General Structure Information
| PDB ID | 4lce |
| HGNC Gene Label(s) | CTBP1 |
| Structure Name | ctbp1 in complex with substrate mtob |
| Resolution | 2.38Å |
| Reference | AUTH B.J.HILBERT,S.R.GROSSMANN,C.A.SCHIFFER,W.E.ROYERTITL CRYSTAL STRUCTURES OF HUMAN CTBP IN COMPLEX WITH SUBSTRATETITL 2 MTOB REVEAL ACTIVE SITE FEATURES USEFUL FOR INHIBITORTITL 3 DESIGN.REF FEBS LETT. V. 588 1743 2014REFN ISSN 0014-5793PMID 24657618DOI 10.1016/J.FEBSLET.2014.03.026 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 326 |
| Number Of SNVs | 41 |
| Number Of Permutations | 7784 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.317 |
| p-value | 0.742 |
COSMIC
| Number Of Residues | 326 |
| Number Of SNVs | 7 |
| Number Of Permutations | 2012 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.048 |
| p-value | 0.921 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 41 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.317 |
| p-value | 0.353 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
