Assessment of Structural Intolerance and Durability
General Structure Information 3bdl SND1 crystal structure of a truncated human tudor-sn 1.9Å AUTH C.L.LI,W.Z.YANG,Y.P.CHEN,H.S.YUANTITL STRUCTURAL AND FUNCTIONAL INSIGHTS INTO HUMANTITL 2 TUDOR-SN, A KEY COMPONENT LINKING RNA INTERFERENCETITL 3 AND EDITING.REF NUCLEIC ACIDS RES. V. 36 3579 2008REFN ISSN 0305-1048PMID 18453631DOI 10.1093/NAR/GKN236 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3v2b PARP15 human poly(adp-ribose) polymerase 15 (artd7, bal3), macro domain 2 in complex with adenosine-5-diphosphoribose 2.2Å AUTH A.H.FORST,T.KARLBERG,N.HERZOG,A.G.THORSELL,A.GROSS,AUTH 2 K.L.FEIJS,P.VERHEUGD,P.KURSULA,B.NIJMEIJER,E.KREMMER,AUTH 3 H.KLEINE,A.G.LADURNER,H.SCHULER,B.LUSCHERTITL RECOGNITION OF MONO-ADP-RIBOSYLATED ARTD10 SUBSTRATES BYTITL 2 ARTD8 MACRODOMAINS.REF STRUCTURE V. 21 462 2013REFN ISSN 0969-2126PMID 23473667DOI 10.1016/J.STR.2012.12.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3fga SGOL1 structural basis of pp2a and sgo interaction 2.7Å AUTH Z.XU,B.CETIN,M.ANGER,U.S.CHO,W.HELMHART,K.NASMYTH,W.XUTITL STRUCTURE AND FUNCTION OF THE PP2A-SHUGOSHIN INTERACTIONREF MOL.CELL V. 35 426 2009REFN ISSN 1097-2765PMID 19716788DOI 10.1016/J.MOLCEL.2009.06.031 Variant Set Distributions Mapped Variants
General Structure Information 3iai CA9 crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase ix 2.2Å AUTH V.ALTERIO,M.HILVO,A.DI FIORE,C.T.SUPURAN,P.PAN,S.PARKKILA,AUTH 2 A.SCALONI,J.PASTOREK,S.PASTOREKOVA,C.PEDONE,A.SCOZZAFAVA,AUTH 3 S.M.MONTI,G.DE SIMONETITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THETITL 2 TUMOR-ASSOCIATED HUMAN CARBONIC ANHYDRASE IX.REF PROC.NATL.ACAD.SCI.USA V. 106 16233 2009REFN ISSN 0027-8424PMID 19805286DOI 10.1073/PNAS.0908301106 Variant Set Distributions Mapped Variants
General Structure Information 3bo5 SETMAR crystal structure of methyltransferase domain of human histone-lysine n-methyltransferase setmar 1.59Å AUTH H.WU,V.V.LUNIN,H.REN,E.DOBROVETSKY,J.WEIGELT,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR IN COMPLEX WITHTITL 3 ADOHCY.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kdd CDCA8 solution structure of the conserved c-terminal dimerization domain of borealin -1.0Å AUTH E.BOURHIS,A.LINGEL,Q.PHUNG,W.J.FAIRBROTHER,AUTH 2 A.G.COCHRANTITL PHOSPHORYLATION OF A BOREALIN DIMERIZATION DOMAINTITL 2 IS REQUIRED FOR PROPER CHROMOSOME SEGREGATION.REF BIOCHEMISTRY V. 48 6783 2009REFN ISSN 0006-2960PMID 19530738DOI 10.1021/BI900530V Variant Set Distributions Mapped Variants
General Structure Information 3blj PARP15 crystal structure of human poly(adp-ribose) polymerase 15, catalytic fragment 2.2Å AUTH T.KARLBERG,M.KLEPSCH,A.G.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASE ACTIVITYTITL 2 IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGER ANTIVIRALTITL 3 PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3b6y IFI16 crystal structure of the second hin-200 domain of interferon-inducible protein 16 2.35Å AUTH J.C.C.LIAO,R.LAM,M.RAVICHANDRAN,S.DUAN,W.TEMPEL,AUTH 2 N.Y.CHIRGADZE,C.H.ARROWSMITHTITL CRYSTAL STRUCTURE ANALYSIS OF THE SECOND HIN DOMAIN OFTITL 2 IFI16.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3eij PDCD4 crystal structure of pdcd4 2.8Å AUTH P.G.LOH,H.-S.YANG,M.A.WALSH,Q.WANG,X.WANG,Z.CHENG,D.LIU,AUTH 2 H.SONGTITL STRUCTURAL BASIS FOR TRANSLATIONAL INHIBITION BY THE TUMOURTITL 2 SUPPRESSOR PDCD4REF EMBO J. V. 28 274 2009REFN ISSN 0261-4189PMID 19153607DOI 10.1038/EMBOJ.2008.278 Variant Set Distributions Mapped Variants
General Structure Information 2wtk STK11 structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex 2.65Å AUTH E.ZEQIRAJ,B.M.FILIPPI,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE LKB1-STRAD-MO25 COMPLEX REVEALS ANTITL 2 ALLOSTERIC MECHANISM OF KINASE ACTIVATION.REF SCIENCE V. 326 1707 2009REFN ISSN 0036-8075PMID 19892943DOI 10.1126/SCIENCE.1178377 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants