Assessment of Structural Intolerance and Durability
General Structure Information 1ll8 PASK structure and interactions of pas kinase n-terminal pas domain: model for intramolecular kinase regulation -1.0Å AUTH C.A.AMEZCUA,S.M.HARPER,J.RUTTER,K.H.GARDNERTITL STRUCTURE AND INTERACTIONS OF PAS KINASETITL 2 N-TERMINAL PAS DOMAIN: MODEL FOR INTRAMOLECULARTITL 3 KINASE REGULATION.REF STRUCTURE V. 10 1349 2002REFN ISSN 0969-2126PMID 12377121DOI 10.1016/S0969-2126(02)00857-2 Variant Set Distributions Mapped Variants
General Structure Information 4gs9 EPAS1 crystal structure of the high affinity heterodimer of hif2 alpha and arnt c-terminal pas domains in complex with an inactive benzoxadiazole antagonist 1.72Å AUTH J.L.ROGERS,L.BAYEH,T.H.SCHEUERMANN,J.LONGGOOD,J.KEY,AUTH 2 J.NAIDOO,L.MELITO,C.SHOKRI,D.E.FRANTZ,R.K.BRUICK,AUTH 3 K.H.GARDNER,J.B.MACMILLAN,U.K.TAMBARTITL DEVELOPMENT OF INHIBITORS OF THE PAS-B DOMAIN OF THE HIF-2TITL 2 ALPHA TRANSCRIPTION FACTORREF J.MED.CHEM. V. 56 1739 2013REFN ISSN 0022-2623PMID […]
General Structure Information 3dls PASK crystal structure of human pas kinase bound to adp 2.3Å AUTH C.K.KIKANI,S.A.ANTONYSAMY,J.B.BONANNO,R.ROMERO,F.F.ZHANG,AUTH 2 M.RUSSELL,T.GHEYI,M.IIZUKA,S.EMTAGE,J.M.SAUDER,B.E.TURK,AUTH 3 S.K.BURLEY,J.RUTTERTITL STRUCTURAL BASES OF PAS DOMAIN-REGULATED KINASE (PASK)TITL 2 ACTIVATION IN THE ABSENCE OF ACTIVATION LOOPTITL 3 PHOSPHORYLATION.REF J.BIOL.CHEM. V. 285 41034 2010REFN ISSN 0021-9258PMID 20943661DOI 10.1074/JBC.M110.157594 Variant Set Distributions Mapped Variants
General Structure Information 4h6j HIF1A identification of cys 255 in hif-1 as a novel site for development of covalent inhibitors of hif-1 /arnt pasb domain protein-protein interaction. 1.52Å AUTH R.CARDOSO,R.LOVE,C.L.NILSSON,S.BERGQVIST,D.NOWLIN,J.YAN,AUTH 2 K.K.LIU,J.ZHU,P.CHEN,Y.L.DENG,H.J.DYSON,M.J.GREIG,A.BROOUNTITL IDENTIFICATION OF CYS255 IN HIF-1 ALPHA AS A NOVEL SITE FORTITL 2 DEVELOPMENT OF COVALENT INHIBITORS OF HIF-1 ALPHA /ARNT PASBTITL 3 DOMAIN […]
General Structure Information 2l4r KCNH2 nmr solution structure of the n-terminal pas domain of herg -1.0Å AUTH Q.LI,S.GAYEN,A.S.CHEN,Q.HUANG,M.RAIDA,C.KANGTITL NMR SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF HERG ANDTITL 2 ITS INTERACTION WITH THE S4-S5 LINKER.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 403 126 2010REFN ISSN 0006-291XPMID 21055387DOI 10.1016/J.BBRC.2010.10.132 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l4r KCNH2 nmr solution structure of the n-terminal pas domain of herg -1.0Å AUTH Q.LI,S.GAYEN,A.S.CHEN,Q.HUANG,M.RAIDA,C.KANGTITL NMR SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF HERG ANDTITL 2 ITS INTERACTION WITH THE S4-S5 LINKER.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 403 126 2010REFN ISSN 0006-291XPMID 21055387DOI 10.1016/J.BBRC.2010.10.132 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants