General Structure Information
| PDB ID | 1qk9 |
| HGNC Gene Label(s) | MECP2 |
| Structure Name | the solution structure of the domain from mecp2 that binds to methylated dna |
| Resolution | -1.0Å |
| Reference | AUTH R.I.D.WAKEFIELD,B.O.SMITH,X.NAN,A.FREE,A.SOTERIOU,AUTH 2 D.UHRIN,A.P.BIRD,P.N.BARLOWTITL THE SOLUTION STRUCTURE OF THE DOMAIN FROM MECP2TITL 2 THAT BINDS TO METHYLATED DNAREF J.MOL.BIOL. V. 291 1055 1999REFN ISSN 0022-2836 70PMID 10518942DOI 10.1006/JMBI.1999.3023 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 90 |
| Number Of SNVs | 10 |
| Number Of Permutations | 7374 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.267 |
| p-value | 0.068 |
ClinVar
| Number Of Residues | 90 |
| Number Of SNVs | 9 |
| Number Of Permutations | 6529 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.917 |
| p-value | 0.063 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 10 |
| Number Of ClinVar SNVs | 6 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.222 |
| p-value | 0.036 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
