Assessment of Structural Intolerance and Durability
General Structure Information 3fn3 CD274 dimeric structure of pd-l1 2.7Å AUTH Y.CHEN,P.LIU,F.GAO,H.CHENG,J.QI,G.F.GAOTITL A DIMERIC STRUCTURE OF PD-L1: FUNCTIONAL UNITS ORTITL 2 EVOLUTIONARY RELICS?REF PROTEIN CELL V. 1 153 2010REFN ISSN 1674-800XPMID 21203985DOI 10.1007/S13238-010-0022-1 Variant Set Distributions Mapped Variants
General Structure Information 3b94 TNFSF18 crystal structure of human gitrl 2.5Å AUTH X.M.SONG,Z.C.ZHOU,M.I.GREENETITL CRYSTAL STRUCTURE OF HUMAN GITRLREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dzj TECR 2dzj/solution structure of the n-terminal ubiquitin-like domain in human synaptic glycoprotein sc2 -1.0Å AUTH C.ZHAO,M.YONEYAMA,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL 2DZJ/SOLUTION STRUCTURE OF THE N-TERMINALTITL 2 UBIQUITIN-LIKE DOMAIN IN HUMAN SYNAPTICTITL 3 GLYCOPROTEIN SC2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rjq ADAMTS5 crystal structure of adamts5 with inhibitor bound 2.6Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,T.MCDONAGH,AUTH 2 S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,E.L.REIFENBERG,AUTH 3 L.A.COLLINS-RACIE,C.CORCORAN,B.FREEMAN,R.ZOLLNER,T.MARVELL,AUTH 4 M.VERA,P.E.SUM,E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECAN DEGRADINGTITL 2 ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3lgg CECR1 crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ada2) complexed with transition state analogue, coformycin 2.5Å AUTH A.V.ZAVIALOV,X.YU,D.SPILLMANN,G.LAUVAU,A.V.ZAVIALOVTITL STRUCTURAL BASIS FOR THE GROWTH FACTOR ACTIVITY OF HUMANTITL 2 ADENOSINE DEAMINASE ADA2.REF J.BIOL.CHEM. V. 285 12367 2010REFN ISSN 0021-9258PMID 20147294DOI 10.1074/JBC.M109.083527 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3h5c SERPINA10 x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1pja PPT2 the crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (ppt1 and ppt2) 2.7Å AUTH G.CALERO,P.GUPTA,M.C.NONATO,S.TANDEL,E.R.BIEHL,S.L.HOFMANN,AUTH 2 J.CLARDYTITL THE CRYSTAL STRUCTURE OF PALMITOYL PROTEIN THIOESTERASE-2TITL 2 (PPT2) REVEALS THE BASIS FOR DIVERGENT SUBSTRATETITL 3 SPECIFICITIES OF THE TWO LYSOSOMAL THIOESTERASES, PPT1 […]
General Structure Information 3duh IL23A structure of interleukin-23 2.3Å AUTH P.J.LUPARDUS,K.C.GARCIATITL THE STRUCTURE OF INTERLEUKIN-23 REVEALS THE MOLECULAR BASISTITL 2 OF P40 SUBUNIT SHARING WITH INTERLEUKIN-12.REF J.MOL.BIOL. V. 382 931 2008REFN ISSN 0022-2836PMID 18680750DOI 10.1016/J.JMB.2008.07.051 Variant Set Distributions Mapped Variants
General Structure Information 3dlq IL22 crystal structure of the il-22/il-22r1 complex 1.9Å AUTH L.BLEICHER,P.R.DE MOURA,L.WATANABE,D.COLAU,AUTH 2 L.DUMOUTIER,J.-C.RENAULD,I.POLIKARPOVTITL CRYSTAL STRUCTURE OF THE IL-22/IL-22R1 COMPLEX ANDTITL 2 ITS IMPLICATIONS FOR THE IL-22 SIGNALING MECHANISMREF FEBS LETT. V. 582 2985 2008REFN ISSN 0014-5793PMID 18675809DOI 10.1016/J.FEBSLET.2008.07.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2k8p SOST characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of wnt-mediated bone formation -1.0Å AUTH V.VEVERKA,A.J.HENRY,P.M.SLOCOMBE,A.VENTOM,B.MULLOY,AUTH 2 F.W.MUSKETT,M.MUZYLAK,K.GREENSLADE,A.MOORE,L.ZHANG,AUTH 3 J.GONG,X.QIAN,C.PASZTY,R.J.TAYLOR,M.K.ROBINSON,AUTH 4 M.D.CARRTITL CHARACTERIZATION OF THE STRUCTURAL FEATURES ANDTITL 2 INTERACTIONS OF SCLEROSTIN: MOLECULAR INSIGHT INTOTITL 3 A KEY REGULATOR OF WNT-MEDIATED BONE FORMATIONREF J.BIOL.CHEM. […]