Assessment of Structural Intolerance and Durability
General Structure Information 1h8b ACTN2 ef-hands 3,4 from alpha-actinin / z-repeat 7 from titin -1.0Å AUTH R.A.ATKINSON,C.JOSEPH,G.KELLY,F.W.MUSKETT,AUTH 2 T.A.FRENKIEL,D.NIETLISPACH,A.PASTORETITL CA2+-INDEPENDENT BINDING OF AN EF-HAND DOMAIN TO ATITL 2 NOVEL MOTIF IN THE ALPHA-ACTININ-TITIN COMPLEXREF NAT.STRUCT.BIOL. V. 8 853 2001REFN ISSN 1072-8368PMID 11573089DOI 10.1038/NSB1001-853 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3fmp NUP214 crystal structure of the nucleoporin nup214 in complex with the dead- box helicase ddx19 3.19Å AUTH J.NAPETSCHNIG,S.A.KASSUBE,E.W.DEBLER,R.W.WONG,G.BLOBEL,AUTH 2 A.HOELZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE INTERACTIONTITL 2 BETWEEN THE NUCLEOPORIN NUP214 AND THE DEAD-BOX HELICASETITL 3 DDX19.REF PROC.NATL.ACAD.SCI.USA V. 106 3089 2009REFN ISSN 0027-8424PMID 19208808DOI 10.1073/PNAS.0813267106 Variant Set Distributions Ripley’s […]
General Structure Information 2dm0 TXK solution structure of the sh2 domain of human tyrosine- protein kinase txk -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH2 DOMAIN OF HUMANTITL 2 TYROSINE-PROTEIN KINASE TXKREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qs9 FLT3 crystal structure of a human flt3 ligand-receptor ternary complex 7.8Å AUTH K.VERSTRAETE,G.VANDRIESSCHE,M.JANUAR,J.ELEGHEERT,AUTH 2 A.V.SHKUMATOV,A.DESFOSSES,K.VAN CRAENENBROECK,D.I.SVERGUN,AUTH 3 I.GUTSCHE,B.VERGAUWEN,S.N.SAVVIDESTITL STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR ASSEMBLY OF THETITL 2 HEMATOPOIETIC FLT3 SIGNALING COMPLEX.REF BLOOD V. 118 60 2011REFN ISSN 0006-4971PMID 21389326DOI 10.1182/BLOOD-2011-01-329532 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2psr S100A7 human psoriasin (s100a7) ca2+ and zn2+ bound form (crystal form ii) 2.05Å AUTH D.E.BRODERSEN,J.NYBORG,M.KJELDGAARDTITL ZINC-BINDING SITE OF AN S100 PROTEIN REVEALED. TWO CRYSTALTITL 2 STRUCTURES OF CA2+-BOUND HUMAN PSORIASIN (S100A7) IN THETITL 3 ZN2+-LOADED AND ZN2+-FREE STATES.REF BIOCHEMISTRY V. 38 1695 1999REFN ISSN 0006-2960PMID 10026247DOI 10.1021/BI982483D Variant Set Distributions Ripley’s […]
General Structure Information 2v40 ADSS human adenylosuccinate synthetase isozyme 2 in complex with gdp 1.9Å AUTH M.WELIN,M.MOCHE,C.ARROWSMITH,H.BERGLUND,R.BUSAM,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,B.M.HALLBERG,AUTH 4 L.HOLMBERG-SCHIAVONE,I.JOHANSSON,A.KALLAS,AUTH 5 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,T.NYMAN,D.OGG,AUTH 6 C.PERSSON,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 7 A.G.THORSELL,S.VAN-DEN-BERG,J.WEIGELT,P.NORDLUNDTITL HUMAN ADENYLOSUCCINATE SYNTHETASE ISOZYME 2 INTITL 2 COMPLEX WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1f5n GBP1 human guanylate binding protein-1 in complex with the gtp analogue, gmppnp. 1.7Å AUTH B.PRAKASH,L.RENAULT,G.J.PRAEFCKE,C.HERRMANN,AUTH 2 A.WITTINGHOFERTITL TRIPHOSPHATE STRUCTURE OF GUANYLATE-BINDINGTITL 2 PROTEIN 1 AND IMPLICATIONS FOR NUCLEOTIDE BINDINGTITL 3 AND GTPASE MECHANISM.REF EMBO J. V. 19 4555 2000REFN ISSN 0261-4189PMID 10970849DOI 10.1093/EMBOJ/19.17.4555 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3npc MAPK9 crystal structure of jnk2 complexed with birb796 2.35Å AUTH A.KUGLSTATTER,M.GHATE,S.TSING,A.G.VILLASENOR,D.SHAW,AUTH 2 J.W.BARNETT,M.F.BROWNERTITL X-RAY CRYSTAL STRUCTURE OF JNK2 COMPLEXED WITH THE P38ALPHATITL 2 INHIBITOR BIRB796: INSIGHTS INTO THE RATIONAL DESIGN OFTITL 3 DFG-OUT BINDING MAP KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 20 5217 2010REFN ISSN 0960-894XPMID 20655210DOI 10.1016/J.BMCL.2010.06.157 Variant Set Distributions Ripley’s K […]
General Structure Information 3l5w IL13 crystal structure of the complex between il-13 and c836 fab 2.0Å AUTH J.FRANSSON,A.TEPLYAKOV,G.RAGHUNATHAN,E.CHI,W.CORDIER,AUTH 2 T.DINH,Y.FENG,J.GILES-KOMAR,G.GILLILAND,B.LOLLO,T.J.MALIA,AUTH 3 W.NISHIOKA,G.OBMOLOVA,S.ZHAO,Y.ZHAO,R.V.SWANSON,J.C.ALMAGROTITL HUMAN FRAMEWORK ADAPTATION OF A MOUSE ANTI-HUMAN IL-13TITL 2 ANTIBODY.REF J.MOL.BIOL. V. 398 214 2010REFN ISSN 0022-2836PMID 20226193DOI 10.1016/J.JMB.2010.03.004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2fcb FCGR2B human fc gamma receptor iib ectodomain (cd32) 1.74Å AUTH P.SONDERMANN,R.HUBER,U.JACOBTITL CRYSTAL STRUCTURE OF THE SOLUBLE FORM OF THE HUMANTITL 2 FCGAMMA-RECEPTOR IIB: A NEW MEMBER OF THETITL 3 IMMUNOGLOBULIN SUPERFAMILY AT 1.7 A RESOLUTION.REF EMBO J. V. 18 1095 1999REFN ISSN 0261-4189PMID 10064577DOI 10.1093/EMBOJ/18.5.1095 Variant Set Distributions Ripley’s K Analysis […]