Assessment of Structural Intolerance and Durability
General Structure Information 1×67 DBNL solution structure of the cofilin homology domain of hip-55 (drebrin-like protein) -1.0Å AUTH A.K.GORONCY,S.KOSHIBA,N.TOCHIO,T.TOMIZAWA,M.SATO,AUTH 2 M.INOUE,S.WATANABE,Y.HAYASHIZAKI,A.TANAKA,T.KIGAWA,AUTH 3 S.YOKOYAMATITL NMR SOLUTION STRUCTURES OF ACTIN DEPOLYMERIZINGTITL 2 FACTOR HOMOLOGY DOMAINS.REF PROTEIN SCI. V. 18 2384 2009REFN ISSN 0961-8368PMID 19768801DOI 10.1002/PRO.248 Variant Set Distributions Mapped Variants
General Structure Information 2hak MARK1 catalytic and ubiqutin-associated domains of mark1/par-1 2.6Å AUTH A.MARX,C.NUGOOR,J.MUELLER,S.PANNEERSELVAM,T.TIMM,AUTH 2 M.BILANG,E.MYLONAS,D.I.SVERGUN,E.-M.MANDELKOW,AUTH 3 E.MANDELKOWTITL STRUCTURAL VARIATIONS IN THE CATALYTIC ANDTITL 2 UBIQUITIN-ASSOCIATED DOMAINS OFTITL 3 MICROTUBULE-ASSOCIATED PROTEIN/MICROTUBULETITL 4 AFFINITY REGULATING KINASE (MARK) 1 AND MARK2REF J.BIOL.CHEM. V. 281 27586 2006REFN ISSN 0021-9258PMID 16803889DOI 10.1074/JBC.M604865200 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3vro CBLC crystal structure of the tyrosine kinase binding domain of cbl-c in complex with phospho-src peptide 1.8Å AUTH K.TAKESHITA,T.TEZUKA,Y.ISOZAKI,E.YAMASHITA,M.SUZUKI,M.KIM,AUTH 2 Y.YAMANASHI,T.YAMAMOTO,A.NAKAGAWATITL STRUCTURAL FLEXIBILITY REGULATES PHOSPHOPEPTIDE-BINDINGTITL 2 ACTIVITY OF THE TYROSINE KINASE BINDING DOMAIN OF CBL-C.REF J.BIOCHEM. V. 152 487 2012REFN ISSN 0021-924XPMID 22888118DOI 10.1093/JB/MVS085 Variant Set Distributions Mapped Variants
General Structure Information 2f57 PAK7 crystal structure of the human p21-activated kinase 5 1.8Å AUTH J.ESWARAN,W.H.LEE,J.E.DEBRECZENI,P.FILIPPAKOPOULOS,AUTH 2 A.TURNBULL,O.FEDOROV,S.W.DEACON,J.R.PETERSON,S.KNAPPTITL CRYSTAL STRUCTURES OF THE P21-ACTIVATED KINASES PAK4, PAK5,TITL 2 AND PAK6 REVEAL CATALYTIC DOMAIN PLASTICITY OF ACTIVE GROUPTITL 3 II PAKS.REF STRUCTURE V. 15 201 2007REFN ISSN 0969-2126PMID 17292838DOI 10.1016/J.STR.2007.01.001 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4fnw ALK crystal structure of the apo f1174l anaplastic lymphoma kinase catalytic domain 1.75Å AUTH L.F.EPSTEIN,H.CHEN,R.EMKEY,D.A.WHITTINGTONTITL THE R1275Q NEUROBLASTOMA MUTANT AND CERTAIN ATP-COMPETITIVETITL 2 INHIBITORS STABILIZE ALTERNATIVE ACTIVATION LOOPTITL 3 CONFORMATIONS OF ANAPLASTIC LYMPHOMA KINASE.REF J.BIOL.CHEM. V. 287 37447 2012REFN ISSN 0021-9258PMID 22932897DOI 10.1074/JBC.M112.391425 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4f9b DBF4 human cdc7 kinase in complex with dbf4 and pha767491 2.5Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Mapped Variants
General Structure Information 2x7f TNIK crystal structure of the kinase domain of human traf2- and nck-interacting kinase with wee1chk1 inhibitor 2.8Å AUTH M.VOLLMAR,I.ALFANO,B.SHRESTHA,J.BRAY,J.R.C.MUNIZ,A.ROOS,AUTH 2 P.FILIPPAKOPOULOS,N.BURGESS-BROWN,E.UGOCHUKWU,O.GILEADI,AUTH 3 C.PHILLIPS,P.MAHAJAN,A.C.W.PIKE,O.FEDOROV,A.CHAIKUAD,AUTH 4 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 5 S.KNAPPTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- ANDTITL 2 NCK-INTERACTING KINASE WITH WEE1CHK1 INHIBITORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]
General Structure Information 1wmk DAPK2 human death-associated kinase drp-1, mutant s308d d40 3.6Å AUTH P.KURSULA,G.SHANI,A.KIMCHI,M.WILMANNSTITL STRUCTURE OF THE INHIBITED CONFORMATION OF DRP-1TITL 2 KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ks7 PAK6 pak6 kinase domain in complex with pf-3758309 1.4Å AUTH J.GAO,B.H.HA,H.J.LOU,E.M.MORSE,R.ZHANG,D.A.CALDERWOOD,AUTH 2 B.E.TURK,T.J.BOGGONTITL SUBSTRATE AND INHIBITOR SPECIFICITY OF THE TYPE IITITL 2 P21-ACTIVATED KINASE, PAK6.REF PLOS ONE V. 8 77818 2013REFN ESSN 1932-6203PMID 24204982DOI 10.1371/JOURNAL.PONE.0077818 Variant Set Distributions Mapped Variants
General Structure Information 2jfl SLK crystal structure of human ste20-like kinase ( diphosphorylated form) bound to 5- amino-3-((4-( aminosulfonyl)phenyl)amino)-n-(2,6- difluorophenyl)-1h-1,2, 4-triazole-1-carbothioamide 2.2Å AUTH A.C.W.PIKE,P.RELLOS,F.H.NIESEN,A.TURNBULL,A.W.OLIVER,AUTH 2 S.A.PARKER,B.E.TURK,L.H.PEARL,S.KNAPPTITL ACTIVATION SEGMENT DIMERIZATION: A MECHANISM FOR KINASETITL 2 AUTOPHOSPHORYLATION OF NON-CONSENSUS SITES.REF EMBO J. V. 27 704 2008REFN ISSN 0261-4189PMID 18239682DOI 10.1038/EMBOJ.2008.8 Variant Set Distributions Mapped Variants