Assessment of Structural Intolerance and Durability
General Structure Information 3gni STRADA structure of strad and mo25 2.35Å AUTH E.ZEQIRAJ,B.M.FILIPPI,S.GOLDIE,I.NAVRATILOVA,J.BOUDEAU,AUTH 2 M.DEAK,D.R.ALESSI,D.M.VAN AALTENTITL ATP AND MO25ALPHA REGULATE THE CONFORMATIONAL STATE OF THETITL 2 STRADALPHA PSEUDOKINASE AND ACTIVATION OF THE LKB1 TUMOURTITL 3 SUPPRESSORREF PLOS BIOL. V. 7 E1000 2009REFN ISSN 1544-9173PMID 19513107DOI 10.1371/JOURNAL.PBIO.1000126 Variant Set Distributions Mapped Variants
General Structure Information 1urf PKN1 hr1b domain from prk1 -1.0Å AUTH D.OWEN,P.N.LOWE,D.NIETLISPACH,C.E.BROSNAN,AUTH 2 D.Y.CHIRGADZE,P.J.PARKER,T.L.BLUNDELL,H.R.MOTTTITL MOLECULAR DISSECTION OF THE INTERACTION BETWEENTITL 2 THE SMALL G PROTEINS RAC1 AND RHOA AND PROTEINTITL 3 KINASE C-RELATED KINASE 1 (PRK1)REF J.BIOL.CHEM. V. 278 50578 2003REFN ISSN 0021-9258PMID 14514689DOI 10.1074/JBC.M304313200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4doh IL20RB il20/il201/il20r2 ternary complex 2.8Å AUTH N.J.LOGSDON,A.DESHPANDE,B.D.HARRIS,K.R.RAJASHANKAR,AUTH 2 M.R.WALTERTITL STRUCTURAL BASIS FOR RECEPTOR SHARING AND ACTIVATION BYTITL 2 INTERLEUKIN-20 RECEPTOR-2 (IL-20R2) BINDING CYTOKINES.REF PROC.NATL.ACAD.SCI.USA V. 109 12704 2012REFN ISSN 0027-8424PMID 22802649DOI 10.1073/PNAS.1117551109 Variant Set Distributions Mapped Variants
General Structure Information 3l4h HECW1 helical box domain and second ww domain of the human e3 ubiquitin- protein ligase hecw1 1.8Å AUTH J.R.WALKER,L.QIU,Y.LI,J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL THE TANDEM HELICAL BOX AND SECOND WW DOMAINS OF HUMAN HECW1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f31 SPTAN1 crystal structure of the n-terminal region of alphaii-spectrin tetramerization domain 2.3Å AUTH S.MEHBOOB,Y.SONG,M.WITEK,F.LONG,B.D.SANTARSIERO,AUTH 2 M.E.JOHNSON,L.W.FUNGTITL CRYSTAL STRUCTURE OF THE NONERYTHROID ALPHA-SPECTRINTITL 2 TETRAMERIZATION SITE REVEALS DIFFERENCES BETWEEN ERYTHROIDTITL 3 AND NONERYTHROID SPECTRIN TETRAMER FORMATION.REF J.BIOL.CHEM. V. 285 14572 2010REFN ISSN 0021-9258PMID 20228407DOI 10.1074/JBC.M109.080028 Variant Set Distributions Mapped Variants
General Structure Information 2lcx ERBB4 spatial structure of the erbb4 dimeric tm domain -1.0Å AUTH E.V.BOCHAROV,K.S.MINEEV,M.V.GONCHARUK,A.S.ARSENIEVTITL STRUCTURAL AND THERMODYNAMIC INSIGHT INTO THE PROCESS OFTITL 2 WEAK DIMERIZATION OF THE ERBB4 TRANSMEMBRANE DOMAIN BYTITL 3 SOLUTION NMR.REF BIOCHIM.BIOPHYS.ACTA V.1818 2158 2012REFN ISSN 0006-3002PMID 22579757DOI 10.1016/J.BBAMEM.2012.05.001 Variant Set Distributions Mapped Variants
General Structure Information 3pja TSN crystal structure of human c3po complex 3.0Å AUTH X.YE,N.HUANG,Y.LIU,Z.PAROO,C.HUERTA,P.LI,S.CHEN,Q.LIU,AUTH 2 H.ZHANGTITL STRUCTURE OF C3PO AND MECHANISM OF HUMAN RISC ACTIVATION.REF NAT.STRUCT.MOL.BIOL. V. 18 650 2011REFN ISSN 1545-9993PMID 21552258DOI 10.1038/NSMB.2032 Variant Set Distributions Mapped Variants
General Structure Information 2hye CUL4A crystal structure of the ddb1-cul4a-rbx1-sv5v complex 3.1Å AUTH S.ANGERS,T.LI,X.YI,M.J.MACCOSS,R.T.MOON,N.ZHENGTITL MOLECULAR ARCHITECTURE AND ASSEMBLY OF THETITL 2 DDB1-CUL4A UBIQUITIN LIGASE MACHINERY.REF NATURE V. 443 590 2006REFN ISSN 0028-0836PMID 16964240DOI 10.1038/NATURE05175 Variant Set Distributions Mapped Variants
General Structure Information 2hye CUL4A crystal structure of the ddb1-cul4a-rbx1-sv5v complex 3.1Å AUTH S.ANGERS,T.LI,X.YI,M.J.MACCOSS,R.T.MOON,N.ZHENGTITL MOLECULAR ARCHITECTURE AND ASSEMBLY OF THETITL 2 DDB1-CUL4A UBIQUITIN LIGASE MACHINERY.REF NATURE V. 443 590 2006REFN ISSN 0028-0836PMID 16964240DOI 10.1038/NATURE05175 Variant Set Distributions Mapped Variants
General Structure Information 2hye CUL4A crystal structure of the ddb1-cul4a-rbx1-sv5v complex 3.1Å AUTH S.ANGERS,T.LI,X.YI,M.J.MACCOSS,R.T.MOON,N.ZHENGTITL MOLECULAR ARCHITECTURE AND ASSEMBLY OF THETITL 2 DDB1-CUL4A UBIQUITIN LIGASE MACHINERY.REF NATURE V. 443 590 2006REFN ISSN 0028-0836PMID 16964240DOI 10.1038/NATURE05175 Variant Set Distributions Mapped Variants