Assessment of Structural Intolerance and Durability
General Structure Information 1v95 NCOA5 solution structure of anticodon binding domain from nuclear receptor coactivator 5 (human kiaa1637 protein) -1.0Å AUTH C.ZHAO,T.KIGAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF ANTICODON BINDING DOMAINTITL 2 FROM NUCLEAR RECEPTOR COACTIVATOR 5 (HUMANTITL 3 KIAA1637 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1x5w ZFP64 solution structure of the c2h2 type zinc-binding domain of human zinc finger protein 64, isoforms 1 and 2 -1.0Å AUTH M.YONEYAMA,S.KOSHIBA,N.TOCHIO,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC-BINDINGTITL 2 DOMAIN OF HUMAN ZINC FINGER PROTEIN 64, ISOFORMS 1TITL 3 AND 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]
General Structure Information 2dmd ZFP64 solution structure of the n-terminal c2h2 type zinc-binding domain of the zinc finger protein 64, isoforms 1 and 2 -1.0Å AUTH M.YONEYAMA,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL C2H2 TYPETITL 2 ZINC-BINDING DOMAIN OF THE ZINC FINGER PROTEIN 64,TITL 3 ISOFORMS 1 AND 2REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2ed0 ABI2 solution structure of the sh3 domain of abl interactor 2 (abelson interactor 2) -1.0Å AUTH H.ABE,N.TOCHIO,K.MIYAMOTO,K.SAITO,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF ABLTITL 2 INTERACTOR 2 (ABELSON INTERACTOR 2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2khx DROSHA drosha double-stranded rna binding motif -1.0Å AUTH G.A.MUELLER,M.T.MILLER,E.F.DEROSE,M.GHOSH,R.E.LONDON,AUTH 2 T.M.HALLTITL SOLUTION STRUCTURE OF THE DROSHA DOUBLE-STRANDED RNA-BINDINGTITL 2 DOMAIN.REF SILENCE V. 1 2 2010REFN ESSN 1758-907XPMID 20226070DOI 10.1186/1758-907X-1-2 Variant Set Distributions Mapped Variants
General Structure Information 2xc7 PHAX solution structure of phax-rbd in complex with ssrna -1.0Å AUTH A.MOURAO,A.VARROT,C.D.MACKERETH,S.CUSACK,M.SATTLERTITL STRUCTURE AND RNA RECOGNITION BY THE SNRNA ANDTITL 2 SNORNA TRANSPORT FACTOR PHAX.REF RNA V. 16 1205 2010REFN ISSN 1355-8382PMID 20430857DOI 10.1261/RNA.2009910 Variant Set Distributions Mapped Variants
General Structure Information 2x6u TBX5 crystal structure of human tbx5 in the dna-free form 1.9Å AUTH C.U.STIRNIMANN,D.PTCHELKINE,C.GRIMM,C.W.MULLERTITL STRUCTURAL BASIS OF TBX5-DNA RECOGNITION: THE T-TITL 2 BOX DOMAIN IN ITS DNA-BOUND AND -UNBOUND FORM.REF J.MOL.BIOL. V. 400 71 2010REFN ISSN 0022-2836PMID 20450920DOI 10.1016/J.JMB.2010.04.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3omk NR1H4 crystal structure of human fxr in complex with (2s)-2-[2-(4- chlorophenyl)-5,6-difluoro-1h-benzimidazol-1-yl]-2-cyclohexyl-n-(2- methylphenyl)ethanamide 1.9Å AUTH H.G.F.RICHTER,G.M.BENSON,K.H.BLEICHER,D.BLUM,E.CHAPUT,AUTH 2 N.CLEMANN,S.FENG,C.GARDES,U.GRETHER,P.HARTMAN,B.KUHN,AUTH 3 R.E.MARTIN,J.M.PLANCHER,M.G.RUDOLPH,F.SCHULER,S.TAYLORTITL OPTIMIZATION OF A NOVEL CLASS OF BENZIMIDAZOLE-BASEDTITL 2 FARNESOID X RECEPTOR (FXR) AGONISTS TO IMPROVETITL 3 PHYSICOCHEMICAL AND ADME PROPERTIESREF BIOORG.MED.CHEM.LETT. V. 21 1134 2011REFN ISSN 0960-894XPMID 21269824DOI 10.1016/J.BMCL.2010.12.123 Variant Set Distributions […]
General Structure Information 1wbp SRPK1 srpk1 bound to 9mer docking motif peptide 2.4Å AUTH J.C.NGO,S.CHAKRABARTI,J.-H.DING,A.VELAZQUEZ-DONES,AUTH 2 B.NOLEN,B.E.AUBOL,J.A.ADAMS,X.-D.FU,G.GHOSHTITL INTERPLAY BETWEEN SRPK AND CLK/STY KINASES INTITL 2 PHOSPHORYLATION OF THE SPLICING FACTOR ASF/SF2 ISTITL 3 REGULATED BY A DOCKING MOTIF IN ASF/SF2REF MOL.CELL V. 20 77 2005REFN ISSN 1097-2765PMID 16209947DOI 10.1016/J.MOLCEL.2005.08.025 Variant Set Distributions Mapped Variants
General Structure Information 4fq3 TNPO1 crystal structure of transportin/fus-nls 3.0Å AUTH W.GONG,C.NIU,M.JIA,F.GAOTITL CRYSTAL STRUCTURE OF TRANSPORTIN/FUS-NLSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants