Assessment of Structural Intolerance and Durability
General Structure Information 3cnk FLNA crystal structure of the dimerization domain of human filamin a 1.65Å AUTH M.-D.SEO,S.-H.SEOK,H.IM,A.-R.KWON,S.-J.LEE,AUTH 2 H.-R.KIM,Y.CHO,D.PARK,B.-J.LEETITL CRYSTAL STRUCTURE OF THE DIMERIZATION DOMAIN OFTITL 2 HUMAN FILAMIN AREF PROTEINS V. 75 258 2008REFN ISSN 0887-3585PMID 19137608DOI 10.1002/PROT.22336 Variant Set Distributions Mapped Variants
General Structure Information 2k4t VDAC1 solution structure of human vdac-1 in ldao micelles -1.0Å AUTH S.HILLER,R.G.GARCES,T.J.MALIA,V.Y.OREKHOV,AUTH 2 M.COLOMBINI,G.WAGNERTITL SOLUTION STRUCTURE OF THE INTEGRAL HUMAN MEMBRANETITL 2 PROTEIN VDAC-1 IN DETERGENT MICELLES.REF SCIENCE V. 321 1206 2008REFN ISSN 0036-8075PMID 18755977DOI 10.1126/SCIENCE.1161302 Variant Set Distributions Mapped Variants
General Structure Information 2jjd PTPRE protein tyrosine phosphatase, receptor type, e isoform 3.2Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2k3t FLNA solution structure of ig-like domain 23 from human filamin a -1.0Å AUTH F.NAKAMURA,O.HEIKKINEN,O.T.PENTIKAINEN,T.M.OSBORN,AUTH 2 K.E.KASZA,D.A.WEITZ,O.KUPIAINEN,P.PERMI,AUTH 3 I.KILPELAINEN,J.YLANNE,J.H.HARTWIG,T.P.STOSSELTITL MOLECULAR BASIS OF FILAMIN A-FILGAP INTERACTIONTITL 2 AND ITS IMPAIRMENT IN CONGENITAL DISORDERSTITL 3 ASSOCIATED WITH FILAMIN A MUTATIONSREF PLOS ONE V. 4 E4928 2009REFN ESSN 1932-6203PMID 19293932DOI 10.1371/JOURNAL.PONE.0004928 Variant Set Distributions Mapped […]
General Structure Information 2k1l EPHA1 nmr structures of dimeric transmembrane domain of the receptor tyrosine kinase epha1 in lipid bicelles at ph 6.3 -1.0Å AUTH E.V.BOCHAROV,M.L.MAYZEL,P.E.VOLYNSKY,M.V.GONCHARUK,AUTH 2 Y.S.ERMOLYUK,A.A.SCHULGA,E.O.ARTEMENKO,R.G.EFREMOV,AUTH 3 A.S.ARSENIEVTITL SPATIAL STRUCTURE AND PH-DEPENDENT CONFORMATIONALTITL 2 DIVERSITY OF DIMERIC TRANSMEMBRANE DOMAIN OF THETITL 3 RECEPTOR TYROSINE KINASE EPHA1.REF J.BIOL.CHEM. V. 283 29385 2008REFN ISSN 0021-9258PMID […]
General Structure Information 3bpo IL4R crystal structure of the il13-il4r-il13ra ternary complex 3.0Å AUTH S.L.LAPORTE,Z.S.JUO,J.VACLAVIKOVA,L.A.COLF,X.QI,N.M.HELLER,AUTH 2 A.D.KEEGAN,K.C.GARCIATITL MOLECULAR AND STRUCTURAL BASIS OF CYTOKINE RECEPTORTITL 2 PLEIOTROPY IN THE INTERLEUKIN-4/13 SYSTEM.REF CELL(CAMBRIDGE,MASS.) V. 132 259 2008REFN ISSN 0092-8674PMID 18243101DOI 10.1016/J.CELL.2007.12.030 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f1p ARNT crystal structure of a high affinity heterodimer of hif2 alpha and arnt c-terminal pas domains 1.17Å AUTH T.H.SCHEUERMANN,D.R.TOMCHICK,M.MACHIUS,Y.GUO,AUTH 2 R.K.BRUICK,K.H.GARDNERTITL ARTIFICIAL LIGAND BINDING WITHIN THE HIF2ALPHATITL 2 PAS-B DOMAIN OF THE HIF2 TRANSCRIPTION FACTOR.REF PROC.NATL.ACAD.SCI.USA V. 106 450 2009REFN ISSN 0027-8424PMID 19129502DOI 10.1073/PNAS.0808092106 Variant Set Distributions Mapped Variants
General Structure Information 2wfn FLNA filamin a actin binding domain 3.2Å AUTH S.RUSKAMO,J.YLANNETITL STRUCTURE OF THE HUMAN FILAMIN A ACTIN-BINDING DOMAINREF ACTA CRYSTALLOGR.,SECT.D V. 65 1217 2009REFN ISSN 0907-4449PMID 19923718DOI 10.1107/S0907444909037330 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2w99 CCND1 crystal structure of cdk4 in complex with a d-type cyclin 2.8Å AUTH P.J.DAY,A.CLEASBY,I.J.TICKLE,M.OREILLY,J.E.COYLE,AUTH 2 F.P.HOLDING,R.L.MCMENAMIN,J.YON,R.CHOPRA,AUTH 3 C.LENGAUER,H.JHOTITITL CRYSTAL STRUCTURE OF HUMAN CDK4 IN COMPLEX WITH ATITL 2 D-TYPE CYCLIN.REF PROC.NATL.ACAD.SCI.USA V. 106 4166 2009REFN ISSN 0027-8424PMID 19237565DOI 10.1073/PNAS.0809645106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3kul EPHA8 kinase domain of human ephrin type-a receptor 8 (epha8) 2.15Å AUTH J.R.WALKER,L.YERMEKBAYEVA,J.KANIA,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 8 (EPHA8)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants