General Structure Information
| PDB ID | 1s18 |
| HGNC Gene Label(s) | CANT1 |
| Structure Name | structure and protein design of human apyrase |
| Resolution | 1.7Å |
| Reference | AUTH J.DAI,J.LIU,Y.DENG,T.M.SMITH,M.LUTITL STRUCTURE AND PROTEIN DESIGN OF A HUMAN PLATELETTITL 2 FUNCTION INHIBITOR.REF CELL(CAMBRIDGE,MASS.) V. 116 649 2004REFN ISSN 0092-8674PMID 15006348DOI 10.1016/S0092-8674(04)00172-2 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 317 |
| Number Of SNVs | 97 |
| Number Of Permutations | 33048 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.046 |
| p-value | 0.704 |
ClinVar
| Number Of Residues | 317 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1058 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.2 |
| p-value | 0.042 |
COSMIC
| Number Of Residues | 317 |
| Number Of SNVs | 7 |
| Number Of Permutations | 4388 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.286 |
| p-value | 0.761 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 97 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.176 |
| p-value | 0.058 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 97 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.171 |
| p-value | 0.498 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
