Assessment of Structural Intolerance and Durability
General Structure Information 2r3v MVK the biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism 2.5Å AUTH Z.FU,N.E.VOYNOVA,T.J.HERDENDORF,H.M.MIZIORKO,AUTH 2 J.J.KIMTITL BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACKTITL 2 INHIBITION OF MEVALONATE KINASE AND ISOPRENOIDTITL 3 METABOLISM.REF BIOCHEMISTRY V. 47 3715 2008REFN ISSN 0006-2960PMID 18302342DOI 10.1021/BI7024386 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2r3v MVK the biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism 2.5Å AUTH Z.FU,N.E.VOYNOVA,T.J.HERDENDORF,H.M.MIZIORKO,AUTH 2 J.J.KIMTITL BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACKTITL 2 INHIBITION OF MEVALONATE KINASE AND ISOPRENOIDTITL 3 METABOLISM.REF BIOCHEMISTRY V. 47 3715 2008REFN ISSN 0006-2960PMID 18302342DOI 10.1021/BI7024386 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2r3v MVK the biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism 2.5Å AUTH Z.FU,N.E.VOYNOVA,T.J.HERDENDORF,H.M.MIZIORKO,AUTH 2 J.J.KIMTITL BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACKTITL 2 INHIBITION OF MEVALONATE KINASE AND ISOPRENOIDTITL 3 METABOLISM.REF BIOCHEMISTRY V. 47 3715 2008REFN ISSN 0006-2960PMID 18302342DOI 10.1021/BI7024386 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2vze ACSM2A crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in complex with amp 2.45Å AUTH G.KOCHAN,E.S.PILKA,F.V.DELFT,U.OPPERMANN,W.W.YUETITL STRUCTURAL SNAPSHOTS FOR THE CONFORMATION- DEPENDENTTITL 2 CATALYSIS BY HUMAN MEDIUM-CHAIN ACYL- COENZYME A SYNTHETASETITL 3 ACSM2A.REF J.MOL.BIOL. V. 388 997 2009REFN ISSN 0022-2836PMID 19345228DOI 10.1016/J.JMB.2009.03.064 Variant Set Distributions Ripley’s K […]
General Structure Information 4azm FABP5 human epidermal fatty acid-binding protein (fabp5) in complex with the inhibitor bms-309413 2.75Å AUTH B.SANSON,T.WANG,J.SUN,L.WANG,M.KACZOCHA,I.OJIMA,D.DEUTSCH,AUTH 2 H.LITITL CRYSTALLOGRAPHIC STUDY OF FABP5 AS AN INTRACELLULARTITL 2 ENDOCANNABINOID TRANSPORTER.REF ACTA CRYSTALLOGR.,SECT.D V. 70 290 2014REFN ISSN 0907-4449PMID 24531463DOI 10.1107/S1399004713026795 Variant Set Distributions Mapped Variants
General Structure Information 3d59 PLA2G7 crystal structure of human plasma platelet activating factor acetylhydrolase 1.5Å AUTH U.SAMANTA,B.J.BAHNSONTITL CRYSTAL STRUCTURE OF HUMAN PLASMATITL 2 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE:TITL 3 STRUCTURAL IMPLICATION TO LIPOPROTEIN BINDING ANDTITL 4 CATALYSIS.REF J.BIOL.CHEM. V. 283 31617 2008REFN ISSN 0021-9258PMID 18784071DOI 10.1074/JBC.M804750200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3f3y SULT2A1 crystal structure of human cytosolic sulfotransferase sult2a1 in complex with pap and lithocholic acid 2.2Å AUTH P.W.PAN,A.DONG,M.AMAYA,A.M.EDWARDSTITL RYSTAL STRUCTURE OF HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASE SULT2A1 IN COMPLEX WITH PAP ANDTITL 3 LITHOCHOLIC ACIDREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2m0p LRP2 solution structure of the tenth complement type repeat of human megalin -1.0Å AUTH R.DAGIL,C.OSHEA,A.NYKJAR,A.M.BONVIN,B.B.KRAGELUNDTITL GENTAMICIN BINDS TO THE MEGALIN RECEPTOR AS A COMPETITIVETITL 2 INHIBITOR USING THE COMMON LIGAND BINDING MOTIF OFTITL 3 COMPLEMENT TYPE REPEATS: INSIGHT FROM THE NMR STRUCTURE OFTITL 4 THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE […]
General Structure Information 4cc1 JAG1 notch ligand, jagged-1, contains an n-terminal c2 domain 2.84Å AUTH C.R.CHILAKURI,D.SHEPPARD,M.X.G.ILAGAN,L.R.HOLT,F.ABBOTT,AUTH 2 S.LIANG,R.KOPAN,P.A.HANDFORD,S.M.LEATITL STRUCTURAL ANALYSIS UNCOVERS LIPID-BINDING PROPERTIES OFTITL 2 NOTCH LIGANDSREF CELL REP. V. 5 861 2013REFN ISSN 2211-1247PMID 24239355DOI 10.1016/J.CELREP.2013.10.029 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3d9s AQP5 human aquaporin 5 (aqp5) – high resolution x-ray structure 2.0Å AUTH R.HORSEFIELD,K.NORDEN,M.FELLERT,A.BACKMARK,AUTH 2 S.TORNROTH-HORSEFIELD,AUTH 3 A.C.TERWISSCHA VAN SCHELTINGA,J.KVASSMAN,AUTH 4 P.KJELLBOM,U.JOHANSON,R.NEUTZETITL HIGH-RESOLUTION X-RAY STRUCTURE OF HUMAN AQUAPORINTITL 2 5REF PROC.NATL.ACAD.SCI.USA V. 105 13327 2008REFN ISSN 0027-8424PMID 18768791DOI 10.1073/PNAS.0801466105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]