Assessment of Structural Intolerance and Durability
General Structure Information 3le4 DGCR8 crystal structure of the dgcr8 dimerization domain 1.7Å AUTH R.SENTURIA,M.FALLER,S.YIN,J.A.LOO,D.CASCIO,M.R.SAWAYA,AUTH 2 D.HWANG,R.T.CLUBB,F.GUOTITL STRUCTURE OF THE DIMERIZATION DOMAIN OF DIGEORGE CRITICALTITL 2 REGION 8REF PROTEIN SCI. V. 19 1354 2010REFN ISSN 0961-8368PMID 20506313DOI 10.1002/PRO.414 Variant Set Distributions Mapped Variants
General Structure Information 3i4r NUP133 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1l2j ESR2 human estrogen receptor beta ligand-binding domain in complex with (r, r)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol 2.95Å AUTH A.K.SHIAU,D.BARSTAD,J.T.RADEK,M.J.MEYERS,K.W.NETTLES,AUTH 2 B.S.KATZENELLENBOGEN,J.A.KATZENELLENBOGEN,D.A.AGARD,AUTH 3 G.L.GREENETITL STRUCTURAL CHARACTERIZATION OF A SUBTYPE-SELECTIVE LIGANDTITL 2 REVEALS A NOVEL MODE OF ESTROGEN RECEPTOR ANTAGONISM.REF NAT.STRUCT.BIOL. V. 9 359 2002REFN ISSN 1072-8368PMID 11953755 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1wxp THOC1 solution structure of the death domain of nuclear matrix protein p84 -1.0Å AUTH T.N.NIRAULA,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE DEATH DOMAIN OF NUCLEARTITL 2 MATRIX PROTEIN P84REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2izv SOCS4 crystal structure of socs-4 in complex with elongin-b and elongin-c at 2.55a resolution 2.55Å AUTH A.N.BULLOCK,M.C.RODRIGUEZ,J.E.DEBRECZENI,Z.SONGYANG,S.KNAPPTITL STRUCTURE OF THE SOCS4-ELONGINB/C COMPLEX REVEALS ATITL 2 DISTINCT SOCS BOX INTERFACE AND THE MOLECULAR BASIS FORTITL 3 SOCS-DEPENDENT EGFR DEGRADATION.REF STRUCTURE V. 15 1493 2007REFN ISSN 0969-2126PMID 17997974DOI 10.1016/J.STR.2007.09.016 Variant Set Distributions Mapped […]
General Structure Information 2xdv MINA crystal structure of the catalytic domain of flj14393 2.57Å AUTH R.CHOWDHURY,R.SEKIRNIK,N.C.BRISSETT,T.KROJER,C.-H.HO,S.S.NG,AUTH 2 I.J.CLIFTON,W.GE,N.J.KERSHAW,G.C.FOX,J.R.C.MUNIZ,M.VOLLMAR,AUTH 3 C.PHILLIPS,E.S.PILKA,K.L.KAVANAGH,F.VON DELFT,U.OPPERMANN ,AUTH 4 M.A.MCDONOUGH,A.J.DOHERTY,C.J.SCHOFIELDTITL RIBOSOMAL OXYGENASES ARE STRUCTURALLY CONSERVED FROMTITL 2 PROKARYOTES TO HUMANSREF NATURE V. 510 422 2014REFN ISSN 0028-0836PMID 24814345DOI 10.1038/NATURE13263 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2w18 PALB2 crystal structure of the c-terminal wd40 domain of human palb2 1.9Å AUTH A.W.OLIVER,S.SWIFT,C.J.LORD,A.ASHWORTH,L.H.PEARLTITL STRUCTURAL BASIS FOR RECRUITMENT OF BRCA2 BY PALB2REF EMBO REP. V. 10 990 2009REFN ISSN 1469-221XPMID 19609323DOI 10.1038/EMBOR.2009.126 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3iq7 GSG2 crystal structure of human haspin in complex with 5-iodotubercidin 2.0Å AUTH J.ESWARAN,D.PATNAIK,P.FILIPPAKOPOULOS,F.WANG,R.L.STEIN,AUTH 2 J.W.MURRAY,J.M.HIGGINS,S.KNAPPTITL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THE ATYPICALTITL 2 HUMAN KINASE HASPIN.REF PROC.NATL.ACAD.SCI.USA V. 106 20198 2009REFN ISSN 0027-8424PMID 19918057DOI 10.1073/PNAS.0901989106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ulh ALYREF crystal structure of a rna binding domain of tho complex subunit 4 protein (thoc4) from homo sapiens at 2.54 a resolution 2.54Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A RNA BINDING DOMAIN OF THO COMPLEXTITL 2 SUBUNIT 4 PROTEIN (THOC4) […]
General Structure Information 2jxx NFATC2IP nmr solution structure of ubiquitin-like domain of nfatc2ip. northeast structural genomics consortium target hr5627 -1.0Å AUTH R.S.DOHERTY,S.DHE-PAGANON,C.FARES,A.LEMAK,C.BUTLER,AUTH 2 S.SRISAILAM,M.KARRA,A.YEE,J.WEIGELT,A.M.EDWARDS,AUTH 3 C.H.ARROWSMITHTITL SOLUTION STRUCTURE OF UBIQUITIN-LIKE DOMAIN OFTITL 2 NFATC2IP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants