Assessment of Structural Intolerance and Durability
General Structure Information 2k6g RFC1 solution structure of the dna binding brct domain from the large subunit of human replication factor c -1.0Å AUTH M.KOBAYASHI,E.AB,A.M.J.J.BONVIN,G.SIEGALTITL SOLUTION STRUCTURE OF THE DNA BOUND BRCT DOMAINTITL 2 FROM HUMAN REPLICATION FACTOR C P140REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fmp NUP214 crystal structure of the nucleoporin nup214 in complex with the dead- box helicase ddx19 3.19Å AUTH J.NAPETSCHNIG,S.A.KASSUBE,E.W.DEBLER,R.W.WONG,G.BLOBEL,AUTH 2 A.HOELZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE INTERACTIONTITL 2 BETWEEN THE NUCLEOPORIN NUP214 AND THE DEAD-BOX HELICASETITL 3 DDX19.REF PROC.NATL.ACAD.SCI.USA V. 106 3089 2009REFN ISSN 0027-8424PMID 19208808DOI 10.1073/PNAS.0813267106 Variant Set Distributions Ripley’s […]
General Structure Information 3ihp USP5 covalent ubiquitin-usp5 complex 2.8Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL COVALENT UBIQUITIN-USP5 COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3n3k USP8 the catalytic domain of usp8 in complex with a usp8 specific inhibitor 2.6Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K […]
General Structure Information 3dzy PPARG intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with rosiglitazone, 9-cis retinoic acid and ncoa2 peptide 3.1Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 3fdt CBX5 crystal structure of the complex of human chromobox homolog 5 (cbx5) with h3k9(me)3 peptide 2.0Å AUTH L.KAUSTOV,H.OUYANG,M.AMAYA,A.LEMAK,N.NADY,S.DUAN,G.A.WASNEY,AUTH 2 Z.LI,M.VEDADI,M.SCHAPIRA,J.MIN,C.H.ARROWSMITHTITL RECOGNITION AND SPECIFICITY DETERMINANTS OF THE HUMAN CBXTITL 2 CHROMODOMAINS.REF J.BIOL.CHEM. V. 286 521 2011REFN ISSN 0021-9258PMID 21047797DOI 10.1074/JBC.M110.191411 Variant Set Distributions Mapped Variants
General Structure Information 3bim BCL6 crystal structure of the bcl6 btb domain dimer in complex with the bcor bbd corepressor peptide 2.6Å AUTH A.F.GHETU,C.M.CORCORAN,L.CERCHIETTI,V.J.BARDWELL,AUTH 2 A.MELNICK,G.G.PRIVETITL STRUCTURE OF A BCOR COREPRESSOR PEPTIDE IN COMPLEXTITL 2 WITH THE BCL6 BTB DOMAIN DIMER.REF MOL.CELL V. 29 384 2008REFN ISSN 1097-2765PMID 18280243DOI 10.1016/J.MOLCEL.2007.12.026 Variant Set Distributions Mapped Variants
General Structure Information 3umn LMNB1 crystal structure of lamin-b1 2.0Å AUTH J.RUAN,C.XU,C.BIAN,R.LAM,J.P.WANG,J.KANIA,J.MIN,J.ZANGTITL CRYSTAL STRUCTURES OF THE COIL 2B FRAGMENT AND THE GLOBULARTITL 2 TAIL DOMAIN OF HUMAN LAMIN B1.REF FEBS LETT. V. 586 314 2012REFN ISSN 0014-5793PMID 22265972DOI 10.1016/J.FEBSLET.2012.01.007 Variant Set Distributions Mapped Variants
General Structure Information 3cjw NR2F2 crystal structure of the human coup-tfii ligand binding domain 1.48Å AUTH S.W.KRUSE,K.SUINO-POWELL,X.E.ZHOU,J.E.KRETSCHMAN,AUTH 2 R.REYNOLDS,C.VONRHEIN,Y.XU,L.WANG,S.Y.TSAI,AUTH 3 M.J.TSAI,H.E.XUTITL IDENTIFICATION OF COUP-TFII ORPHAN NUCLEARTITL 2 RECEPTOR AS A RETINOIC ACID-ACTIVATED RECEPTOR.REF PLOS BIOL. V. 6 E227 2008REFN ISSN 1544-9173PMID 18798693DOI 10.1371/JOURNAL.PBIO.0060227 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3tyy LMNB1 crystal structure of human lamin-b1 coil 2 segment 2.4Å AUTH J.RUAN,C.XU,C.BIAN,R.LAM,J.P.WANG,J.KANIA,J.MIN,J.ZANGTITL CRYSTAL STRUCTURES OF THE COIL 2B FRAGMENT AND THE GLOBULARTITL 2 TAIL DOMAIN OF HUMAN LAMIN B1.REF FEBS LETT. V. 586 314 2012REFN ISSN 0014-5793PMID 22265972DOI 10.1016/J.FEBSLET.2012.01.007 Variant Set Distributions Mapped Variants