Assessment of Structural Intolerance and Durability
General Structure Information 2z7x TLR2 crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide 2.1Å AUTH M.S.JIN,S.E.KIM,J.Y.HEO,M.E.LEE,H.M.KIM,S.G.PAIK,H.LEE,AUTH 2 J.O.LEETITL CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BYTITL 2 BINDING OF A TRI-ACYLATED LIPOPEPTIDEREF CELL(CAMBRIDGE,MASS.) V. 130 1071 2007REFN ISSN 0092-8674PMID 17889651DOI 10.1016/J.CELL.2007.09.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2v9s SLIT2 second lrr domain of human slit2 2.0Å AUTH C.MORLOT,N.M.THIELENS,R.B.RAVELLI,W.HEMRIKA,R.A.ROMIJN,AUTH 2 P.GROS,S.CUSACK,A.A.MCCARTHYTITL STRUCTURAL INSIGHTS INTO THE SLIT-ROBO COMPLEX.REF PROC.NAT.ACAD.SCI.USA V. 104 14923 2007REFN ISSN 0027-8424PMID 17848514DOI 10.1073/PNAS.0705310104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3g65 HUS1 crystal structure of the human rad9-rad1-hus1 dna damage checkpoint complex 2.9Å AUTH A.S.DORE,M.L.KILKENNY,N.J.RZECHORZEK,L.H.PEARLTITL CRYSTAL STRUCTURE OF THE RAD9-RAD1-HUS1 DNA DAMAGETITL 2 CHECKPOINT COMPLEX–IMPLICATIONS FOR CLAMP LOADING ANDTITL 3 REGULATION.REF MOL.CELL V. 34 735 2009REFN ISSN 1097-2765PMID 19446481DOI 10.1016/J.MOLCEL.2009.04.027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4n68 CNTN5 crystal structure of an internal fn3 domain from human contactin-5 [psi-nysgrc-005804] 1.8Å AUTH P.R.KUMAR,A.CASADEVALL,S.C.ALMOTITL CRYSTAL STRUCTURE OF AN INTERNAL FN3 DOMAIN FROM HUMANTITL 2 CONTACTIN-5 [PSI-NYSGRC-005804]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4cai DYSF structure of inner dysf domain of human dysferlin 2.2Å AUTH A.SULA,A.R.COLE,C.YEATS,C.ORENGO,N.H.KEEPTITL CRYSTAL STRUCTURES OF THE HUMAN DYSFERLIN INNER DYSF DOMAINREF BMC STRUCT.BIOL. V. 14 3 2014REFN ISSN 1472-6807PMID 24438169DOI 10.1186/1472-6807-14-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4i1h PARK2 structure of parkin e3 ligase 2.0Å AUTH B.E.RILEY,J.C.LOUGHEED,K.CALLAWAY,M.VELASQUEZ,E.BRECHT,AUTH 2 L.NGUYEN,T.SHALER,D.WALKER,Y.YANG,K.REGNSTROM,L.DIEP,AUTH 3 Z.ZHANG,S.CHIOU,M.BOVA,D.R.ARTIS,N.YAO,J.BAKER,T.YEDNOCK,AUTH 4 J.A.JOHNSTONTITL STRUCTURE AND FUNCTION OF PARKIN E3 UBIQUITIN LIGASE REVEALSTITL 2 ASPECTS OF RING AND HECT LIGASES.REF NAT COMMUN V. 4 1982 2013REFN ESSN 2041-1723PMID 23770887DOI 10.1038/NCOMMS2982 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4l9m RASGRP1 autoinhibited state of the ras-specific exchange factor rasgrp1 3.0Å AUTH J.S.IWIG,Y.VERCOULEN,R.DAS,T.BARROS,A.LIMNANDER,Y.CHE,AUTH 2 J.G.PELTON,D.E.WEMMER,J.P.ROOSE,J.KURIYANTITL STRUCTURAL ANALYSIS OF AUTOINHIBITION IN THE RAS-SPECIFICTITL 2 EXCHANGE FACTOR RASGRP1.REF ELIFE V. 2 00813 2013REFN ESSN 2050-084XPMID 23908768DOI 10.7554/ELIFE.00813 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1x2q STAM2 solution structure of the sh3 domain of the signal transducing adaptor molecule 2 -1.0Å AUTH E.CHIKAYAMA,T.KIGAWA,M.SATO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THE SIGNALTITL 2 TRANSDUCING ADAPTOR MOLECULE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kfq CTSV unreduced cathepsin v in complex with stefin a 1.99Å AUTH M.RENKO,D.TURKTITL UNREDUCED CATHEPSIN V IN COMPLEX WITH STEFIN AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bc5 XYLB crystal structure of human d-xylulokinase in complex with inhibitor 5-deoxy-5-fluoro-d-xylulose 1.98Å AUTH R.D.BUNKER,E.M.M.BULLOCH,J.M.J.DICKSON,K.M.LOOMES,E.N.BAKERTITL STRUCTURE AND FUNCTION OF HUMAN XYLULOKINASE, AN ENZYMETITL 2 WITH IMPORTANT ROLES IN CARBOHYDRATE METABOLISMREF J.BIOL.CHEM. V. 288 1643 2013REFN ISSN 0021-9258PMID 23179721DOI 10.1074/JBC.M112.427997 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]