Assessment of Structural Intolerance and Durability
General Structure Information 2h16 ARL5A structure of human adp-ribosylation factor-like 5 (arl5) 2.0Å AUTH W.M.RABEH,W.TEMPEL,D.YANIW,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 5TITL 2 (ARL5)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qwl TBC1D7 crystal structure of human tbc1 domain family member 7 1.9Å AUTH X.GUAN,W.TEMPEL,Y.TONG,A.K.WERNIMONT,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN TBC1 DOMAIN FAMILY MEMBER 7REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ed1 ASAP1 solution structure of the sh3 domain of 130 kda phosphatidylinositol 4,5-biphosphate-dependent arf1 gtpase- activating protein -1.0Å AUTH H.ABE,N.TOCHIO,K.MIYAMOTO,K.SAITO,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF 130 KDATITL 2 PHOSPHATIDYLINOSITOL 4,5-BIPHOSPHATE-DEPENDENTTITL 3 ARF1 GTPASE-ACTIVATING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3msx ARHGAP20 crystal structure of rhoa.gdp.mgf3 in complex with gap domain of arhgap20 1.65Å AUTH D.UTEPBERGENOV,D.R.COOPER,U.DEREWENDA,A.V.SOMLYO,AUTH 2 Z.S.DEREWENDATITL MECHANISM OF MOLECULAR SPECIFICITY OF RHOGAP DOMAINS TOWARDSTITL 2 SMALL GTPASES OF RHOA FAMILY.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3c5c RASL12 crystal structure of human ras-like, family 12 protein in complex with gdp 1.85Å AUTH L.SHEN,Y.TONG,W.TEMPEL,P.LOPPNAU,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAS-LIKE, FAMILY 12TITL 2 PROTEIN IN COMPLEX WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3l82 FBXO4 x-ray crystal structure of trf1 and fbx4 complex 2.4Å AUTH Z.ZENG,W.WANG,Y.YANG,Y.CHEN,X.YANG,J.A.DIEHL,X.LIU,M.LEITITL STRUCTURAL BASIS OF SELECTIVE UBIQUITINATION OF TRF1 BYTITL 2 SCF(FBX4)REF DEV.CELL V. 18 214 2010REFN ISSN 1534-5807PMID 20159592DOI 10.1016/J.DEVCEL.2010.01.007 Variant Set Distributions Mapped Variants
General Structure Information 1z0i RAB21 gdp-bound rab21 gtpase 2.33Å AUTH S.EATHIRAJ,X.PAN,C.RITACCO,D.G.LAMBRIGHTTITL STRUCTURAL BASIS OF FAMILY-WIDE RAB GTPASETITL 2 RECOGNITION BY RABENOSYN-5.REF NATURE V. 436 415 2005REFN ISSN 0028-0836PMID 16034420DOI 10.1038/NATURE03798 Variant Set Distributions Mapped Variants
General Structure Information 3p1j GIMAP2 crystal structure of human gtpase imap family member 2 in the nucleotide-free state 2.58Å AUTH L.SHEN,W.TEMPEL,Y.TONG,X.GUAN,L.NEDYALKOVA,A.K.WERNIMONT,AUTH 2 F.MACKENZIE,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,D.W.ANDREWS,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN GTPASE IMAP FAMILY MEMBER 2 INTITL 2 THE NUCLEOTIDE-FREE STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2qq8 TBC1D14 crystal structure of the putative rabgap domain of human tbc1 domain family member 14 2.0Å AUTH Y.TONG,W.TEMPEL,S.DIMOV,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE PUTATIVE RABGAP DOMAIN OFTITL 2 HUMAN TBC1 DOMAIN FAMILY MEMBER 14.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2ohf OLA1 crystal structure of human ola1 in complex with amppcp 2.7Å AUTH R.KOLLER-EICHHORN,T.MARQUARDT,R.GAIL,A.WITTINGHOFER,AUTH 2 D.KOSTREWA,U.KUTAY,C.KAMBACHTITL HUMAN OLA1 DEFINES AN ATPASE SUBFAMILY IN THE OBG FAMILY OFTITL 2 GTP-BINDING PROTEINSREF J.BIOL.CHEM. V. 282 19928 2007REFN ISSN 0021-9258PMID 17430889DOI 10.1074/JBC.M700541200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants