Assessment of Structural Intolerance and Durability
General Structure Information 3gf9 ITSN2 crystal structure of human intersectin 2 rhogef domain 2.5Å AUTH Y.SHEN,Y.TONG,W.TEMPEL,Y.LI,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 RHOGEFTITL 2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ft8 NXF1 crystal structure of the rna-binding domain of the mrna export factor tap 3.15Å AUTH E.LIKER,E.FERNANDEZ,E.IZAURRALDE,E.CONTITITL THE STRUCTURE OF THE MRNA EXPORT FACTOR TAPTITL 2 REVEALS A CIS ARRANGEMENT OF A NON-CANONICAL RNPTITL 3 DOMAIN AND AN LRR DOMAIN.REF EMBO J. V. 19 5587 2000REFN ISSN 0261-4189PMID 11060011DOI 10.1093/EMBOJ/19.21.5587 Variant Set […]
General Structure Information 2qq8 TBC1D14 crystal structure of the putative rabgap domain of human tbc1 domain family member 14 2.0Å AUTH Y.TONG,W.TEMPEL,S.DIMOV,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE PUTATIVE RABGAP DOMAIN OFTITL 2 HUMAN TBC1 DOMAIN FAMILY MEMBER 14.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3h5c SERPINA10 x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1wiz SATB2 solution structure of the first cut domain of kiaa1034 protein -1.0Å AUTH K.INOUE,S.NAMEKI,F.HAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST CUT DOMAIN OFTITL 2 KIAA1034 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b1u PADI4 crystal structure of human peptidylarginine deiminase 4 in complex with o-f-amidine 2.1Å AUTH C.P.CAUSEY,J.E.JONES,J.L.SLACK,D.KAMEI,L.E.JONES JR,AUTH 2 V.SUBRAMANIAN,B.KNUCKLEY,P.EBRAHIMI,A.A.CHUMANEVICH,Y.LUO,AUTH 3 H.HASHIMOTO,M.SATO,L.J.HOFSETH,P.R.THOMPSONTITL THE DEVELOPMENT OFTITL 2 N-ALPHA-(2-CARBOXYL)BENZOYL-N(5)-(2-FLUORO-1-IMINOETHYL)-L-TITL 3 ORNITHINE AMIDE (O-F-AMIDINE) ANDTITL 4 N-ALPHA-(2-CARBOXYL)BENZOYL-N(5)-(2-CHLORO-1-IMINOETHYL)-L-TITL 5 ORNITHINE AMIDE (O-CL-AMIDINE) AS SECOND GENERATION PROTEINTITL 6 ARGININE DEIMINASE (PAD) INHIBITORSREF J.MED.CHEM. V. 54 6919 2011REFN ISSN […]
General Structure Information 4mqf GABBR1 crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist 2-hydroxysaclofen 2.22Å AUTH Y.GENG,M.BUSH,L.MOSYAK,F.WANG,Q.R.FANTITL STRUCTURAL MECHANISM OF LIGAND ACTIVATION IN HUMAN GABA(B)TITL 2 RECEPTOR.REF NATURE V. 504 254 2013REFN ISSN 0028-0836PMID 24305054DOI 10.1038/NATURE12725 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3u5n TRIM33 crystal structure of the complex of trim33 phd-bromo and h3(1-20) k9me3k14ac histone peptide 1.95Å AUTH Q.XI,Z.WANG,A.I.ZAROMYTIDOU,X.H.ZHANG,L.F.CHOW-TSANG,AUTH 2 J.X.LIU,H.KIM,A.BARLAS,K.MANOVA-TODOROVA,V.KAARTINEN,AUTH 3 L.STUDER,W.MARK,D.J.PATEL,J.MASSAGUETITL A POISED CHROMATIN PLATFORM FOR TGF-BETA ACCESS TO MASTERTITL 2 REGULATORSREF CELL(CAMBRIDGE,MASS.) V. 147 1511 2011REFN ISSN 0092-8674PMID 22196728DOI 10.1016/J.CELL.2011.11.032 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3vfd SPAST human spastin aaa domain 3.3Å AUTH J.L.TAYLOR,S.R.WHITE,B.LAURING,F.J.KULLTITL CRYSTAL STRUCTURE OF THE HUMAN SPASTIN AAA DOMAIN.REF J.STRUCT.BIOL. V. 179 133 2012REFN ISSN 1047-8477PMID 22446388DOI 10.1016/J.JSB.2012.03.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4h9p DAXX complex structure 3 of daxx/h3.3(sub5,g90a)/h4 2.2Å AUTH S.J.ELSASSER,H.HUANG,P.W.LEWIS,J.W.CHIN,D.C.ALLIS,D.J.PATELTITL DAXX CHAPERONE ENVELOPS AN H3.3/H4 DIMER DICTATINGTITL 2 H3.3-SPECIFIC READ OUTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants