Assessment of Structural Intolerance and Durability
General Structure Information 3ks9 GRM1 metabotropic glutamate receptor mglur1 complexed with ly341495 antagonist 1.9Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITHTITL 2 LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hei RAB5B crystal structure of human rab5b in complex with gdp 1.55Å AUTH B.HONG,L.SHEN,J.WANG,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB5B IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ht6 GEM crystal structure of human gem g-domain bound to gdp 2.4Å AUTH Y.OPATOWSKY,Y.SASSON,I.SHAKED,Y.WARD,AUTH 2 O.CHOMSKY-HECHT,Y.LITVAK,Z.SELINGER,K.KELLY,AUTH 3 J.A.HIRSCHTITL STRUCTURE-FUNCTION STUDIES OF THE G-DOMAIN FROMTITL 2 HUMAN GEM, A NOVEL SMALL G-PROTEIN.REF FEBS LETT. V. 580 5959 2006REFN ISSN 0014-5793PMID 17052716DOI 10.1016/J.FEBSLET.2006.09.067 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3ks9 GRM1 metabotropic glutamate receptor mglur1 complexed with ly341495 antagonist 1.9Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITHTITL 2 LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hei RAB5B crystal structure of human rab5b in complex with gdp 1.55Å AUTH B.HONG,L.SHEN,J.WANG,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB5B IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ht6 GEM crystal structure of human gem g-domain bound to gdp 2.4Å AUTH Y.OPATOWSKY,Y.SASSON,I.SHAKED,Y.WARD,AUTH 2 O.CHOMSKY-HECHT,Y.LITVAK,Z.SELINGER,K.KELLY,AUTH 3 J.A.HIRSCHTITL STRUCTURE-FUNCTION STUDIES OF THE G-DOMAIN FROMTITL 2 HUMAN GEM, A NOVEL SMALL G-PROTEIN.REF FEBS LETT. V. 580 5959 2006REFN ISSN 0014-5793PMID 17052716DOI 10.1016/J.FEBSLET.2006.09.067 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2o52 RAB4B crystal structure of human rab4b in complex with gdp 2.2Å AUTH H.ZHU,W.TEMPEL,J.WANG,Y.SHEN,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB4B IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3q7q RRAD crystal structure of rad g-domain q148a-gtp analog complex 2.3Å AUTH Y.SASSON,L.NAVON-PERRY,D.HUPPERT,J.A.HIRSCHTITL RGK FAMILY G-DOMAIN:GTP ANALOG COMPLEX STRUCTURES ANDTITL 2 NUCLEOTIDE-BINDING PROPERTIES.REF J.MOL.BIOL. V. 413 372 2011REFN ISSN 0022-2836PMID 21903096DOI 10.1016/J.JMB.2011.08.017 Variant Set Distributions Mapped Variants
General Structure Information 2a72 RGS7 structure of the regulator of g-protein signaling domain of rgs7 2.0Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2qkh GIPR crystal structure of the extracellular domain of human gip receptor in complex with the hormone gip 1.9Å AUTH C.PARTHIER,M.KLEINSCHMIDT,P.NEUMANN,R.RUDOLPH,AUTH 2 S.MANHART,D.SCHLENZIG,J.FANGHANEL,J.-U.RAHFELD,AUTH 3 H.-U.DEMUTH,M.T.STUBBSTITL CRYSTAL STRUCTURE OF THE INCRETIN-BOUNDTITL 2 EXTRACELLULAR DOMAIN OF A G PROTEIN-COUPLEDTITL 3 RECEPTORREF PROC.NATL.ACAD.SCI.USA V. 104 13942 2007REFN ISSN 0027-8424PMID 17715056DOI 10.1073/PNAS.0706404104 Variant Set Distributions Ripley’s […]