Assessment of Structural Intolerance and Durability
General Structure Information 4g8a LY96 crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps 2.4Å AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4hhv COL4A3BP crystal structure of ceramide transfer protein pleckstrin homology domain 1.75Å AUTH J.PRASHEK,T.TRUONG,X.YAOTITL CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM THETITL 2 CERAMIDE TRANSFER PROTEIN: IMPLICATIONS FOR CONFORMATIONALTITL 3 CHANGE UPON LIGAND BINDING.REF PLOS ONE V. 8 79590 2013REFN ESSN 1932-6203PMID 24260258DOI 10.1371/JOURNAL.PONE.0079590 Variant Set Distributions Mapped Variants
General Structure Information 2h80 STARD13 nmr structures of sam domain of deleted in liver cancer 2 (dlc2) -1.0Å AUTH H.LI,K.L.FUNG,D.Y.JIN,S.S.CHUNG,Y.P.CHING,I.O.NG,AUTH 2 K.H.SZE,B.C.KO,H.SUNTITL SOLUTION STRUCTURES, DYNAMICS, AND LIPID-BINDINGTITL 2 OF THE STERILE ALPHA-MOTIF DOMAIN OF THE DELETEDTITL 3 IN LIVER CANCER 2REF PROTEINS V. 67 1154 2007REFN ISSN 0887-3585PMID 17380510DOI 10.1002/PROT.21361 Variant Set Distributions Mapped Variants
General Structure Information 3h3s COL4A3BP crystal structure of the cert start domain in complex with hpa-15 1.66Å AUTH N.KUDO,K.KUMAGAI,R.MATSUBARA,S.KOBAYASHI,K.HANADA,AUTH 2 S.WAKATSUKI,R.KATOTITL CRYSTAL STRUCTURES OF THE CERT START DOMAIN WITHTITL 2 INHIBITORS PROVIDE INSIGHTS INTO THE MECHANISM OFTITL 3 CERAMIDE TRANSFER.REF J.MOL.BIOL. V. 396 245 2010REFN ISSN 0022-2836PMID 20036255DOI 10.1016/J.JMB.2009.12.029 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3mdv CYP46A1 clotrimazole complex of cytochrome p450 46a1 2.4Å AUTH N.MAST,C.CHARVET,I.A.PIKULEVA,C.D.STOUTTITL STRUCTURAL BASIS OF DRUG BINDING TO CYP46A1, AN ENZYME THATTITL 2 CONTROLS CHOLESTEROL TURNOVER IN THE BRAIN.REF J.BIOL.CHEM. V. 285 31783 2010REFN ISSN 0021-9258PMID 20667828DOI 10.1074/JBC.M110.143313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pso STARD13 human stard13 (dlc2) lipid transfer and protein localization domain 2.8Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Mapped Variants
General Structure Information 3rzn GLTP crystal structure of human glycolipid transfer protein complexed with 3-o-sulfo-galactosylceramide containing nervonoyl acyl chain (24:1) 1.1Å AUTH V.R.SAMYGINA,A.N.POPOV,A.CABO-BILBAO,B.OCHOA-LIZARRALDE,AUTH 2 F.GONI-DE-CERIO,X.ZHAI,J.G.MOLOTKOVSKY,D.J.PATEL,R.E.BROWN,AUTH 3 L.MALININATITL ENHANCED SELECTIVITY FOR SULFATIDE BY ENGINEERED HUMANTITL 2 GLYCOLIPID TRANSFER PROTEIN.REF STRUCTURE V. 19 1644 2011REFN ISSN 0969-2126PMID 22078563DOI 10.1016/J.STR.2011.09.011 Variant Set Distributions Mapped Variants
General Structure Information 3ose MARK1 structure of the kinase associated domain 1 (ka1) from mark1 kinase 1.7Å AUTH K.MORAVCEVIC,J.M.MENDROLA,K.R.SCHMITZ,Y.H.WANG,D.SLOCHOWER,AUTH 2 P.A.JANMEY,M.A.LEMMONTITL KINASE ASSOCIATED-1 DOMAINS DRIVE MARK/PAR1 KINASES TOTITL 2 MEMBRANE TARGETS BY BINDING ACIDIC PHOSPHOLIPIDS.REF CELL(CAMBRIDGE,MASS.) V. 143 966 2010REFN ISSN 0092-8674PMID 21145462DOI 10.1016/J.CELL.2010.11.028 Variant Set Distributions Mapped Variants
General Structure Information 2dmh MYOF solution structure of the first c2 domain of human myoferlin -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2 DOMAIN OF HUMANTITL 2 MYOFERLINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1ln3 PCTP structure of human phosphatidylcholine transfer protein in complex with palmitoyl-linoleoyl phosphatidylcholine (seleno-met protein) 2.9Å AUTH S.L.RODERICK,W.W.CHAN,D.S.AGATE,L.R.OLSEN,AUTH 2 M.W.VETTING,K.R.RAJASHANKAR,D.E.COHENTITL STRUCTURE OF HUMAN PHOSPHATIDYLCHOLINE TRANSFERTITL 2 PROTEIN IN COMPLEX WITH ITS LIGAND.REF NAT.STRUCT.BIOL. V. 9 507 2002REFN ISSN 1072-8368PMID 12055623 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]