Assessment of Structural Intolerance and Durability
General Structure Information 2rep KIFC1 crystal structure of the motor domain of human kinesin family member c1 2.6Å AUTH H.ZHU,W.TEMPEL,H.HE,Y.SHEN,J.WANG,G.BROTHERS,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESINTITL 2 FAMILY MEMBER C1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wmn DOCK9 structure of the complex between dock9 and cdc42-gdp. 2.39Å AUTH J.YANG,Z.ZHANG,S.M.ROE,C.J.MARSHALL,D.BARFORDTITL ACTIVATION OF RHO GTPASES BY DOCK EXCHANGE FACTORSTITL 2 IS MEDIATED BY A NUCLEOTIDE SENSOR.REF SCIENCE V. 325 1398 2009REFN ISSN 0036-8075PMID 19745154DOI 10.1126/SCIENCE.1174468 Variant Set Distributions Mapped Variants
General Structure Information 2km6 NLRP7 nmr structure of the nlrp7 pyrin domain -1.0Å AUTH A.S.PINHEIRO,M.PROELL,C.EIBL,R.PAGE,R.SCHWARZENBACHER,W.PETITITL THREE-DIMENSIONAL STRUCTURE OF THE NLRP7 PYRIN DOMAIN:TITL 2 INSIGHT INTO PYRIN-PYRIN-MEDIATED EFFECTOR DOMAIN SIGNALINGTITL 3 IN INNATE IMMUNITY.REF J.BIOL.CHEM. V. 285 27402 2010REFN ISSN 0021-9258PMID 20547486DOI 10.1074/JBC.M110.113191 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1s18 CANT1 structure and protein design of human apyrase 1.7Å AUTH J.DAI,J.LIU,Y.DENG,T.M.SMITH,M.LUTITL STRUCTURE AND PROTEIN DESIGN OF A HUMAN PLATELETTITL 2 FUNCTION INHIBITOR.REF CELL(CAMBRIDGE,MASS.) V. 116 649 2004REFN ISSN 0092-8674PMID 15006348DOI 10.1016/S0092-8674(04)00172-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2w4r DHX58 crystal structure of the regulatory domain of human lgp2 2.6Å AUTH D.A.PIPPIG,J.C.HELLMUTH,S.CUI,A.KIRCHHOFER,AUTH 2 K.LAMMENS,A.LAMMENS,A.SCHMIDT,S.ROTHENFUSSER,AUTH 3 K.P.HOPFNERTITL THE REGULATORY DOMAIN OF THE RIG-I FAMILY ATPASETITL 2 LGP2 SENSES DOUBLE-STRANDED RNA.REF NUCLEIC ACIDS RES. V. 37 2014 2009REFN ISSN 0305-1048PMID 19208642DOI 10.1093/NAR/GKP059 Variant Set Distributions Mapped Variants
General Structure Information 3kvw DYRK2 crystal structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (dyrk2) in complex with an indirubin ligand 2.28Å AUTH P.FILIPPAKOPOULOS,V.MYRIANTHOPOULOS,M.KRITSANIDA,P.MAGIATIS,AUTH 2 A.L.SKALTSOUNIS,M.SOUNDARARAJAN,T.KROJER,O.GILEADI,E.HAPKA,AUTH 3 O.FEDOROV,G.BERRIDGE,J.WANG,L.SHRESTHA,M.VOLLMAR,AUTH 4 F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 5 E.MIKROS,S.KNAPPTITL CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINETITL 2 PHOSPHORYLATION REGULATED KINASE 2 (DYRK2) IN COMPLEX WITHTITL 3 AN INDIRUBIN LIGANDREF TO BE PUBLISHEDREFN Variant […]
General Structure Information 2v14 KIF16B kinesin 16b phox-homology domain (kif16b) 2.2Å AUTH N.R.BLATNER,M.I.WILSON,C.LEI,W.HONG,D.MURRAY,AUTH 2 R.L.WILLIAMS,W.CHOTITL THE STRUCTURAL BASIS OF NOVEL ENDOSOME ANCHORINGTITL 2 ACTIVITY OF KIF16B KINESIN.REF EMBO J. V. 26 3709 2007REFN ISSN 0261-4189PMID 17641687DOI 10.1038/SJ.EMBOJ.7601800 Variant Set Distributions Mapped Variants
General Structure Information 2rex RND1 crystal structure of the effector domain of plxnb1 bound with rnd1 gtpase 2.3Å AUTH Y.TONG,W.TEMPEL,L.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PLXNB1 BOUNDTITL 2 WITH RND1 GTPASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wjv UPF1 crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2 2.85Å AUTH M.CLERICI,A.MOURAO,I.GUTSCHE,N.H.GEHRING,M.W.HENTZE,AUTH 2 A.KULOZIK,J.KADLEC,M.SATTLER,S.CUSACKTITL UNUSUAL BIPARTITE MODE OF INTERACTION BETWEEN THETITL 2 NONSENSE-MEDIATED DECAY FACTORS, UPF1 AND UPF2.REF EMBO J. V. 28 2293 2009REFN ISSN 0261-4189PMID 19556969DOI 10.1038/EMBOJ.2009.175 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3lcy TTN titin ig tandem domains a164-a165 2.5Å AUTH Q.CHEN,M.WILMANNSTITL STRUCTURAL INVESTIGATION OF THE TITIN A-BAND TANDEM IGTITL 2 DOMAINS A164-A165REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants