General Structure Information 4ie5 FTO crystal structure of the human fat mass and obesity associated protein (fto) in complex with n-[(3-hydroxypyridin-2-yl)carbonyl]glycine (md6) 1.95Å AUTH W.S.AIK,M.DEMETRIADES,M.K.K.HAMDAN,E.A.L.BAGG,K.K.YEOH,AUTH 2 C.LEJEUNE,Z.ZHANG,M.A.MCDONOUGH,C.J.SCHOFIELDTITL STRUCTURAL BASIS FOR INHIBITION OF THE FAT MASS AND OBESITYTITL 2 ASSOCIATED PROTEIN (FTO)REF J.MED.CHEM. V. 56 3680 2013REFN ISSN 0022-2623PMID 23547775DOI 10.1021/JM400193D Variant Set Distributions Mapped Variants
General Structure Information 4nj4 ALKBH5 crystal structure of human alkbh5 2.02Å AUTH W.AIK,J.S.SCOTTI,H.CHOI,L.GONG,M.DEMETRIADES,C.J.SCHOFIELD,AUTH 2 M.A.MCDONOUGHTITL STRUCTURE OF HUMAN RNA N6-METHYLADENINE DEMETHYLASE ALKBH5TITL 2 PROVIDES INSIGHTS INTO ITS MECHANISMS OF NUCLEIC ACIDTITL 3 RECOGNITION AND DEMETHYLATION.REF NUCLEIC ACIDS RES. V. 42 4741 2014REFN ISSN 0305-1048PMID 24489119DOI 10.1093/NAR/GKU085 Variant Set Distributions Mapped Variants
General Structure Information 4lce CTBP1 ctbp1 in complex with substrate mtob 2.38Å AUTH B.J.HILBERT,S.R.GROSSMANN,C.A.SCHIFFER,W.E.ROYERTITL CRYSTAL STRUCTURES OF HUMAN CTBP IN COMPLEX WITH SUBSTRATETITL 2 MTOB REVEAL ACTIVE SITE FEATURES USEFUL FOR INHIBITORTITL 3 DESIGN.REF FEBS LETT. V. 588 1743 2014REFN ISSN 0014-5793PMID 24657618DOI 10.1016/J.FEBSLET.2014.03.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4lcj CTBP2 ctbp2 in complex with substrate mtob 2.86Å AUTH B.J.HILBERT,S.R.GROSSMANN,C.A.SCHIFFER,W.E.ROYERTITL CRYSTAL STRUCTURES OF HUMAN CTBP IN COMPLEX WITH SUBSTRATETITL 2 MTOB REVEAL ACTIVE SITE FEATURES USEFUL FOR INHIBITORTITL 3 DESIGN.REF FEBS LETT. V. 588 1743 2014REFN ISSN 0014-5793PMID 24657618DOI 10.1016/J.FEBSLET.2014.03.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4lce CTBP1 ctbp1 in complex with substrate mtob 2.38Å AUTH B.J.HILBERT,S.R.GROSSMANN,C.A.SCHIFFER,W.E.ROYERTITL CRYSTAL STRUCTURES OF HUMAN CTBP IN COMPLEX WITH SUBSTRATETITL 2 MTOB REVEAL ACTIVE SITE FEATURES USEFUL FOR INHIBITORTITL 3 DESIGN.REF FEBS LETT. V. 588 1743 2014REFN ISSN 0014-5793PMID 24657618DOI 10.1016/J.FEBSLET.2014.03.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4lcj CTBP2 ctbp2 in complex with substrate mtob 2.86Å AUTH B.J.HILBERT,S.R.GROSSMANN,C.A.SCHIFFER,W.E.ROYERTITL CRYSTAL STRUCTURES OF HUMAN CTBP IN COMPLEX WITH SUBSTRATETITL 2 MTOB REVEAL ACTIVE SITE FEATURES USEFUL FOR INHIBITORTITL 3 DESIGN.REF FEBS LETT. V. 588 1743 2014REFN ISSN 0014-5793PMID 24657618DOI 10.1016/J.FEBSLET.2014.03.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4ja8 IDH2 complex of mitochondrial isocitrate dehydrogenase r140q mutant with agi-6780 inhibitor 1.55Å AUTH F.WANG,J.TRAVINS,B.DELABARRE,V.PENARD-LACRONIQUE,S.SCHALM,AUTH 2 E.HANSEN,K.STRALEY,A.KERNYTSKY,W.LIU,C.GLISER,H.YANG,AUTH 3 S.GROSS,E.ARTIN,V.SAADA,E.MYLONAS,C.QUIVORON,AUTH 4 J.POPOVICI-MULLER,J.O.SAUNDERS,F.G.SALITURO,S.YAN,S.MURRAY,AUTH 5 W.WEI,Y.GAO,L.DANG,M.DORSCH,S.AGRESTA,D.P.SCHENKEIN,AUTH 6 S.A.BILLER,S.M.SU,S.DE BOTTON,K.E.YENTITL TARGETED INHIBITION OF MUTANT IDH2 IN LEUKEMIA CELLS INDUCESTITL 2 CELLULAR DIFFERENTIATION.REF SCIENCE V. 340 622 2013REFN ISSN 0036-8075PMID 23558173DOI 10.1126/SCIENCE.1234769 Variant Set Distributions Ripley’s K […]
General Structure Information 4h80 ALDH3A1 crystal structure of human aldh3a1 with its isozyme selective inhibitor – n-[4-(4-methylsulfonyl-2-nitroanilino)phenyl]acetamide 2.5Å AUTH B.PARAJULI,T.GEORGIADIS,M.L.FISHEL,T.D.HURLEYTITL KINETIC AND STRUCTURAL CHARACTERIZATION OF A SELECTIVETITL 2 INHIBITOR FOR HUMAN ALDH3A1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4dbu AKR1C3 crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (akr1c3) in complex with nadp+ and 3-((4 -(trifluoromethyl)phenyl) amino)benzoic acid 2.53Å AUTH M.CHEN,A.O.ADENIJI,B.M.TWENTER,J.D.WINKLER,D.W.CHRISTIANSON,AUTH 2 T.M.PENNINGTITL CRYSTAL STRUCTURES OF AKR1C3 CONTAINING ANTITL 2 N-(ARYL)AMINO-BENZOATE INHIBITOR AND A BIFUNCTIONAL AKR1C3TITL 3 INHIBITOR AND ANDROGEN RECEPTOR ANTAGONIST. THERAPEUTICTITL 4 LEADS FOR CASTRATE RESISTANT PROSTATE CANCER.REF […]