Assessment of Structural Intolerance and Durability
General Structure Information 2gco RHOC crystal structure of the human rhoc-gppnhp complex 1.4Å AUTH S.M.G.DIAS,R.A.CERIONETITL X-RAY CRYSTAL STRUCTURES REVEAL TWO ACTIVATED STATES FORTITL 2 RHOC.REF BIOCHEMISTRY V. 46 6547 2007REFN ISSN 0006-2960PMID 17497936DOI 10.1021/BI700035P Variant Set Distributions Mapped Variants
General Structure Information 2ke5 RALB solution structure and dynamics of the small gtpase ralb in its active conformation: significance for effector protein binding -1.0Å AUTH R.B.FENWICK,S.PRASANNAN,L.J.CAMPBELL,D.NIETLISPACH,AUTH 2 K.A.EVETTS,J.CAMONIS,H.R.MOTT,D.OWENTITL SOLUTION STRUCTURE AND DYNAMICS OF THE SMALL GTPASETITL 2 RALB IN ITS ACTIVE CONFORMATION: SIGNIFICANCE FORTITL 3 EFFECTOR PROTEIN BINDINGREF BIOCHEMISTRY V. 48 2192 2009REFN ISSN 0006-2960PMID […]
General Structure Information 4lpk KRAS crystal structure of k-ras wt, gdp-bound 1.5Å AUTH J.M.OSTREM,U.PETERS,M.L.SOS,J.A.WELLS,K.M.SHOKATTITL K-RAS(G12C) INHIBITORS ALLOSTERICALLY CONTROL GTP AFFINITYTITL 2 AND EFFECTOR INTERACTIONS.REF NATURE V. 503 548 2013REFN ISSN 0028-0836PMID 24256730DOI 10.1038/NATURE12796 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3con NRAS crystal structure of the human nras gtpase bound with gdp 1.65Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.SHEN,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN NRAS GTPASE BOUNDTITL 2 WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4g0n RAF1 crystal structure of wt h-ras-gppnhp bound to the rbd of raf kinase 2.45Å AUTH S.K.FETICS,H.GUTERRES,B.M.KEARNEY,G.BUHRMAN,B.MA,R.NUSSINOV,AUTH 2 C.MATTOSTITL ALLOSTERIC EFFECTS OF THE ONCOGENIC RASQ61L MUTANT ONTITL 2 RAF-RBD.REF STRUCTURE V. 23 505 2015REFN ISSN 0969-2126PMID 25684575DOI 10.1016/J.STR.2014.12.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1nty TRIO crystal structure of the first dh/ph domain of trio to 1.7 a 1.7Å AUTH K.R.SKOWRONEK,F.GUO,Y.ZHENG,N.NASSARTITL THE C-TERMINAL BASIC TAIL OF RHOG ASSISTS THE GUANINETITL 2 NUCLEOTIDE EXCHANGE FACTOR TRIO IN BINDING TO PHOSPHOLIPIDS.REF J.BIOL.CHEM. V. 279 37895 2004REFN ISSN 0021-9258PMID 15199069DOI 10.1074/JBC.M312677200 Variant Set Distributions Mapped Variants
General Structure Information 2j1l RHOD crystal structure of human rho-related gtp-binding protein rhod 2.5Å AUTH A.C.W.PIKE,C.JOHANSSON,C.GILEADI,F.H.NIESEN,F.SOBOTT,AUTH 2 G.SCHOCH,J.ELKINS,C.SMEE,F.GORREC,S.WATT,J.BRAY,AUTH 3 A.P.TURNBULL,F.VON DELFT,C.ARROWSMITH,A.EDWARDS,J.WEIGELT,AUTH 4 M.SUNDSTROM,D.DOYLETITL CRYSTAL STRUCTURE OF HUMAN RHO-RELATED GTP-BINDING PROTEINTITL 2 RHODREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4hdo KRIT1 crystal structure of the binary complex of krit1 bound to the rap1 gtpase 1.67Å AUTH A.R.GINGRAS,W.PUZON-MCLAUGHLIN,M.H.GINSBERGTITL THE STRUCTURE OF THE TERNARY COMPLEX OF KREV INTERACTIONTITL 2 TRAPPED 1 (KRIT1) BOUND TO BOTH THE RAP1 GTPASE AND THETITL 3 HEART OF GLASS (HEG1) CYTOPLASMIC TAIL.REF J.BIOL.CHEM. V. 288 23639 2013REFN ISSN […]