General Structure Information
| PDB ID | 3lre |
| HGNC Gene Label(s) | KIF18A |
| Structure Name | crystal structure analysis of human kinesin-8 motor domain |
| Resolution | 2.2Å |
| Reference | AUTH C.PETERS,K.BREJC,L.BELMONT,A.J.BODEY,Y.LEE,M.YU,J.GUO,AUTH 2 R.SAKOWICZ,J.HARTMAN,C.A.MOORESTITL INSIGHT INTO THE MOLECULAR MECHANISM OF THE MULTITASKINGTITL 2 KINESIN-8 MOTOR.REF EMBO J. V. 29 3437 2010REFN ISSN 0261-4189PMID 20818331DOI 10.1038/EMBOJ.2010.220 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 300 |
| Number Of SNVs | 69 |
| Number Of Permutations | 48689 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.041 |
| p-value | 0.928 |
COSMIC
| Number Of Residues | 300 |
| Number Of SNVs | 3 |
| Number Of Permutations | 171 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.333 |
| p-value | 0.086 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.326 |
| p-value | 0.586 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
