Assessment of Structural Intolerance and Durability
General Structure Information 4li0 RAB8A crystal structure of gdp-bound rab8:grab 3.3Å AUTH Z.GUO,X.HOU,R.S.GOODY,A.ITZENTITL INTERMEDIATES IN THE GUANINE NUCLEOTIDE EXCHANGE REACTION OFTITL 2 RAB8 PROTEIN CATALYZED BY GUANINE NUCLEOTIDE EXCHANGETITL 3 FACTORS RABIN8 AND GRAB.REF J.BIOL.CHEM. V. 288 32466 2013REFN ISSN 0021-9258PMID 24072714DOI 10.1074/JBC.M113.498329 Variant Set Distributions Mapped Variants
General Structure Information 4m8n RAP1B crystal structure of plexinc1/rap1b complex 3.29Å AUTH Y.WANG,H.G.PASCOE,C.A.BRAUTIGAM,H.HE,X.ZHANGTITL STRUCTURAL BASIS FOR ACTIVATION AND NON-CANONICAL CATALYSISTITL 2 OF THE RAP GTPASE ACTIVATING PROTEIN DOMAIN OF PLEXIN.REF ELIFE V. 2 01279 2013REFN ESSN 2050-084XPMID 24137545DOI 10.7554/ELIFE.01279 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1foe RAC1 crystal structure of rac1 in complex with the guanine nucleotide exchange region of tiam1 2.8Å AUTH D.K.WORTHYLAKE,K.L.ROSSMAN,J.SONDEKTITL CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THETITL 2 GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1.REF NATURE V. 408 682 2000REFN ISSN 0028-0836PMID 11130063DOI 10.1038/35047014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1z0a RAB2A gdp-bound rab2a gtpase 2.12Å AUTH S.EATHIRAJ,X.PAN,C.RITACCO,D.G.LAMBRIGHTTITL STRUCTURAL BASIS OF FAMILY-WIDE RAB GTPASETITL 2 RECOGNITION BY RABENOSYN-5.REF NATURE V. 436 415 2005REFN ISSN 0028-0836PMID 16034420DOI 10.1038/NATURE03798 Variant Set Distributions Mapped Variants
General Structure Information 3t6g BCAR1 structure of the complex between nsp3 (shep1) and p130cas 2.5Å AUTH P.D.MACE,Y.WALLEZ,M.K.DOBACZEWSKA,J.J.LEE,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL NSP-CAS PROTEIN STRUCTURES REVEAL A PROMISCUOUS INTERACTIONTITL 2 MODULE IN CELL SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 18 1381 2011REFN ISSN 1545-9993PMID 22081014DOI 10.1038/NSMB.2152 Variant Set Distributions Mapped Variants
General Structure Information 1wms RAB9A high resolution crystal structure of human rab9 gtpase: a novel antiviral drug target 1.25Å AUTH L.CHEN,E.DIGIAMMARINO,X.E.ZHOU,Y.WANG,D.TOH,AUTH 2 T.W.HODGE,E.J.MEEHANTITL HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN RAB9TITL 2 GTPASE: A NOVEL ANTIVIRAL DRUG TARGETREF J.BIOL.CHEM. V. 279 40204 2004REFN ISSN 0021-9258PMID 15263003DOI 10.1074/JBC.M407114200 Variant Set Distributions Mapped Variants
General Structure Information 1rrp RANBP2 structure of the ran-gppnhp-ranbd1 complex 2.96Å AUTH I.R.VETTER,C.NOWAK,T.NISHIMOTO,J.KUHLMANN,AUTH 2 A.WITTINGHOFERTITL STRUCTURE OF A RAN-BINDING DOMAIN COMPLEXED WITHTITL 2 RAN BOUND TO A GTP ANALOGUE: IMPLICATIONS FORTITL 3 NUCLEAR TRANSPORT.REF NATURE V. 398 39 1999REFN ISSN 0028-0836PMID 10078529DOI 10.1038/17969 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1cc0 ARHGDIA crystal structure of the rhoa.gdp-rhogdi complex 5.0Å AUTH K.LONGENECKER,P.READ,U.DEREWENDA,Z.DAUTER,X.LIU,AUTH 2 S.GARRARD,L.WALKER,A.V.SOMLYO,R.K.NAKAMOTO,AUTH 3 A.P.SOMLYO,Z.S.DEREWENDATITL HOW RHOGDI BINDS RHO.REF ACTA CRYSTALLOGR.,SECT.D V. 55 1503 1999REFN ISSN 0907-4449PMID 10489445DOI 10.1107/S090744499900801X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3l82 TERF1 x-ray crystal structure of trf1 and fbx4 complex 2.4Å AUTH Z.ZENG,W.WANG,Y.YANG,Y.CHEN,X.YANG,J.A.DIEHL,X.LIU,M.LEITITL STRUCTURAL BASIS OF SELECTIVE UBIQUITINATION OF TRF1 BYTITL 2 SCF(FBX4)REF DEV.CELL V. 18 214 2010REFN ISSN 1534-5807PMID 20159592DOI 10.1016/J.DEVCEL.2010.01.007 Variant Set Distributions Mapped Variants
General Structure Information 2hxs RAB28 crystal structure of rab28a gtpase in the inactive (gdp-3p- bound) form 1.1Å AUTH S.H.LEE,Y.LI,R.DOMINGUEZTITL THE CRYSTAL STRUCTURE OF RAB28 GTPASE IN ACTIVETITL 2 AND INACTIVE FORMSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants