Assessment of Structural Intolerance and Durability
General Structure Information 4f7s CDK8 crystal structure of human cdk8/cycc in the dmg-in conformation 2.2Å AUTH E.V.SCHNEIDER,J.BOTTCHER,R.HUBER,K.MASKOS,L.NEUMANNTITL STRUCTURE-KINETIC RELATIONSHIP STUDY OF CDK8/CYCC SPECIFICTITL 2 COMPOUNDS.REF PROC.NATL.ACAD.SCI.USA V. 110 8081 2013REFN ISSN 0027-8424PMID 23630251DOI 10.1073/PNAS.1305378110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o10 CSRP3 solution structure of the n-terminal lim domain of mlp/crp3 -1.0Å AUTH T.SCHALLUS,G.STIER,K.FEHER,C.MUHLE-GOLLTITL STRUCTURE OF THE MUSCULAR LIM PROTEIN MLP AND ITSTITL 2 INTERACTION WITH ACTININREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1t77 LRBA crystal structure of the ph-beach domains of human lrba/bgl 2.4Å AUTH D.GEBAUER,J.LI,G.JOGL,Y.SHEN,D.G.MYSZKA,L.TONGTITL CRYSTAL STRUCTURE OF THE PH-BEACH DOMAINS OF HUMANTITL 2 LRBA/BGLREF BIOCHEMISTRY V. 43 14873 2004REFN ISSN 0006-2960PMID 15554694DOI 10.1021/BI049498Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lwk CRYBA4 crystal structure of human beta-crystallin a4 (cryba4) 1.7Å AUTH A.CHAIKUAD,N.SHAFQAT,T.KROJER,W.W.YUE,R.COCKING,M.VOLLMAR,AUTH 2 J.R.C.MUNIZ,A.C.W.PIKE,F.VON DELFT,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA-CRYSTALLIN A4 (CRYBA4)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gro PPT1 human palmitoyl-protein thioesterase 1 2.53Å AUTH E.DOBROVETSKY,A.SEITOVA,Y.TONG,W.TEMPEL,A.DONG,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,D.COSSAR,H.PARKTITL HUMAN PALMITOYL-PROTEIN THIOESTERASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4a4l PLK1 crystal structure of polo-like kinase 1 in complex with a 5-(2-amino-pyrimidin-4-yl)-1h-pyrrole inhibitor 2.35Å AUTH M.CARUSO,B.VALSASINA,D.BALLINARI,J.A.BERTRAND,M.G.BRASCA,AUTH 2 M.CALDARELLI,P.CAPPELLA,F.FIORENTINI,L.M.GIANELLINI,AUTH 3 A.SCOLARO,I.BERIATITL 5-(2-AMINO-PYRIMIDIN-4-YL)-1H-PYRROLE AND 2-(2-AMINO-TITL 2 PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-PYRROLO[3,2-C]PYRIDIN-4-TITL 3 ONE DERIVATIVES AS NEW CLASSES OF SELECTIVE AND ORALLYTITL 4 AVAILABLE POLO-LIKE KINASE 1 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 96 2012REFN ISSN 0960-894XPMID 22154349DOI 10.1016/J.BMCL.2011.11.065 Variant […]
General Structure Information 1ls6 SULT1A1 human sult1a1 complexed with pap and p-nitrophenol 1.9Å AUTH N.U.GAMAGE,R.G.DUGGLEBY,A.C.BARNETT,M.TRESILLIAN,AUTH 2 C.F.LATHAM,N.E.LIYOU,M.E.MCMANUS,J.L.MARTINTITL STRUCTURE OF A HUMAN CARCINOGEN-CONVERTING ENZYME,TITL 2 SULT1A1. STRUCTURAL AND KINETIC IMPLICATIONS OFTITL 3 SUBSTRATE INHIBITION.REF J.BIOL.CHEM. V. 278 7655 2003REFN ISSN 0021-9258PMID 12471039DOI 10.1074/JBC.M207246200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2w8r ALDH5A1 the crystal structure of human ssadh in complex with nad+ 2.4Å AUTH Y.-G.KIM,S.LEE,O.-S.KWON,S.-Y.PARK,S.-J.LEE,AUTH 2 B.-J.PARK,K.-J.KIMTITL REDOX-SWITCH MODULATION OF HUMAN SSADH BY DYNAMICTITL 2 CATALYTIC LOOP.REF EMBO J. V. 28 959 2009REFN ISSN 0261-4189PMID 19300440DOI 10.1038/EMBOJ.2009.40 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fby COMP the crystal structure of the signature domain of cartilage oligomeric matrix protein. 3.15Å AUTH K.TAN,M.DUQUETTE,A.JOACHIMIAK,J.LAWLERTITL THE CRYSTAL STRUCTURE OF THE SIGNATURE DOMAIN OF CARTILAGETITL 2 OLIGOMERIC MATRIX PROTEIN: IMPLICATIONS FOR COLLAGEN,TITL 3 GLYCOSAMINOGLYCAN AND INTEGRIN BINDING.REF FASEB J. V. 23 2490 2009REFN ISSN 0892-6638PMID 19276170DOI 10.1096/FJ.08-128090 Variant Set Distributions Ripley’s […]
General Structure Information 2vxo GMPS human gmp synthetase in complex with xmp 2.5Å AUTH M.WELIN,L.LEHTIO,A.JOHANSSON,S.FLODIN,T.NYMAN,AUTH 2 L.TRESAUGUES,M.HAMMARSTROM,S.GRASLUND,P.NORDLUNDTITL SUBSTRATE SPECIFICITY AND OLIGOMERIZATION OF HUMANTITL 2 GMP SYNTHETASEREF J.MOL.BIOL. V. 425 4323 2013REFN ISSN 0022-2836PMID 23816837DOI 10.1016/J.JMB.2013.06.032 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants