Assessment of Structural Intolerance and Durability
General Structure Information 2zns GRIK1 crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, glur5, in complex with glutamate 2.0Å AUTH M.UNNO,M.SHINOHARA,K.TAKAYAMA,H.TANAKA,K.TERUYA,K.DOH-URA,AUTH 2 R.SAKAI,M.SASAKI,M.IKEDA-SAITOTITL BINDING AND SELECTIVITY OF THE MARINE TOXIN NEODYSIHERBAINETITL 2 A AND ITS SYNTHETIC ANALOGUES TO GLUK1 AND GLUK2 KAINATETITL 3 RECEPTORS.REF J.MOL.BIOL. V. 413 667 2011REFN ISSN 0022-2836PMID […]
General Structure Information 3kvq KDR crystal structure of vegfr2 extracellular domain d7 2.7Å AUTH Y.YANG,P.XIE,Y.OPATOWSKY,J.SCHLESSINGERTITL DIRECT CONTACTS BETWEEN EXTRACELLULARTITL 2 MEMBRANE-PROXIMAL DOMAINS ARE REQUIRED FOR VEGFTITL 3 RECEPTOR ACTIVATION AND CELL SIGNALINGREF PROC.NATL.ACAD.SCI.USA V. 107 1906 2010REFN ISSN 0027-8424PMID 20080685DOI 10.1073/PNAS.0914052107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4bwe GPC1 crystal structure of c-terminally truncated glypican-1 after controlled dehydration to 86 percent relative humidity 2.46Å AUTH W.AWAD,G.SVENSSON BIRKEDAL,M.M.G.M.THUNNISSEN,K.MANI,AUTH 2 D.T.LOGANTITL IMPROVEMENTS OF THE ORDER, ISOTROPY AND ELECTRON DENSITY OFTITL 2 GLYPICAN-1 CRYSTALS BY CONTROLLED DEHYDRATIONREF ACTA CRYSTALLOGR.,SECT.D V. 69 2524 2013REFN ISSN 0907-4449PMID 24311593DOI 10.1107/S0907444913025250 Variant Set Distributions Ripley’s K […]
General Structure Information 2v5e GDNF the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding. 2.35Å AUTH V.PARKASH,V.-M.LEPPANEN,H.VIRTANEN,J.-M.JURVANSUU,AUTH 2 M.M.BESPALOV,Y.A.SIDOROVA,P.RUNEBERG-ROOS,M.SAARMA,AUTH 3 A.GOLDMANTITL THE STRUCTURE OF THE GLIAL CELL LINE-DERIVEDTITL 2 NEUROTROPHIC FACTOR-CORECEPTOR COMPLEX: INSIGHTSTITL 3 INTO RET SIGNALING AND HEPARIN BINDING.REF J.BIOL.CHEM. V. 283 35164 2008REFN ISSN 0021-9258PMID 18845535DOI 10.1074/JBC.M802543200 Variant Set […]
General Structure Information 3qwr IL12B crystal structure of il-23 in complex with an adnectin 3.25Å AUTH V.RAMAMURTHY,S.R.KRYSTEK,A.BUSH,A.WEI,S.L.EMANUEL,AUTH 2 R.DAS GUPTA,A.JANJUA,L.CHENG,M.MURDOCK,B.ABRAMCZYK,D.COHEN,AUTH 3 Z.LIN,P.MORIN,J.H.DAVIS,M.DABRITZ,D.C.MCLAUGHLIN,K.A.RUSSO,AUTH 4 G.CHAO,M.C.WRIGHT,V.A.JENNY,L.J.ENGLE,E.FURFINE,S.SHERIFFTITL STRUCTURES OF ADNECTIN/PROTEIN COMPLEXES REVEAL AN EXPANDEDTITL 2 BINDING FOOTPRINT.REF STRUCTURE V. 20 259 2012REFN ISSN 0969-2126PMID 22325775DOI 10.1016/J.STR.2011.11.016 Variant Set Distributions Mapped Variants
General Structure Information 2uur COL9A1 n-terminal nc4 domain of collagen ix 1.8Å AUTH V.-M.LEPPANEN,H.TOSSAVAINEN,P.PERMI,L.LEHTIO,AUTH 2 G.RONNHOLM,A.GOLDMAN,I.KILPELAINEN,T.PIHLAJAMAATITL CRYSTAL STRUCTURE OF THE N-TERMINAL NC4 DOMAIN OFTITL 2 COLLAGEN IX, A ZINC BINDING MEMBER OF THE LAMININ-TITL 3 NEUREXIN-SEX HORMONE BINDING GLOBULIN (LNS) DOMAINTITL 4 FAMILY.REF J.BIOL.CHEM. V. 282 23219 2007REFN ISSN 0021-9258PMID 17553797DOI 10.1074/JBC.M702514200 Variant Set Distributions […]
General Structure Information 3fe4 CA6 crystal structure of human carbonic anhydrase vi 1.9Å AUTH E.S.PILKA,G.KOCHAN,U.OPPERMANN,W.W.YUETITL CRYSTAL STRUCTURE OF THE SECRETORY ISOZYME OF MAMMALIANTITL 2 CARBONIC ANHYDRASES CA VI: IMPLICATIONS FOR BIOLOGICALTITL 3 ASSEMBLY AND INHIBITOR DEVELOPMENTREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 419 485 2012REFN ISSN 0006-291XPMID 22366092DOI 10.1016/J.BBRC.2012.02.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2r53 BMP6 crystal structure analysis of bone morphogenetic protein-6 variant b2 (b2-bmp-6) 2.1Å AUTH S.SAREMBA,J.NICKEL,A.SEHER,A.KOTZSCH,W.SEBALD,AUTH 2 T.D.MUELLERTITL TYPE I RECEPTOR BINDING OF BONE MORPHOGENETICTITL 2 PROTEIN 6 IS DEPENDENT ON N-GLYCOSYLATION OF THETITL 3 LIGAND.REF FEBS J. V. 275 172 2007REFN ISSN 1742-464XPMID 18070108DOI 10.1111/J.1742-4658.2007.06187.X Variant Set Distributions Mapped Variants
General Structure Information 2rbl TNC high resolution design of a protein loop 2.1Å AUTH X.HU,H.WANG,H.KE,B.KUHLMANTITL HIGH-RESOLUTION DESIGN OF A PROTEIN LOOP.REF PROC.NATL.ACAD.SCI.USA V. 104 17668 2007REFN ISSN 0027-8424PMID 17971437DOI 10.1073/PNAS.0707977104 Variant Set Distributions Mapped Variants
General Structure Information 2v5y PTPRM crystal structure of the receptor protein tyrosine phosphatase mu ectodomain 3.1Å AUTH A.R.ARICESCU,C.SIEBOLD,K.CHOUDHURI,V.T.CHANG,W.LU,S.J.DAVIS,AUTH 2 P.A.VAN DER MERWE,E.Y.JONESTITL STRUCTURE OF A TYROSINE PHOSPHATASE ADHESIVE INTERACTIONTITL 2 REVEALS A SPACER-CLAMP MECHANISM.REF SCIENCE V. 317 1217 2007REFN ISSN 0036-8075PMID 17761881DOI 10.1126/SCIENCE.1144646 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants