4E93.A | FES

General Structure Information 4e93 FES crystal structure of human feline sarcoma viral oncogene homologue (v- fes)in complex with tae684 1.84Å AUTH S.HELLWIG,C.V.MIDUTURU,S.KANDA,J.ZHANG,P.FILIPPAKOPOULOS,AUTH 2 E.SALAH,X.DENG,H.G.CHOI,W.ZHOU,W.HUR,S.KNAPP,N.S.GRAY,AUTH 3 T.E.SMITHGALLTITL SMALL-MOLECULE INHIBITORS OF THE C-FES PROTEIN-TYROSINETITL 2 KINASE.REF CHEM.BIOL. V. 19 529 2012REFN ISSN 1074-5521PMID 22520759DOI 10.1016/J.CHEMBIOL.2012.01.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]

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3LCO.A | CSF1R

General Structure Information 3lco CSF1R inhibitor bound to a dfg-out structure of the kinase domain of csf-1r 3.4Å AUTH M.J.MEYERS,M.PELC,S.KAMTEKAR,J.DAY,G.I.PODA,M.K.HALL,AUTH 2 M.L.MICHENER,B.A.REITZ,K.J.MATHIS,B.S.PIERCE,M.D.PARIKH,AUTH 3 D.A.MISCHKE,S.A.LONG,J.J.PARLOW,D.R.ANDERSON,A.THORARENSENTITL STRUCTURE-BASED DRUG DESIGN ENABLES CONVERSION OF A DFG-INTITL 2 BINDING CSF-1R KINASE INHIBITOR TO A DFG-OUT BINDING MODE.REF BIOORG.MED.CHEM.LETT. V. 20 1543 2010REFN ISSN 0960-894XPMID 20137931DOI 10.1016/J.BMCL.2010.01.078 Variant Set Distributions Pathogenic […]

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3GW3.A | UROD

General Structure Information 3gw3 UROD human urod mutant k297n 1.7Å AUTH C.A.WARBY,J.D.PHILLIPS,H.A.BERGONIA,F.G.WHITBY,C.P.HILL,AUTH 2 J.P.KUSHNERTITL STRUCTURAL AND KINETIC CHARACTERIZATION OF MUTANT HUMANTITL 2 UROPORPHYRINOGEN DECARBOXYLASES.REF CELL MOL BIOL V. 55 40 2009REF 2 (NOISY-LE-GRAND)REFNPMID 19656450 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants

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3KBT.B | SPTB

General Structure Information 3kbt SPTB crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (zu5-ank) 2.75Å AUTH J.J.IPSARO,A.MONDRAGONTITL STRUCTURAL BASIS FOR SPECTRIN RECOGNITION BY ANKYRIN.REF BLOOD V. 115 4093 2010REFN ISSN 0006-4971PMID 20101027DOI 10.1182/BLOOD-2009-11-255604 Variant Set Distributions Ripley’s K […]

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3FFN.B | GSN

General Structure Information 3ffn GSN crystal structure of calcium-free human gelsolin 3.0Å AUTH S.NAG,Q.MA,H.WANG,S.CHUMNARNSILPA,W.L.LEE,AUTH 2 M.LARSSON,B.KANNAN,M.HERNANDEZ-VALLADARES,AUTH 3 L.D.BURTNICK,R.C.ROBINSONTITL CA2+ BINDING BY DOMAIN 2 PLAYS A CRITICAL ROLE INTITL 2 THE ACTIVATION AND STABILIZATION OF GELSOLIN.REF PROC.NATL.ACAD.SCI.USA V. 106 13713 2009REFN ISSN 0027-8424PMID 19666512DOI 10.1073/PNAS.0812374106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]

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2ROL.B | CD3E

General Structure Information 2rol CD3E structural basis of pxxdy motif recognition in sh3 binding -1.0Å AUTH O.AITIO,M.HELLMAN,T.KESTI,I.KLEINO,O.SAMUILOVA,AUTH 2 K.PAAKKONEN,H.TOSSAVAINEN,K.SAKSELA,P.PERMITITL STRUCTURAL BASIS OF PXXDY MOTIF RECOGNITION IN SH3TITL 2 BINDINGREF J.MOL.BIOL. V. 382 167 2008REFN ISSN 0022-2836PMID 18644376DOI 10.1016/J.JMB.2008.07.008 Variant Set Distributions Mapped Variants

