Assessment of Structural Intolerance and Durability
General Structure Information 2hlq BMPR2 crystal structure of the extracellular domain of the type ii bmp receptor 1.45Å AUTH P.D.MACE,J.F.CUTFIELD,S.M.CUTFIELDTITL HIGH RESOLUTION STRUCTURES OF THE BONETITL 2 MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN TWOTITL 3 CRYSTAL FORMS: IMPLICATIONS FOR LIGAND BINDINGREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 351 831 2006REFN ISSN 0006-291XPMID 17094948DOI 10.1016/J.BBRC.2006.10.109 Variant Set Distributions Mapped Variants
General Structure Information 2c5d GAS6 structure of a minimal gas6-axl complex 3.3Å AUTH T.SASAKI,P.G.KNYAZEV,N.J.CLOUT,Y.CHEBURKIN,AUTH 2 W.GOEHRING,A.ULLRICH,R.TIMPL,E.HOHENESTERTITL STRUCTURAL BASIS FOR GAS6-AXL SIGNALLING.REF EMBO J. V. 25 80 2006REFN ISSN 0261-4189PMID 16362042DOI 10.1038/SJ.EMBOJ.7600912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2w2c CAMK2D structure of the tetradecameric oligomerisation domain of calcium-calmodulin dependent protein kinase ii delta 2.7Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 3fzt PTK2B crystal structure of pyk2 complexed with pf-4618433 1.95Å AUTH S.HAN,A.MISTRY,J.S.CHANG,D.CUNNINGHAM,M.GRIFFOR,AUTH 2 P.C.BONNETTE,H.WANG,B.A.CHRUNYK,G.E.ASPNES,AUTH 3 D.P.WALKER,A.D.BROSIUS,L.BUCKBINDERTITL STRUCTURAL CHARACTERIZATION OF PROLINE-RICHTITL 2 TYROSINE KINASE 2 (PYK2) REVEALS A UNIQUE (DFG-OUT)TITL 3 CONFORMATION AND ENABLES INHIBITOR DESIGN.REF J.BIOL.CHEM. V. 284 13193 2009REFN ISSN 0021-9258PMID 19244237DOI 10.1074/JBC.M809038200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4itj RIPK1 crystal structure of rip1 kinase in complex with necrostatin-4 1.8Å AUTH T.XIE,W.PENG,Y.LIU,C.YAN,J.MAKI,A.DEGTEREV,J.YUAN,Y.SHITITL STRUCTURAL BASIS OF RIP1 INHIBITION BY NECROSTATINS.REF STRUCTURE V. 21 493 2013REFN ISSN 0969-2126PMID 23473668DOI 10.1016/J.STR.2013.01.016 Variant Set Distributions Mapped Variants
General Structure Information 4itj RIPK1 crystal structure of rip1 kinase in complex with necrostatin-4 1.8Å AUTH T.XIE,W.PENG,Y.LIU,C.YAN,J.MAKI,A.DEGTEREV,J.YUAN,Y.SHITITL STRUCTURAL BASIS OF RIP1 INHIBITION BY NECROSTATINS.REF STRUCTURE V. 21 493 2013REFN ISSN 0969-2126PMID 23473668DOI 10.1016/J.STR.2013.01.016 Variant Set Distributions Mapped Variants
General Structure Information 4itj RIPK1 crystal structure of rip1 kinase in complex with necrostatin-4 1.8Å AUTH T.XIE,W.PENG,Y.LIU,C.YAN,J.MAKI,A.DEGTEREV,J.YUAN,Y.SHITITL STRUCTURAL BASIS OF RIP1 INHIBITION BY NECROSTATINS.REF STRUCTURE V. 21 493 2013REFN ISSN 0969-2126PMID 23473668DOI 10.1016/J.STR.2013.01.016 Variant Set Distributions Mapped Variants
General Structure Information 2z7q RPS6KA1 crystal structure of the n-terminal kinase domain of human rsk-1 bound to amp-pcp 2.0Å AUTH M.IKUTA,M.KORNIENKO,N.BYRNE,J.C.REID,S.MIZUARAI,H.KOTANI,AUTH 2 S.K.MUNSHITITL CRYSTAL STRUCTURES OF THE N-TERMINAL KINASE DOMAIN OF HUMANTITL 2 RSK1 BOUND TO THREE DIFFERENT LIGANDS: IMPLICATIONS FOR THETITL 3 DESIGN OF RSK1 SPECIFIC INHIBITORS.REF PROTEIN SCI. V. 16 2626 2007REFN ISSN […]
General Structure Information 2wnt RPS6KA1 crystal structure of the human ribosomal protein s6 kinase 2.4Å AUTH J.R.C.MUNIZ,J.M.ELKINS,J.WANG,E.UGOCHUKWU,E.SALAH,AUTH 2 O.KING,S.PICAUD,F.VON DELFT,C.BOUNTRA,AUTH 3 C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN RIBOSOMAL PROTEINTITL 2 S6 KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants