Assessment of Structural Intolerance and Durability
General Structure Information 1jsg TCL1A crystal structure of p14tcl1, an oncogene product involved in t-cell prolymphocytic leukemia, reveals a novel b- barrel topology 2.5Å AUTH F.HOH,Y.S.YANG,L.GUIGNARD,A.PADILLA,M.H.STERN,AUTH 2 J.M.LHOSTE,H.VAN TILBEURGHTITL CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCTTITL 2 INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA,TITL 3 REVEALS A NOVEL BETA-BARREL TOPOLOGY.REF STRUCTURE V. 6 147 1998REFN ISSN 0969-2126PMID […]
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]
General Structure Information 1iyj SHFM1 structure of a brca2-dss1 complex 3.4Å AUTH H.YANG,P.D.JEFFREY,J.MILLER,E.KINNUCAN,Y.SUN,AUTH 2 N.H.THOMA,N.ZHENG,P.L.CHEN,W.H.LEE,N.P.PAVLETICHTITL BRCA2 FUNCTION IN DNA BINDING AND RECOMBINATIONTITL 2 FROM A BRCA2-DSS1-SSDNA STRUCTURE.REF SCIENCE V. 297 1837 2002REFN ISSN 0036-8075PMID 12228710DOI 10.1126/SCIENCE.297.5588.1837 Variant Set Distributions Mapped Variants
General Structure Information 2leo SPINK7 solution structure of esophageal cancer-related gene 2 -1.0Å AUTH Y.FENG,Y.GENG,T.ZHOU,J.WANGTITL NMR STRUCTURE NOTE: HUMAN ESOPHAGEAL CANCER-RELATED GENE 2REF J.BIOMOL.NMR V. 53 65 2012REFN ISSN 0925-2738PMID 22528291DOI 10.1007/S10858-012-9622-9 Variant Set Distributions Mapped Variants
General Structure Information 1buo ZBTB16 btb domain from plzf 1.9Å AUTH K.F.AHMAD,C.K.ENGEL,G.G.PRIVETITL CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM PLZF.REF PROC.NATL.ACAD.SCI.USA V. 95 12123 1998REFN ISSN 0027-8424PMID 9770450DOI 10.1073/PNAS.95.21.12123 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1n0w RAD51 crystal structure of a rad51-brca2 brc repeat complex 1.7Å AUTH L.PELLEGRINI,D.S.YU,T.LO,S.ANAND,M.LEE,AUTH 2 T.L.BLUNDELL,A.R.VENKITARAMANTITL INSIGHTS INTO DNA RECOMBINATION FROM THE STRUCTURETITL 2 OF A RAD51-BRCA2 COMPLEXREF NATURE V. 420 287 2002REFN ISSN 0028-0836PMID 12442171DOI 10.1038/NATURE01230 Variant Set Distributions Mapped Variants
General Structure Information 1gzh TP53BP1 crystal structure of the brct domains of human 53bp1 bound to the p53 tumor supressor 2.6Å AUTH D.J.DERBYSHIRE,B.P.BASU,L.SERPELL,W.JOO,T.DATE,AUTH 2 K.IWABUCHI,A.J.DOHERTYTITL CRYSTAL STRUCTURE OF HUMAN 53BP1 BRCT DOMAINSTITL 2 BOUND TO P53 TUMOUR SUPPRESSORREF EMBO J. V. 21 3863 2002REFN ISSN 0261-4189PMID 12110597DOI 10.1093/EMBOJ/CDF383 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1jsg TCL1A crystal structure of p14tcl1, an oncogene product involved in t-cell prolymphocytic leukemia, reveals a novel b- barrel topology 2.5Å AUTH F.HOH,Y.S.YANG,L.GUIGNARD,A.PADILLA,M.H.STERN,AUTH 2 J.M.LHOSTE,H.VAN TILBEURGHTITL CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCTTITL 2 INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA,TITL 3 REVEALS A NOVEL BETA-BARREL TOPOLOGY.REF STRUCTURE V. 6 147 1998REFN ISSN 0969-2126PMID […]
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]
General Structure Information 1iyj SHFM1 structure of a brca2-dss1 complex 3.4Å AUTH H.YANG,P.D.JEFFREY,J.MILLER,E.KINNUCAN,Y.SUN,AUTH 2 N.H.THOMA,N.ZHENG,P.L.CHEN,W.H.LEE,N.P.PAVLETICHTITL BRCA2 FUNCTION IN DNA BINDING AND RECOMBINATIONTITL 2 FROM A BRCA2-DSS1-SSDNA STRUCTURE.REF SCIENCE V. 297 1837 2002REFN ISSN 0036-8075PMID 12228710DOI 10.1126/SCIENCE.297.5588.1837 Variant Set Distributions Mapped Variants