038/NATURE07975 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3iug ARHGAP32 crystal structure of the rhogap domain of rics 1.77Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,Y.LI,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF RICSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3epp RNMT crystal structure of mrna cap guanine-n7 methyltransferase (rnmt) in complex with sinefungin 2.41Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WUTITL CRYSTAL STRUCTURE OF MRNA CAP GUANINE-N7 METHYLTRANSFERASETITL 2 (RNMT) IN COMPLEX WITH SINEFUNGIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3keu PDXK crystal structure of human pl kinase with bound plp and atp 2.1Å AUTH A.K.GANDHI,F.N.MUSAYEV,M.K.SAFOTITL CRYSTAL STRUCTURE OF PL KINASE IN COMPLEX WITH MGATP ANDTITL 2 PLP: STRUCTURAL BASIS OF SEVERE INDUCED MGATP SUBSTRATETITL 3 INHIBITION OF THE ENZYMEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2krg SLC9A3R1 solution structure of human sodium/ hydrogen exchange regulatory factor 1(150-358) -1.0Å AUTH S.BHATTACHARYA,Z.DAI,J.LI,S.BAXTER,D.J.CALLAWAY,AUTH 2 D.COWBURN,Z.BUTITL A CONFORMATIONAL SWITCH IN THE SODIUM/ HYDROGENTITL 2 EXCHANGE REGULATORY FACTOR 1(NHERF1) CONTROLSTITL 3 AUTOINHIBITION AND COMPLEX FORMATION.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20042604DOI 10.1074/JBC.M109.074005 Variant Set Distributions Mapped Variants
General Structure Information 3ifa FBP2 human muscle fructose-1,6-bisphosphatase e69q mutant in complex with amp 1.93Å AUTH M.ZARZYCKI,R.KOLODZIEJCZYK,E.MACIASZCZYK-DZIUBINSKA,AUTH 2 R.WYSOCKI,M.JASKOLSKI,A.DZUGAJTITL STRUCTURE OF E69Q MUTANT OF HUMAN MUSCLETITL 2 FRUCTOSE-1,6-BISPHOSPHATASEREF ACTA CRYSTALLOGR.,SECT.D V. 67 1028 2011REFN ISSN 0907-4449PMID 22120740DOI 10.1107/S090744491104385X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2k86 FOXO3 solution structure of foxo3a forkhead domain -1.0Å AUTH F.WANG,C.B.MARSHALL,K.YAMAMOTO,G.Y.LI,M.J.PLEVIN,AUTH 2 H.YOU,T.W.MAK,M.IKURATITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF ANTITL 2 INTRAMOLECULAR INTERACTION IN FOXO3A AND ITSTITL 3 BINDING WITH P53.REF J.MOL.BIOL. V. 384 590 2008REFN ISSN 0022-2836PMID 18824006DOI 10.1016/J.JMB.2008.09.025 Variant Set Distributions Mapped Variants
General Structure Information 2zfu RRP8 structure of the methyltransferase-like domain of nucleomethylin 2.0Å AUTH A.MURAYAMA,K.OHMORI,A.FUJIMURA,H.MINAMI,K.YASUZAWA-TANAKA,AUTH 2 T.KURODA,S.OIE,H.DAITOKU,M.OKUWAKI,K.NAGATA,A.FUKAMIZU,AUTH 3 K.KIMURA,T.SHIMIZU,J.YANAGISAWATITL EPIGENETIC CONTROL OF RDNA LOCI IN RESPONSE TO INTRACELLULARTITL 2 ENERGY STATUSREF CELL(CAMBRIDGE,MASS.) V. 133 627 2008REFN ISSN 0092-8674PMID 18485871DOI 10.1016/J.CELL.2008.03.030 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jll NCAM2 crystal structure of ncam2 igiv-fn3ii 2.3Å AUTH N.KULAHIN,O.KRISTENSEN,K.K.RASMUSSEN,L.OLSEN,P.RYDBERG,AUTH 2 B.VESTERGAARD,J.S.KASTRUP,V.BEREZIN,E.BOCK,P.S.WALMOD,AUTH 3 M.GAJHEDETITL STRUCTURAL MODEL AND TRANS-INTERACTION OF THE ENTIRETITL 2 ECTODOMAIN OF THE OLFACTORY CELL ADHESION MOLECULE.REF STRUCTURE V. 19 203 2011REFN ISSN 0969-2126PMID 21300289DOI 10.1016/J.STR.2010.12.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]