Assessment of Structural Intolerance and Durability
General Structure Information 1qk9 MECP2 the solution structure of the domain from mecp2 that binds to methylated dna -1.0Å AUTH R.I.D.WAKEFIELD,B.O.SMITH,X.NAN,A.FREE,A.SOTERIOU,AUTH 2 D.UHRIN,A.P.BIRD,P.N.BARLOWTITL THE SOLUTION STRUCTURE OF THE DOMAIN FROM MECP2TITL 2 THAT BINDS TO METHYLATED DNAREF J.MOL.BIOL. V. 291 1055 1999REFN ISSN 0022-2836 70PMID 10518942DOI 10.1006/JMBI.1999.3023 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3nbn NOTCH1 crystal structure of a dimer of notch transcription complex trimers on hes1 dna 3.45Å AUTH K.L.ARNETT,M.HASS,D.G.MCARTHUR,M.X.ILAGAN,J.C.ASTER,R.KOPAN,AUTH 2 S.C.BLACKLOWTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO COOPERATIVETITL 2 ASSEMBLY OF DIMERIC NOTCH TRANSCRIPTION COMPLEXES.REF NAT.STRUCT.MOL.BIOL. V. 17 1312 2010REFN ISSN 1545-9993PMID 20972443DOI 10.1038/NSMB.1938 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3fay IQGAP1 crystal structure of the gap-related domain of iqgap1 2.2Å AUTH V.B.KURELLA,J.M.RICHARD,C.L.PARKE,L.F.LECOUR,AUTH 2 H.D.BELLAMY,D.K.WORTHYLAKETITL CRYSTAL STRUCTURE OF THE GTPASE-ACTIVATINGTITL 2 PROTEIN-RELATED DOMAIN FROM IQGAP1.REF J.BIOL.CHEM. V. 284 14857 2009REFN ISSN 0021-9258PMID 19321438DOI 10.1074/JBC.M808974200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4m4r EPHA4 epha4 ectodomain complex with ephrin a5 3.13Å AUTH K.XU,D.TZVETKOVA-ROBEV,Y.XU,Y.GOLDGUR,Y.P.CHAN,J.P.HIMANEN,AUTH 2 D.B.NIKOLOVTITL INSIGHTS INTO EPH RECEPTOR TYROSINE KINASE ACTIVATION FROMTITL 2 CRYSTAL STRUCTURES OF THE EPHA4 ECTODOMAIN AND ITS COMPLEXTITL 3 WITH EPHRIN-A5.REF PROC.NATL.ACAD.SCI.USA V. 110 14634 2013REFN ISSN 0027-8424PMID 23959867DOI 10.1073/PNAS.1311000110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4go6 HCFC1 crystal structure of hcf-1 self-association sequence 1 2.7Å AUTH J.PARK,F.LAMMERS,W.HERR,J.SONGTITL HCF-1 SELF-ASSOCIATION VIA AN INTERDIGITATED FN3 STRUCTURETITL 2 FACILITATES TRANSCRIPTIONAL REGULATORY COMPLEX FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 109 17430 2012REFN ISSN 0027-8424PMID 23045687DOI 10.1073/PNAS.1208378109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3eh2 SEC24C crystal structure of the human copii-coat protein sec24c 2.35Å AUTH J.D.MANCIAS,J.GOLDBERGTITL STRUCTURAL BASIS OF CARGO MEMBRANE PROTEINTITL 2 DISCRIMINATION BY THE HUMAN COPII COAT MACHINERY.REF EMBO J. V. 27 2918 2008REFN ISSN 0261-4189PMID 18843296DOI 10.1038/EMBOJ.2008.208 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ys1 DNM2 solution structure of the ph domain of dynamin-2 from human -1.0Å AUTH H.LI,M.SATO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF DYNAMIN-2TITL 2 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ds6 ARHGDIB crystal structure of a rac-rhogdi complex 2.35Å AUTH K.SCHEFFZEK,I.STEPHAN,O.N.JENSEN,D.ILLENBERGER,AUTH 2 P.GIERSCHIKTITL THE RAC-RHOGDI COMPLEX AND THE STRUCTURAL BASISTITL 2 FOR THE REGULATION OF RHO PROTEINS BY RHOGDI.REF NAT.STRUCT.BIOL. V. 7 122 2000REFN ISSN 1072-8368PMID 10655614DOI 10.1038/72392 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3dem MASP1 cub1-egf-cub2 domain of human masp-1/3 2.3Å AUTH F.TEILLET,C.GABORIAUD,M.LACROIX,L.MARTIN,G.J.ARLAUD,AUTH 2 N.M.THIELENSTITL CRYSTAL STRUCTURE OF THE CUB1-EGF-CUB2 DOMAIN OF HUMANTITL 2 MASP-1/3 AND IDENTIFICATION OF ITS INTERACTION SITES WITHTITL 3 MANNAN-BINDING LECTIN AND FICOLINSREF J.BIOL.CHEM. V. 283 25715 2008REFN ISSN 0021-9258PMID 18596036DOI 10.1074/JBC.M803551200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2yho UBE2D1 the idol-ube2d complex mediates sterol-dependent degradation of the ldl receptor 2.1Å AUTH L.ZHANG,L.FAIRALL,B.T.GOULT,A.C.CALKIN,C.HONG,C.J.MILLARD,AUTH 2 P.TONTONOZ,J.W.SCHWABETITL THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENTTITL 2 DEGRADATION OF THE LDL RECEPTOR.REF GENES DEV. V. 25 1262 2011REFN ISSN 0890-9369PMID 21685362DOI 10.1101/GAD.2056211 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]