Assessment of Structural Intolerance and Durability
General Structure Information 3lq9 DDIT4 crystal strucure of human redd1, a hypoxia-induced regulator of mtor 2.0Å AUTH S.VEGA-RUBIN-DE-CELIS,Z.ABDALLAH,L.KINCH,AUTH 2 N.V.GRISHIN,J.BRUGAROLAS,X.ZHANGTITL STRUCTURAL ANALYSIS AND FUNCTIONAL IMPLICATIONS OFTITL 2 THE NEGATIVE MTORC1 REGULATOR REDD1.REF BIOCHEMISTRY V. 49 2491 2010REFN ISSN 0006-2960PMID 20166753DOI 10.1021/BI902135E Variant Set Distributions Mapped Variants
General Structure Information 3d8c HIF1AN factor inhibiting hif-1 alpha d201g mutant in complex with zn(ii), alpha-ketoglutarate and hif-1 alpha 19mer 2.1Å AUTH K.S.HEWITSON,S.L.HOLMES,D.EHRISMANN,A.P.HARDY,R.CHOWDHURY,AUTH 2 C.J.SCHOFIELD,M.A.MCDONOUGHTITL EVIDENCE THAT TWO ENZYME-DERIVED HISTIDINE LIGANDS ARETITL 2 SUFFICIENT FOR IRON BINDING AND CATALYSIS BY FACTORTITL 3 INHIBITING HIF (FIH).REF J.BIOL.CHEM. V. 283 25971 2008REFN ISSN 0021-9258PMID 18611856DOI 10.1074/JBC.M804999200 Variant […]
General Structure Information 4h6j HIF1A identification of cys 255 in hif-1 as a novel site for development of covalent inhibitors of hif-1 /arnt pasb domain protein-protein interaction. 1.52Å AUTH R.CARDOSO,R.LOVE,C.L.NILSSON,S.BERGQVIST,D.NOWLIN,J.YAN,AUTH 2 K.K.LIU,J.ZHU,P.CHEN,Y.L.DENG,H.J.DYSON,M.J.GREIG,A.BROOUNTITL IDENTIFICATION OF CYS255 IN HIF-1 ALPHA AS A NOVEL SITE FORTITL 2 DEVELOPMENT OF COVALENT INHIBITORS OF HIF-1 ALPHA /ARNT PASBTITL 3 DOMAIN […]
General Structure Information 4b95 TCEB1 pvhl-elob-elob-elocc complex_(2s,4r)-1-(2-chlorophenyl)carbonyl-n-[ (4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound 2.8Å AUTH D.L.BUCKLEY,J.L.GUSTAFSON,I.VAN MOLLE,A.G.ROTH,H.S.TAE,AUTH 2 P.C.GAREISS,W.L.JORGENSEN,A.CIULLI,C.M.CREWSTITL SMALL-MOLECULE INHIBITORS OF THE INTERACTION BETWEEN THE E3TITL 2 LIGASE VHL AND HIF1ALPHAREF ANGEW.CHEM.INT.ED.ENGL. V. 51 11463 2012REFN ISSN 1433-7851PMID 23065727DOI 10.1002/ANIE.201206231 Variant Set Distributions Mapped Variants
General Structure Information 4b95 TCEB1 pvhl-elob-elob-elocc complex_(2s,4r)-1-(2-chlorophenyl)carbonyl-n-[ (4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound 2.8Å AUTH D.L.BUCKLEY,J.L.GUSTAFSON,I.VAN MOLLE,A.G.ROTH,H.S.TAE,AUTH 2 P.C.GAREISS,W.L.JORGENSEN,A.CIULLI,C.M.CREWSTITL SMALL-MOLECULE INHIBITORS OF THE INTERACTION BETWEEN THE E3TITL 2 LIGASE VHL AND HIF1ALPHAREF ANGEW.CHEM.INT.ED.ENGL. V. 51 11463 2012REFN ISSN 1433-7851PMID 23065727DOI 10.1002/ANIE.201206231 Variant Set Distributions Mapped Variants