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3FCS.C | ITGA2B

General Structure Information 3fcs ITGA2B structure of complete ectodomain of integrin aiibb3 2.55Å AUTH J.ZHU,B.H.LUO,T.XIAO,C.ZHANG,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF A COMPLETE INTEGRIN ECTODOMAIN IN A PHYSIOLOGICTITL 2 RESTING STATE AND ACTIVATION AND DEACTIVATION BY APPLIEDTITL 3 FORCES.REF MOL.CELL V. 32 849 2008REFN ISSN 1097-2765PMID 19111664DOI 10.1016/J.MOLCEL.2008.11.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]

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3LDL.B | HSPA5

General Structure Information 3ldl HSPA5 crystal structure of human grp78 (70kda heat shock protein 5 / bip) atpase domain in complex with atp 2.3Å AUTH A.T.MACIAS,D.S.WILLIAMSON,N.ALLEN,J.BORGOGNONI,A.CLAY,AUTH 2 Z.DANIELS,P.DOKURNO,M.J.DRYSDALE,G.L.FRANCIS,C.J.GRAHAM,AUTH 3 R.HOWES,N.MATASSOVA,J.B.MURRAY,R.PARSONS,T.SHAW,AUTH 4 A.E.SURGENOR,L.TERRY,Y.WANG,M.WOOD,A.J.MASSEYTITL ADENOSINE-DERIVED INHIBITORS OF 78 KDA GLUCOSE REGULATEDTITL 2 PROTEIN (GRP78) ATPASE: INSIGHTS INTO ISOFORM SELECTIVITY.REF J.MED.CHEM. V. 54 4034 2011REFN ISSN 0022-2623PMID 21526763DOI […]

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3IE3.A | GSTP1

General Structure Information 3ie3 GSTP1 structural basis for the binding of the anti-cancer compound 6-(7- nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (nbdhex) to human glutathione s-transferases 1.8Å AUTH L.FEDERICI,C.LO STERZO,S.PEZZOLA,A.DI MATTEO,F.SCALONI,AUTH 2 G.FEDERICI,A.M.CACCURITITL STRUCTURAL BASIS FOR THE BINDING OF THE ANTICANCER COMPOUNDTITL 2 6-(7-NITRO-2,1,3-BENZOXADIAZOL-4-YLTHIO)HEXANOL TO HUMANTITL 3 GLUTATHIONE S-TRANSFERASESREF CANCER RES. V. 69 8025 2009REFN ISSN 0008-5472PMID 19808963DOI 10.1158/0008-5472.CAN-09-1314 Variant […]

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3G0F.B | KIT

General Structure Information 3g0f KIT kit kinase domain mutant d816h in complex with sunitinib 2.6Å AUTH K.S.GAJIWALA,J.C.WU,J.CHRISTENSEN,G.D.DESHMUKH,AUTH 2 W.DIEHL,J.P.DINITTO,J.M.ENGLISH,M.J.GREIG,Y.A.HE,AUTH 3 S.L.JACQUES,E.A.LUNNEY,M.MCTIGUE,D.MOLINA,AUTH 4 T.QUENZER,P.A.WELLS,X.YU,Y.ZHANG,A.ZOU,M.R.EMMETT,AUTH 5 A.G.MARSHALL,H.M.ZHANG,G.D.DEMETRITITL KIT KINASE MUTANTS SHOW UNIQUE MECHANISMS OF DRUGTITL 2 RESISTANCE TO IMATINIB AND SUNITINIB INTITL 3 GASTROINTESTINAL STROMAL TUMOR PATIENTS.REF PROC.NATL.ACAD.SCI.USA V. 106 1542 2009REFN ISSN 0027-8424PMID 19164557DOI 10.1073/PNAS.0812413106 Variant […]

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