Assessment of Structural Intolerance and Durability
General Structure Information 4k9w CYP3A4 complex of human cyp3a4 with a desoxyritonavir analog 2.4Å AUTH I.F.SEVRIOUKOVA,T.L.POULOSTITL DISSECTING CYTOCHROME P450 3A4-LIGAND INTERACTIONS USINGTITL 2 RITONAVIR ANALOGUES.REF BIOCHEMISTRY V. 52 4474 2013REFN ISSN 0006-2960PMID 23746300DOI 10.1021/BI4005396 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ruk CYP17A1 human cytochrome p450 cyp17a1 in complex with abiraterone 2.6Å AUTH N.M.DEVORE,E.E.SCOTTTITL STRUCTURES OF CYTOCHROME P450 17A1 WITH PROSTATE CANCERTITL 2 DRUGS ABIRATERONE AND TOK-001.REF NATURE V. 482 116 2012REFN ISSN 0028-0836PMID 22266943DOI 10.1038/NATURE10743 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4jnk LDHA lactate dehydrogenase a in complex with inhibitor compound 22 1.9Å AUTH P.S.DRAGOVICH,B.P.FAUBER,L.B.CORSON,C.Z.DING,C.EIGENBROT,AUTH 2 H.GE,A.M.GIANNETTI,T.HUNSAKER,S.LABADIE,Y.LIU,S.MALEK,B.PAN,AUTH 3 D.PETERSON,K.PITTS,H.E.PURKEY,S.SIDERIS,M.ULTSCH,AUTH 4 E.VANDERPORTEN,B.WEI,Q.XU,I.YEN,Q.YUE,H.ZHANG,X.ZHANGTITL IDENTIFICATION OF SUBSTITUTEDTITL 2 2-THIO-6-OXO-1,6-DIHYDROPYRIMIDINES AS INHIBITORS OF HUMANTITL 3 LACTATE DEHYDROGENASE.REF BIOORG.MED.CHEM.LETT. V. 23 3186 2013REFN ISSN 0960-894XPMID 23628333DOI 10.1016/J.BMCL.2013.04.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4jih AKR1B10 crystal structure of akr1b10 complexed with nadp+ and epalrestat 2.3Å AUTH L.ZHANG,H.ZHANG,Y.ZHAO,Z.LI,S.CHEN,J.ZHAI,Y.CHEN,W.XIE,AUTH 2 Z.WANG,Q.LI,X.ZHENG,X.HUTITL INHIBITOR SELECTIVITY BETWEEN ALDO-KETO REDUCTASETITL 2 SUPERFAMILY MEMBERS AKR1B10 AND AKR1B1: ROLE OF TRP112TITL 3 (TRP111).REF FEBS LETT. V. 587 3681 2013REFN ISSN 0014-5793PMID 24100137DOI 10.1016/J.FEBSLET.2013.09.031 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]