Assessment of Structural Intolerance and Durability
General Structure Information 2q4g RNH1 ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i 1.95Å AUTH R.J.JOHNSON,J.G.MCCOY,C.A.BINGMAN,G.N.PHILLIPS JR.,AUTH 2 R.T.RAINESTITL INHIBITION OF HUMAN PANCREATIC RIBONUCLEASE BY THE HUMANTITL 2 RIBONUCLEASE INHIBITOR PROTEIN.REF J.MOL.BIOL. V. 368 434 2007REFN ISSN 0022-2836PMID 17350650DOI 10.1016/J.JMB.2007.02.005 Variant Set Distributions Mapped Variants
General Structure Information 2uzx MET structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i 2.8Å AUTH H.H.NIEMANN,V.JAGER,P.J.G.BUTLER,J.VAN DEN HEUVEL,AUTH 2 S.SCHMIDT,D.FERRARIS,E.GHERARDI,D.W.HEINZTITL STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASETITL 2 MET IN COMPLEX WITH THE LISTERIA INVASION PROTEINTITL 3 INLBREF CELL(CAMBRIDGE,MASS.) V. 130 235 2007REFN […]
General Structure Information 4glp CD14 the crystal structure of soluble human cd14 reveals a bent solenoid with a hydrophobic amino-terminal pocket. 4.0Å AUTH S.L.KELLEY,T.LUKK,S.K.NAIR,R.I.TAPPINGTITL THE CRYSTAL STRUCTURE OF HUMAN SOLUBLE CD14 REVEALS A BENTTITL 2 SOLENOID WITH A HYDROPHOBIC AMINO-TERMINAL POCKET.REF J.IMMUNOL. V. 190 1304 2013REFN ISSN 0022-1767PMID 23264655DOI 10.4049/JIMMUNOL.1202446 Variant Set Distributions Ripley’s K […]
General Structure Information 2v70 SLIT2 third lrr domain of human slit2 3.01Å AUTH C.MORLOT,W.HEMRIKA,R.A.ROMIJN,P.GROS,S.CUSACK,A.A.MCCARTHYTITL PRODUCTION OF SLIT2 LRR DOMAINS IN MAMMALIAN CELLS FORTITL 2 STRUCTURAL STUDIES AND THE STRUCTURE OF HUMAN SLIT2 DOMAINTITL 3 3.REF ACTA CRYSTALLOGR.,SECT.D V. 63 961 2007REFN ISSN 0907-4449PMID 17704564DOI 10.1107/S0907444907035470 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2wfh SLIT2 the human slit 2 dimerization domain d4 1.8Å AUTH E.SEIRADAKE,A.C.VON PHILIPSBORN,M.HENRY,M.FRITZ,AUTH 2 H.LORTAT-JACOB,M.JAMIN,W.HEMRIKA,M.BASTMEYER,S.CUSACK,AUTH 3 A.A.MCCARTHYTITL STRUCTURE AND FUNCTIONAL RELEVANCE OF THE SLIT2TITL 2 HOMODIMERIZATION DOMAIN.REF EMBO REP. V. 10 736 2009REFN ISSN 1469-221XPMID 19498462DOI 10.1038/EMBOR.2009.95 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2z7x TLR2 crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide 2.1Å AUTH M.S.JIN,S.E.KIM,J.Y.HEO,M.E.LEE,H.M.KIM,S.G.PAIK,H.LEE,AUTH 2 J.O.LEETITL CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BYTITL 2 BINDING OF A TRI-ACYLATED LIPOPEPTIDEREF CELL(CAMBRIDGE,MASS.) V. 130 1071 2007REFN ISSN 0092-8674PMID 17889651DOI 10.1016/J.CELL.2007.09.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4kng LGR5 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants