Assessment of Structural Intolerance and Durability
General Structure Information 1×51 MUTYH solution structure of the nudix domain from human a/g- specific adenine dna glycosylase alpha-3 splice isoform -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE NUDIX DOMAIN FROM HUMANTITL 2 A/G-SPECIFIC ADENINE DNA GLYCOSYLASE ALPHA-3TITL 3 SPLICE ISOFORMREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3mb4 PBRM1 crystal structure of the fifth bromodomain of human poly-bromodomain containing protein 1 (pb1) with nmp 1.66Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 3tlp PBRM1 crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (pb1) 2.13Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 3iu6 PBRM1 crystal structure of the sixth bromodomain of human poly-bromodomain containing protein 1 (pb1) 1.79Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3k2j PBRM1 crystal structure of the 3rd bromodomain of human poly-bromodomain containing protein 1 (pb1) 2.2Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,T.KEATES,A.CHAIKUAD,A.C.W.PIKE,AUTH 2 T.KROJER,R.SETHI,F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 J.WEIGELT,C.BOUNTRA,S.KNAPPTITL CRYSTAL STRUCTURE OF THE 3RD BROMODOMAIN OF HUMANTITL 2 POLY-BROMODOMAIN CONTAINING PROTEIN 1 (PB1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2e5s MBNL2 solution structure of the zf-ccchx2 domain of muscleblind- like 2, isoform 1 [homo sapiens] -1.0Å AUTH F.HE,W.DANG,C.ABE,K.TSUDA,M.INOUE,S.WATANABE,AUTH 2 N.KOBAYASHI,T.KIGAWA,T.MATSUDA,T.YABUKI,M.AOKI,AUTH 3 E.SEKI,T.HARADA,Y.TOMABECHI,T.TERADA,M.SHIROUZU,AUTH 4 A.TANAKA,P.GUNTERT,Y.MUTO,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA BINDING DOMAIN INTITL 2 THE HUMAN MUSCLEBLIND-LIKE PROTEIN 2REF PROTEIN SCI. V. 18 80 2009REFN ISSN 0961-8368PMID 19177353DOI 10.1002/PRO.17 Variant Set Distributions […]
General Structure Information 2yqp DDX59 solution structure of the zf-hit domain in dead (asp-glu- ala-asp) box polypeptide 59 -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TARADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-HIT DOMAIN IN DEADTITL 2 (ASP-GLU-ALA-ASP) BOX POLYPEPTIDE 59REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2edn MYBPC2 solution structure of the first ig-like domain from human myosin-binding protein c, fast-type -1.0Å AUTH K.NAGASHIMA,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST IG-LIKE DOMAINTITL 2 FROM HUMAN MYOSIN-BINDING PROTEIN C, FAST-TYPEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3rcq ASPH crystal structure of human aspartate beta-hydroxylase isoform a 2.05Å AUTH T.KROJER,G.KOCHAN,E.PILKA,V.HOZJAN,C.K.ALLERSTON,J.BRAY,AUTH 2 J.R.MUNIZ,A.CHAIKUAD,O.GILEADI,K.KAVANAGH,F.VON DELFT,AUTH 3 C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN ASPARTATE BETA-HYDROXYLASETITL 2 ISOFORM AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hlz KHK crystal structure of human ketohexokinase (casp target) 1.85Å AUTH W.M.RABEH,W.TEMPEL,L.NEDYALKOVA,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN KETOHEXOKINASE (CASPTITL 2 TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants