Assessment of Structural Intolerance and Durability
General Structure Information 3a7h STK24 human mst3 kinase in complex with atp 1.96Å AUTH T.P.KO,W.Y.JENG,C.I.LIU,M.D.LAI,C.L.WU,W.J.CHANG,H.L.SHR,AUTH 2 T.J.LU,A.H.J.WANGTITL STRUCTURES OF HUMAN MST3 KINASE IN COMPLEX WITH ADENINE, ADPTITL 2 AND MN2+.REF ACTA CRYSTALLOGR.,SECT.D V. 66 145 2010REFN ISSN 0907-4449PMID 20124694DOI 10.1107/S0907444909047507 Variant Set Distributions Mapped Variants
General Structure Information 2×18 AKT3 the crystal structure of the ph domain of human akt3 protein kinase 1.46Å AUTH M.VOLLMAR,J.WANG,Y.ZHANG,J.M.ELKINS,N.BURGESS-BROWN,AUTH 2 A.CHAIKUAD,A.C.W.PIKE,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,S.KNAPPTITL THE CRYSTAL STRUCTURE OF THE PH DOMAIN OF HUMAN AKT3TITL 2 PROTEIN KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ch6 NAGK crystal structure of human n-acetylglucosamine kinase in complex with adp and glucose 2.72Å AUTH W.A.WEIHOFEN,M.BERGER,H.CHEN,W.SAENGER,S.HINDERLICHTITL STRUCTURES OF HUMAN N-ACETYLGLUCOSAMINE KINASE IN TWOTITL 2 COMPLEXES WITH N-ACETYLGLUCOSAMINE AND WITH ADP/GLUCOSE:TITL 3 INSIGHTS INTO SUBSTRATE SPECIFICITY AND REGULATION.REF J.MOL.BIOL. V. 364 388 2006REFN ISSN 0022-2836PMID 17010375DOI 10.1016/J.JMB.2006.08.085 Variant Set Distributions Ripley’s K […]
General Structure Information 4i6h PLK2 selective & brain-permeable polo-like kinase-2 (plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain 1.91Å AUTH D.L.AUBELE,R.K.HOM,M.ADLER,R.A.GALEMMO,S.BOWERS,A.P.TRUONG,AUTH 2 H.PAN,P.BEROZA,R.J.NEITZ,N.YAO,M.LIN,G.TONN,H.ZHANG,AUTH 3 M.P.BOVA,Z.REN,D.TAM,L.RUSLIM,J.BAKER,L.DIEP,K.FITZGERALD,AUTH 4 J.HOFFMAN,R.MOTTER,D.FAUSS,P.TANAKA,M.DAPPEN,J.JAGODZINSKI,AUTH 5 W.CHAN,A.W.KONRADI,L.LATIMER,Y.L.ZHU,H.L.SHAM,J.P.ANDERSON,AUTH 6 M.BERGERON,D.R.ARTISTITL SELECTIVE & BRAIN-PERMEABLE POLO-LIKE KINASE-2 (PLK-2)TITL 2 INHIBITORS THAT REDUCE ALPHA-SYNUCLEIN PHOSPHORYLATION INTITL 3 RAT BRAINREF CHEMMEDCHEM V. 8 1295 2013REFN ISSN 1860-7179PMID […]
General Structure Information 2el8 STAP2 solution structure of the human stap2 sh2 domain -1.0Å AUTH T.KASAI,K.MIYAMOTO,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,AUTH 2 S.WATANABE,T.HARADA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN STAP2 SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2iwi PIM2 crystal structure of the human pim2 in complex with a ruthenium organometallic ligand ru1 2.8Å AUTH A.N.BULLOCK,S.RUSSO,A.AMOS,N.PAGANO,H.BREGMAN,AUTH 2 J.E.DEBRECZENI,W.H.LEE,F.VON DELFT,E.MEGGERS,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF THE PIM2 KINASE IN COMPLEXTITL 2 WITH AN ORGANORUTHENIUM INHIBITOR.REF PLOS ONE V. 4 E7112 2009REFN ISSN 1932-6203PMID 19841674DOI 10.1371/JOURNAL.PONE.0007112 Variant Set Distributions Ripley’s K […]
General Structure Information 1sko LAMTOR3 mp1-p14 complex 2.0Å AUTH V.V.LUNIN,C.MUNGER,J.WAGNER,Z.YE,M.CYGLER,M.SACHERTITL THE STRUCTURE OF THE MAP KINASE SCAFFOLD MP1 BOUNDTITL 2 TO ITS PARTNER P14: A COMPLEX WITH A CRITICAL ROLETITL 3 IN ENDOSOMAL MAP KINASE SIGNALINGREF J.BIOL.CHEM. V. 279 23422 2004REFN ISSN 0021-9258PMID 15016825DOI 10.1074/JBC.M401648200 Variant Set Distributions Mapped Variants
General Structure Information 2dae TAB2 solution structure of the n-terminal cue domain in the human mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (map3k7ip2) -1.0Å AUTH C.ZHAO,T.KIGAWA,M.SATO,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL CUE DOMAIN INTITL 2 THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASETITL 3 KINASE 7 INTERACTING PROTEIN 2 (MAP3K7IP2)REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3ose MARK1 structure of the kinase associated domain 1 (ka1) from mark1 kinase 1.7Å AUTH K.MORAVCEVIC,J.M.MENDROLA,K.R.SCHMITZ,Y.H.WANG,D.SLOCHOWER,AUTH 2 P.A.JANMEY,M.A.LEMMONTITL KINASE ASSOCIATED-1 DOMAINS DRIVE MARK/PAR1 KINASES TOTITL 2 MEMBRANE TARGETS BY BINDING ACIDIC PHOSPHOLIPIDS.REF CELL(CAMBRIDGE,MASS.) V. 143 966 2010REFN ISSN 0092-8674PMID 21145462DOI 10.1016/J.CELL.2010.11.028 Variant Set Distributions Mapped Variants
General Structure Information 4im0 TBK1 structure of tank-binding kinase 1 2.4Å AUTH D.TU,Z.ZHU,A.Y.ZHOU,C.YUN,K.LEE,A.V.TOMS,Y.LI,G.P.DUNN,AUTH 2 E.CHAN,T.THAI,S.YANG,S.B.FICARRO,J.A.MARTO,H.JEON,W.C.HAHN,AUTH 3 D.A.BARBIE,M.J.ECKTITL STRUCTURE OF TANK-BINDING KINASE 1REF CELL.REPORTS. 2013REFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants