Assessment of Structural Intolerance and Durability
General Structure Information 3ixe LIMS2 structural basis of competition between pinch1 and pinch2 for binding to the ankyrin repeat domain of integrin-linked kinase 1.9Å AUTH B.P.CHISWELL,A.L.STIEGLER,Z.RAZINIA,E.NALIBOTSKI,AUTH 2 T.J.BOGGON,D.A.CALDERWOODTITL STRUCTURAL BASIS OF COMPETITION BETWEEN PINCH1 ANDTITL 2 PINCH2 FOR BINDING TO THE ANKYRIN REPEAT DOMAIN OFTITL 3 INTEGRIN-LINKED KINASE.REF J.STRUCT.BIOL. V. 170 157 2010REFN ISSN 1047-8477PMID […]
General Structure Information 3l11 RNF168 crystal structure of the ring domain of rnf168 2.12Å AUTH S.J.CAMPBELL,R.A.EDWARDS,C.C.LEUNG,D.NECULAI,C.D.HODGE,AUTH 2 S.DHE-PAGANON,J.N.GLOVERTITL MOLECULAR INSIGHTS INTO THE FUNCTION OF RING FINGERTITL 2 (RNF)-CONTAINING PROTEINS HRNF8 AND HRNF168 INTITL 3 UBC13/MMS2-DEPENDENT UBIQUITYLATION.REF J.BIOL.CHEM. V. 287 23900 2012REFN ISSN 0021-9258PMID 22589545DOI 10.1074/JBC.M112.359653 Variant Set Distributions Mapped Variants
General Structure Information 3iq7 GSG2 crystal structure of human haspin in complex with 5-iodotubercidin 2.0Å AUTH J.ESWARAN,D.PATNAIK,P.FILIPPAKOPOULOS,F.WANG,R.L.STEIN,AUTH 2 J.W.MURRAY,J.M.HIGGINS,S.KNAPPTITL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THE ATYPICALTITL 2 HUMAN KINASE HASPIN.REF PROC.NATL.ACAD.SCI.USA V. 106 20198 2009REFN ISSN 0027-8424PMID 19918057DOI 10.1073/PNAS.0901989106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jxx NFATC2IP nmr solution structure of ubiquitin-like domain of nfatc2ip. northeast structural genomics consortium target hr5627 -1.0Å AUTH R.S.DOHERTY,S.DHE-PAGANON,C.FARES,A.LEMAK,C.BUTLER,AUTH 2 S.SRISAILAM,M.KARRA,A.YEE,J.WEIGELT,A.M.EDWARDS,AUTH 3 C.H.ARROWSMITHTITL SOLUTION STRUCTURE OF UBIQUITIN-LIKE DOMAIN OFTITL 2 NFATC2IP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3lre KIF18A crystal structure analysis of human kinesin-8 motor domain 2.2Å AUTH C.PETERS,K.BREJC,L.BELMONT,A.J.BODEY,Y.LEE,M.YU,J.GUO,AUTH 2 R.SAKOWICZ,J.HARTMAN,C.A.MOORESTITL INSIGHT INTO THE MOLECULAR MECHANISM OF THE MULTITASKINGTITL 2 KINESIN-8 MOTOR.REF EMBO J. V. 29 3437 2010REFN ISSN 0261-4189PMID 20818331DOI 10.1038/EMBOJ.2010.220 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ljw PBRM1 crystal structure of the second bromodomain of human polybromo 1.5Å AUTH Z.CHARLOP-POWERS,L.ZENG,Q.ZHANG,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO SELECTIVE HISTONE H3 RECOGNITIONTITL 2 BY THE HUMAN POLYBROMO BROMODOMAIN 2.REF CELL RES. V. 20 529 2010REFN ISSN 1001-0602PMID 20368734DOI 10.1038/CR.2010.43 Variant Set Distributions Mapped Variants
General Structure Information 3hf1 RRM2B crystal structure of human p53r2 2.6Å AUTH P.SMITH,B.ZHOU,N.HO,Y.C.YUAN,L.SU,S.C.TSAI,Y.YENTITL 2.6 A X-RAY CRYSTAL STRUCTURE OF HUMAN P53R2, ATITL 2 P53-INDUCIBLE RIBONUCLEOTIDE REDUCTASE .REF BIOCHEMISTRY V. 48 11134 2009REFN ISSN 0006-2960PMID 19728742DOI 10.1021/BI9001425 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ndy APITD1 human mhf1-mhf2 dna complex 7.0Å AUTH Q.ZHAO,D.SARO,A.SACHPATZIDIS,T.R.SINGH,D.SCHLINGMAN,AUTH 2 X.F.ZHENG,A.MACK,M.S.TSAI,S.MOCHRIE,L.REGAN,A.R.MEETEI,AUTH 3 P.SUNG,Y.XIONGTITL THE MHF COMPLEX SENSES BRANCHED DNA BY BINDING A PAIR OFTITL 2 CROSSOVER DNA DUPLEXES.REF NAT COMMUN V. 5 2987 2014REFN ESSN 2041-1723PMID 24390579DOI 10.1038/NCOMMS3987 Variant Set Distributions Mapped Variants
General Structure Information 3ob9 MSL3 structure of the human msl3 chromo-barrel domain at 2.5 angstrom resolution 2.5Å AUTH S.A.MOORE,Y.FERHATOGLUTITL STRUCTURE OF THE HUMAN MSL3 CHROMO-BARREL DOMAIN AT 2.5TITL 2 ANGSTROM RESOLUTIONREF J.BIOL.CHEM. 2010REFN ESSN 1083-351X Variant Set Distributions Mapped Variants
General Structure Information 3cuq VPS36 integrated structural and functional model of the human escrt-ii complex 2.61Å AUTH Y.J.IM,J.H.HURLEYTITL INTEGRATED STRUCTURAL MODEL AND MEMBRANE TARGETING MECHANISMTITL 2 OF THE HUMAN ESCRT-II COMPLEXREF DEV.CELL V. 14 902 2008REFN ISSN 1534-5807PMID 18539118DOI 10.1016/J.DEVCEL.2008.04.004 Variant Set Distributions Mapped Variants