Assessment of Structural Intolerance and Durability
General Structure Information 3mdv CYP46A1 clotrimazole complex of cytochrome p450 46a1 2.4Å AUTH N.MAST,C.CHARVET,I.A.PIKULEVA,C.D.STOUTTITL STRUCTURAL BASIS OF DRUG BINDING TO CYP46A1, AN ENZYME THATTITL 2 CONTROLS CHOLESTEROL TURNOVER IN THE BRAIN.REF J.BIOL.CHEM. V. 285 31783 2010REFN ISSN 0021-9258PMID 20667828DOI 10.1074/JBC.M110.143313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3u9j FBXL5 crystal structure of oxidized human fbxl5 hemerythrin like domain 1.6Å AUTH C.SHU,M.W.SUNG,M.D.STEWART,T.I.IGUMENOVA,X.TAN,P.LITITL THE STRUCTURAL BASIS OF IRON SENSING BY THE HUMAN F-BOXTITL 2 PROTEIN FBXL5.REF CHEMBIOCHEM V. 13 788 2012REFN ISSN 1439-4227PMID 22492618DOI 10.1002/CBIC.201200043 Variant Set Distributions Mapped Variants
General Structure Information 3d8c HIF1AN factor inhibiting hif-1 alpha d201g mutant in complex with zn(ii), alpha-ketoglutarate and hif-1 alpha 19mer 2.1Å AUTH K.S.HEWITSON,S.L.HOLMES,D.EHRISMANN,A.P.HARDY,R.CHOWDHURY,AUTH 2 C.J.SCHOFIELD,M.A.MCDONOUGHTITL EVIDENCE THAT TWO ENZYME-DERIVED HISTIDINE LIGANDS ARETITL 2 SUFFICIENT FOR IRON BINDING AND CATALYSIS BY FACTORTITL 3 INHIBITING HIF (FIH).REF J.BIOL.CHEM. V. 283 25971 2008REFN ISSN 0021-9258PMID 18611856DOI 10.1074/JBC.M804999200 Variant […]
General Structure Information 3p4l NEO1 crystal structure of a hemojuvelin-binding fragment of neogenin 1.8Å AUTH F.YANG,A.P.WEST,P.J.BJORKMANTITL CRYSTAL STRUCTURE OF A HEMOJUVELIN-BINDING FRAGMENT OFTITL 2 NEOGENIN AT 1.8A.REF J.STRUCT.BIOL. V. 174 239 2011REFN ISSN 1047-8477PMID 20971194DOI 10.1016/J.JSB.2010.10.005 Variant Set Distributions Mapped Variants
General Structure Information 3le4 DGCR8 crystal structure of the dgcr8 dimerization domain 1.7Å AUTH R.SENTURIA,M.FALLER,S.YIN,J.A.LOO,D.CASCIO,M.R.SAWAYA,AUTH 2 D.HWANG,R.T.CLUBB,F.GUOTITL STRUCTURE OF THE DIMERIZATION DOMAIN OF DIGEORGE CRITICALTITL 2 REGION 8REF PROTEIN SCI. V. 19 1354 2010REFN ISSN 0961-8368PMID 20506313DOI 10.1002/PRO.414 Variant Set Distributions Mapped Variants
General Structure Information 1r03 FTMT crystal structure of a human mitochondrial ferritin 1.7Å AUTH B.LANGLOIS DESTAINTOT,P.SANTAMBROGIO,T.GRANIER,B.GALLOIS,AUTH 2 J.M.CHEVALLIER,G.PRECIGOUX,S.LEVI,P.AROSIOTITL CRYSTAL STRUCTURE AND BIOCHEMICAL PROPERTIES OF THE HUMANTITL 2 MITOCHONDRIAL FERRITIN AND ITS MUTANT SER144ALAREF J.MOL.BIOL. V. 340 277 2004REFN ISSN 0022-2836PMID 15201052DOI 10.1016/J.JMB.2004.04.036 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3hf1 RRM2B crystal structure of human p53r2 2.6Å AUTH P.SMITH,B.ZHOU,N.HO,Y.C.YUAN,L.SU,S.C.TSAI,Y.YENTITL 2.6 A X-RAY CRYSTAL STRUCTURE OF HUMAN P53R2, ATITL 2 P53-INDUCIBLE RIBONUCLEOTIDE REDUCTASE .REF BIOCHEMISTRY V. 48 11134 2009REFN ISSN 0006-2960PMID 19728742DOI 10.1021/BI9001425 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ekg FXN mature human frataxin 1.8Å AUTH S.DHE-PAGANON,R.SHIGETA,Y.I.CHI,M.RISTOW,AUTH 2 S.E.SHOELSONTITL CRYSTAL STRUCTURE OF HUMAN FRATAXIN.REF J.BIOL.CHEM. V. 275 30753 2000REFN ISSN 0021-9258PMID 10900192DOI 10.1074/JBC.C000407200 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fga SGOL1 structural basis of pp2a and sgo interaction 2.7Å AUTH Z.XU,B.CETIN,M.ANGER,U.S.CHO,W.HELMHART,K.NASMYTH,W.XUTITL STRUCTURE AND FUNCTION OF THE PP2A-SHUGOSHIN INTERACTIONREF MOL.CELL V. 35 426 2009REFN ISSN 1097-2765PMID 19716788DOI 10.1016/J.MOLCEL.2009.06.031 Variant Set Distributions Mapped Variants
General Structure Information 3czh CYP2R1 crystal structure of cyp2r1 in complex with vitamin d2 2.3Å AUTH N.V.STRUSHKEVICH,W.TEMPEL,A.A.GILEP,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITHTITL 2 VITAMIN D2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants