Assessment of Structural Intolerance and Durability
General Structure Information 3bvo HSCB crystal structure of human co-chaperone protein hscb 3.0Å AUTH E.BITTO,C.A.BINGMAN,L.BITTOVA,D.A.KONDRASHOV,R.M.BANNEN,AUTH 2 B.G.FOX,J.L.MARKLEY,G.N.PHILLIPSTITL STRUCTURE OF HUMAN J-TYPE CO-CHAPERONE HSCB REVEALS ATITL 2 TETRACYSTEINE METAL-BINDING DOMAIN.REF J.BIOL.CHEM. V. 283 30184 2008REFN ISSN 0021-9258PMID 18713742DOI 10.1074/JBC.M804746200 Variant Set Distributions Mapped Variants
General Structure Information 3bpt HIBCH crystal structure of human beta-hydroxyisobutyryl-coa hydrolase in complex with quercetin 1.5Å AUTH E.S.PILKA,C.PHILLIPS,O.N.F.KING,K.GUO,F.VON DELFT,AUTH 2 A.C.W.PIKE,C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA-HYDROXYISOBUTYRYL-COATITL 2 HYDROLASE IN COMPLEX WITH QUERCETIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l5u CHD4 structure of the first phd finger (phd1) from chd4 (mi2b) -1.0Å AUTH R.E.MANSFIELD,C.A.MUSSELMAN,A.H.KWAN,S.S.OLIVER,A.L.GARSKE,AUTH 2 F.DAVRAZOU,J.M.DENU,T.G.KUTATELADZE,J.P.MACKAYTITL PLANT HOMEODOMAIN (PHD) FINGERS OF CHD4 ARE HISTONETITL 2 H3-BINDING MODULES WITH PREFERENCE FOR UNMODIFIED H3K4 ANDTITL 3 METHYLATED H3K9REF J.BIOL.CHEM. V. 286 11779 2011REFN ISSN 0021-9258PMID 21278251DOI 10.1074/JBC.M110.208207 Variant Set Distributions Mapped Variants
General Structure Information 3bua TERF2 crystal structure of trf2 trfh domain and apollo peptide complex 2.5Å AUTH Y.CHEN,Y.YANG,M.VAN OVERBEEK,J.R.DONIGIAN,P.BACIU,AUTH 2 T.DE LANGE,M.LEITITL A SHARED DOCKING MOTIF IN TRF1 AND TRF2 USED FORTITL 2 DIFFERENTIAL RECRUITMENT OF TELOMERIC PROTEINS.REF SCIENCE V. 319 1092 2008REFN ISSN 0036-8075PMID 18202258DOI 10.1126/SCIENCE.1151804 Variant Set Distributions Mapped Variants
General Structure Information 2vze ACSM2A crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in complex with amp 2.45Å AUTH G.KOCHAN,E.S.PILKA,F.V.DELFT,U.OPPERMANN,W.W.YUETITL STRUCTURAL SNAPSHOTS FOR THE CONFORMATION- DEPENDENTTITL 2 CATALYSIS BY HUMAN MEDIUM-CHAIN ACYL- COENZYME A SYNTHETASETITL 3 ACSM2A.REF J.MOL.BIOL. V. 388 997 2009REFN ISSN 0022-2836PMID 19345228DOI 10.1016/J.JMB.2009.03.064 Variant Set Distributions Ripley’s K […]
General Structure Information 3w9y DLG1 crystal structure of the human dlg1 guanylate kinase domain 2.2Å AUTH S.MORI,Y.TEZUKA,A.ARAKAWA,N.HANDA,M.SHIROUZU,T.AKIYAMA,AUTH 2 S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE GUANYLATE KINASE DOMAIN FROM DISCSTITL 2 LARGE HOMOLOG 1 (DLG1/SAP97)REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 435 334 2013REFN ISSN 0006-291XPMID 23624197DOI 10.1016/J.BBRC.2013.04.056 Variant Set Distributions Mapped Variants
General Structure Information 1aqc APBA1 x11 ptb domain-10mer peptide complex 2.3Å AUTH Z.ZHANG,C.H.LEE,V.MANDIYAN,J.P.BORG,B.MARGOLIS,AUTH 2 J.SCHLESSINGER,J.KURIYANTITL SEQUENCE-SPECIFIC RECOGNITION OF THETITL 2 INTERNALIZATION MOTIF OF THE ALZHEIMERS AMYLOIDTITL 3 PRECURSOR PROTEIN BY THE X11 PTB DOMAIN.REF EMBO J. V. 16 6141 1997REFN ISSN 0261-4189PMID 9321393DOI 10.1093/EMBOJ/16.20.6141 Variant Set Distributions Mapped Variants
General Structure Information 3cyy TJP1 the crystal structure of zo-1 pdz2 in complex with the cx43 peptide 2.4Å AUTH J.CHEN,L.PAN,Z.WEI,Y.ZHAO,M.ZHANGTITL DOMAIN-SWAPPED DIMERIZATION OF ZO-1 PDZ2 GENERATES SPECIFICTITL 2 AND REGULATORY CONNEXIN43-BINDING SITESREF EMBO J. V. 27 2113 2008REFN ISSN 0261-4189PMID 18636092DOI 10.1038/EMBOJ.2008.138 Variant Set Distributions Mapped Variants
General Structure Information 3ull SSBP1 human mitochondrial single-stranded dna binding protein 2.4Å AUTH C.YANG,U.CURTH,C.URBANKE,C.KANGTITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIALTITL 2 SINGLE-STRANDED DNA BINDING PROTEIN AT 2.4 ATITL 3 RESOLUTION.REF NAT.STRUCT.BIOL. V. 4 153 1997REFN ISSN 1072-8368PMID 9033597DOI 10.1038/NSB0297-153 Variant Set Distributions Mapped Variants
General Structure Information 2ymk DCD crystal structure of the hexameric anti-microbial peptide channel dermcidin 2.49Å AUTH C.SONG,C.WEICHBRODT,E.S.SALNIKOV,M.DYNOWSKI,B.O.FORSBERG,AUTH 2 B.BECHINGER,C.STEINEM,B.L.DE GROOT,U.ZACHARIAE,K.ZETHTITL CRYSTAL STRUCTURE AND FUNCTIONAL MECHANISM OF A HUMANTITL 2 ANTIMICROBIAL MEMBRANE CHANNEL.REF PROC.NATL.ACAD.SCI.USA V. 110 4586 2013REFN ISSN 0027-8424PMID 23426625DOI 10.1073/PNAS.1214739110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]