Assessment of Structural Intolerance and Durability
General Structure Information 2vpd PYGO1 decoding of methylated histone h3 tail by the pygo-bcl9 wnt signaling complex 2.77Å AUTH M.FIEDLER,M.J.SANCHEZ-BARRENA,M.NEKRASOV,AUTH 2 J.MIESZCZANEK,V.RYBIN,J.MULLER,P.EVANS,M.BIENZTITL DECODING OF METHYLATED HISTONE H3 TAIL BY THETITL 2 PYGO- BCL9 WNT SIGNALING COMPLEX.REF MOL.CELL V. 30 507 2008REFN ISSN 1097-2765PMID 18498752DOI 10.1016/J.MOLCEL.2008.03.011 Variant Set Distributions Mapped Variants
General Structure Information 3ebb PLAA plap/p97 complex 1.9Å AUTH L.QIU,N.PASHKOVA,J.R.WALKER,S.WINISTORFER,A.ALLALI-HASSANI,AUTH 2 M.AKUTSU,R.PIPER,S.DHE-PAGANONTITL STRUCTURE AND FUNCTION OF THE PLAA/UFD3-P97/CDC48 COMPLEX.REF J.BIOL.CHEM. V. 285 365 2010REFN ISSN 0021-9258PMID 19887378DOI 10.1074/JBC.M109.044685 Variant Set Distributions Mapped Variants
General Structure Information 2ygq WIF1 wif domain-epidermal growth factor (egf)-like domains 1-3 of human wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine 3.95Å AUTH T.MALINAUSKAS,A.R.ARICESCU,W.LU,C.SIEBOLD,E.Y.JONESTITL MODULAR MECHANISM OF WNT SIGNALING INHIBITION BY WNTTITL 2 INHIBITORY FACTOR 1REF NAT.STRUCT.MOL.BIOL. V. 18 886 2011REFN ISSN 1545-9993PMID 21743455DOI 10.1038/NSMB.2081 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3hcs TRAF6 crystal structure of the n-terminal domain of traf6 2.2Å AUTH Q.YIN,S.C.LIN,B.LAMOTHE,M.LU,Y.C.LO,G.HURA,L.ZHENG,AUTH 2 R.L.RICH,A.D.CAMPOS,D.G.MYSZKA,M.J.LENARDO,AUTH 3 B.G.DARNAY,H.WUTITL E2 INTERACTION AND DIMERIZATION IN THE CRYSTALTITL 2 STRUCTURE OF TRAF6.REF NAT.STRUCT.MOL.BIOL. V. 16 658 2009REFN ISSN 1545-9993PMID 19465916DOI 10.1038/NSMB.1605 Variant Set Distributions Mapped Variants
General Structure Information 3ihr UCHL5 crystal structure of uch37 2.95Å AUTH S.E.BURGIE,C.A.BINGMAN,A.B.SONI,G.N.PHILLIPSTITL STRUCTURAL CHARACTERIZATION OF HUMAN UCH37.REF PROTEINS 2011REFN ESSN 1097-0134PMID 21953935DOI 10.1002/PROT.23147 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2izs CSNK1G3 structure of casein kinase gamma 3 in complex with inhibitor 1.95Å AUTH G.BUNKOCZI,E.SALAH,P.RELLOS,S.DAS,O.FEDOROV,P.SAVITSKY,AUTH 2 J.E.DEBRECZENI,O.GILEADI,M.SUNDSTROM,A.EDWARDS,C.ARROWSMITH,AUTH 3 J.WEIGELT,F.VON DELFT,S.KNAPPTITL INHIBITOR BINDING BY CASEIN KINASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ice VSIG4 crig bound to c3c 3.1Å AUTH C.WIESMANN,K.J.KATSCHKE,J.YIN,K.Y.HELMY,M.STEFFEK,AUTH 2 W.J.FAIRBROTHER,S.A.MCCALLUM,L.EMBUSCADO,L.DEFORGE,P.E.HASS,AUTH 3 M.VAN LOOKEREN CAMPAGNETITL STRUCTURE OF C3B IN COMPLEX WITH CRIG GIVES INSIGHTS INTOTITL 2 REGULATION OF COMPLEMENT ACTIVATION.REF NATURE V. 444 217 2006REFN ISSN 0028-0836PMID 17051150DOI 10.1038/NATURE05263 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3evx UFC1 crystal structure of the human e2-like ubiquitin-fold modifier conjugating enzyme 1 (ufc1). northeast structural genomics consortium target hr41 2.54Å AUTH G.LIU,F.FOROUHAR,A.ELETSKY,H.S.ATREYA,J.M.ARAMINI,AUTH 2 R.XIAO,Y.J.HUANG,M.ABASHIDZE,J.SEETHARAMAN,J.LIU,AUTH 3 B.ROST,T.ACTON,G.T.MONTELIONE,J.F.HUNT,T.SZYPERSKITITL NMR AND X-RAY STRUCTURES OF HUMAN E2-LIKETITL 2 UBIQUITIN-FOLD MODIFIER CONJUGATING ENZYME 1TITL 3 (UFC1) REVEAL STRUCTURAL AND FUNCTIONALTITL 4 CONSERVATION IN THE METAZOAN UFM1-UBA5-UFC1TITL […]
General Structure Information 3k0w MALT1 crystal structure of the tandem ig-like c2-type 2 domains of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1 2.8Å AUTH J.R.WALKER,L.QIU,C.BUTLER-COLE,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL STRUCTURE OF THE TANDEM IG-LIKE C2-TYPE 2 DOMAINSTITL 2 OF THE HUMAN MUCOSA-ASSOCIATED LYMPHOID TISSUETITL 3 LYMPHOMA TRANSLOCATION PROTEIN 1.REF TO BE PUBLISHEDREFN Variant […]
General Structure Information 4ch9 KLHL3 crystal structure of the human klhl3 kelch domain in complex with a wnk4 peptide 1.84Å AUTH F.SCHUMACHER,F.J.SORRELL,D.R.ALESSI,A.N.BULLOCK,T.KURZTITL STRUCTURAL AND BIOCHEMICAL CHARACTERISATION OF THE KLHL3-TITL 2 WNK KINASE INTERACTION IMPORTANT IN BLOOD PRESSURETITL 3 REGULATION.REF BIOCHEM.J. V. 460 237 2014REFN ISSN 0264-6021PMID 24641320DOI 10.1042/BJ20140153 Variant Set Distributions Mapped Variants