Assessment of Structural Intolerance and Durability
General Structure Information 1n83 RORA crystal structure of the complex between the orphan nuclear hormone receptor ror(alpha)-lbd and cholesterol 1.63Å AUTH J.A.KALLEN,J.M.SCHLAEPPI,F.BITSCH,S.GEISSE,AUTH 2 M.GEISER,I.DELHON,B.FOURNIERTITL X-RAY STRUCTURE OF HROR(ALPHA) LBD AT 1.63A:TITL 2 STRUCTURAL AND FUNCTIONAL DATA THAT CHOLESTEROL ORTITL 3 A CHOLESTEROL DERIVATIVE IS THE NATURAL LIGAND OFTITL 4 ROR(ALPHA)REF STRUCTURE V. 10 1697 2002REFN […]
General Structure Information 1ax8 LEP human obesity protein, leptin 2.4Å AUTH F.ZHANG,M.B.BASINSKI,J.M.BEALS,S.L.BRIGGS,L.M.CHURGAY,AUTH 2 D.K.CLAWSON,R.D.DIMARCHI,T.C.FURMAN,J.E.HALE,H.M.HSIUNG,AUTH 3 B.E.SCHONER,D.P.SMITH,X.Y.ZHANG,J.P.WERY,R.W.SCHEVITZTITL CRYSTAL STRUCTURE OF THE OBESE PROTEIN LEPTIN-E100.REF NATURE V. 387 206 1997REFN ISSN 0028-0836PMID 9144295DOI 10.1038/387206A0 Variant Set Distributions Mapped Variants
General Structure Information 1elr STIP1 crystal structure of the tpr2a domain of hop in complex with the hsp90 peptide meevd 1.9Å AUTH C.SCHEUFLER,A.BRINKER,G.BOURENKOV,S.PEGORARO,AUTH 2 L.MORODER,H.BARTUNIK,F.U.HARTL,I.MOAREFITITL STRUCTURE OF TPR DOMAIN-PEPTIDE COMPLEXES:TITL 2 CRITICAL ELEMENTS IN THE ASSEMBLY OF THETITL 3 HSP70-HSP90 MULTICHAPERONE MACHINE.REF CELL(CAMBRIDGE,MASS.) V. 101 199 2000REFN ISSN 0092-8674PMID 10786835DOI 10.1016/S0092-8674(00)80830-2 Variant Set Distributions Mapped […]
General Structure Information 2jrz KDM5C solution structure of the bright/arid domain from the human jarid1c protein. -1.0Å AUTH C.KOEHLER,S.BISHOP,E.F.DOWLER,P.SCHMIEDER,A.DIEHL,AUTH 2 H.OSCHKINAT,L.J.BALLTITL BACKBONE AND SIDECHAIN 1H, 13C AND 15N RESONANCETITL 2 ASSIGNMENTS OF THE BRIGHT/ARID DOMAIN FROM THETITL 3 HUMAN JARID1C (SMCX) PROTEIN.REF BIOMOL.NMR ASSIGN. V. 2 9 2008REFN ISSN 1874-2718PMID 19636912DOI 10.1007/S12104-007-9071-7 Variant Set Distributions […]
General Structure Information 4bwe GPC1 crystal structure of c-terminally truncated glypican-1 after controlled dehydration to 86 percent relative humidity 2.46Å AUTH W.AWAD,G.SVENSSON BIRKEDAL,M.M.G.M.THUNNISSEN,K.MANI,AUTH 2 D.T.LOGANTITL IMPROVEMENTS OF THE ORDER, ISOTROPY AND ELECTRON DENSITY OFTITL 2 GLYPICAN-1 CRYSTALS BY CONTROLLED DEHYDRATIONREF ACTA CRYSTALLOGR.,SECT.D V. 69 2524 2013REFN ISSN 0907-4449PMID 24311593DOI 10.1107/S0907444913025250 Variant Set Distributions Ripley’s K […]
General Structure Information 2l27 CRHR1 nmr structure of the ecd1 of crf-r1 in complex with a peptide agonist -1.0Å AUTH C.R.GRACE,M.H.PERRIN,J.GULYAS,J.E.RIVIER,W.W.VALE,R.RIEKTITL NMR STRUCTURE OF THE FIRST EXTRACELLULAR DOMAIN OFTITL 2 CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (ECD1-CRF-R1)TITL 3 COMPLEXED WITH A HIGH AFFINITY AGONIST.REF J.BIOL.CHEM. V. 285 38580 2010REFN ISSN 0021-9258PMID 20843795DOI 10.1074/JBC.M110.121897 Variant Set Distributions Mapped […]
General Structure Information 3cjw NR2F2 crystal structure of the human coup-tfii ligand binding domain 1.48Å AUTH S.W.KRUSE,K.SUINO-POWELL,X.E.ZHOU,J.E.KRETSCHMAN,AUTH 2 R.REYNOLDS,C.VONRHEIN,Y.XU,L.WANG,S.Y.TSAI,AUTH 3 M.J.TSAI,H.E.XUTITL IDENTIFICATION OF COUP-TFII ORPHAN NUCLEARTITL 2 RECEPTOR AS A RETINOIC ACID-ACTIVATED RECEPTOR.REF PLOS BIOL. V. 6 E227 2008REFN ISSN 1544-9173PMID 18798693DOI 10.1371/JOURNAL.PBIO.0060227 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4l3i PRC1 structure of the microtubule associated protein prc1 (protein regulator of cytokinesis 1) 3.6Å AUTH R.SUBRAMANIAN,S.C.TI,L.TAN,S.A.DARST,T.M.KAPOORTITL MARKING AND MEASURING SINGLE MICROTUBULES BY PRC1 ANDTITL 2 KINESIN-4.REF CELL(CAMBRIDGE,MASS.) V. 154 377 2013REFN ISSN 0092-8674PMID 23870126DOI 10.1016/J.CELL.2013.06.021 Variant Set Distributions Mapped Variants