General Structure Information
| PDB ID | 3gf9 |
| HGNC Gene Label(s) | ITSN2 |
| Structure Name | crystal structure of human intersectin 2 rhogef domain |
| Resolution | 2.5Å |
| Reference | AUTH Y.SHEN,Y.TONG,W.TEMPEL,Y.LI,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 RHOGEFTITL 2 DOMAINREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 182 |
| Number Of SNVs | 52 |
| Number Of Permutations | 7625 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.051 |
| p-value | 0.245 |
COSMIC
| Number Of Residues | 182 |
| Number Of SNVs | 4 |
| Number Of Permutations | 484 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.167 |
| p-value | 0.72 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 52 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.149 |
| p-value | 0.757 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
