General Structure Information
| PDB ID | 4i6h |
| HGNC Gene Label(s) | PLK2 |
| Structure Name | selective & brain-permeable polo-like kinase-2 (plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain |
| Resolution | 1.91Å |
| Reference | AUTH D.L.AUBELE,R.K.HOM,M.ADLER,R.A.GALEMMO,S.BOWERS,A.P.TRUONG,AUTH 2 H.PAN,P.BEROZA,R.J.NEITZ,N.YAO,M.LIN,G.TONN,H.ZHANG,AUTH 3 M.P.BOVA,Z.REN,D.TAM,L.RUSLIM,J.BAKER,L.DIEP,K.FITZGERALD,AUTH 4 J.HOFFMAN,R.MOTTER,D.FAUSS,P.TANAKA,M.DAPPEN,J.JAGODZINSKI,AUTH 5 W.CHAN,A.W.KONRADI,L.LATIMER,Y.L.ZHU,H.L.SHAM,J.P.ANDERSON,AUTH 6 M.BERGERON,D.R.ARTISTITL SELECTIVE & BRAIN-PERMEABLE POLO-LIKE KINASE-2 (PLK-2)TITL 2 INHIBITORS THAT REDUCE ALPHA-SYNUCLEIN PHOSPHORYLATION INTITL 3 RAT BRAINREF CHEMMEDCHEM V. 8 1295 2013REFN ISSN 1860-7179PMID 23794260DOI 10.1002/CMDC.201300166 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 285 |
| Number Of SNVs | 26 |
| Number Of Permutations | 12762 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.166 |
| p-value | 0.614 |
COSMIC
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
