Assessment of Structural Intolerance and Durability
General Structure Information 2il1 RAB12 crystal structure of a predicted human gtpase in complex with gdp 2.1Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF A PREDICTED HUMAN GTPASE IN COMPLEXTITL 2 WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4bst RSPO1 structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form 4.3Å AUTH W.C.PENG,W.DE LAU,F.FORNERIS,J.C.M.GRANNEMAN,M.HUCH,AUTH 2 H.CLEVERS,P.GROSTITL STRUCTURE OF STEM CELL GROWTH FACTOR R-SPONDIN 1 IN COMPLEXTITL 2 WITH THE ECTODOMAIN OF ITS RECEPTOR LGR5.REF CELL REP. V. 3 1885 2013REFN ISSN 2211-1247PMID 23809763DOI 10.1016/J.CELREP.2013.06.009 Variant […]
General Structure Information 1upt GOLGA4 structure of a complex of the golgin-245 grip domain with arl1 1.7Å AUTH B.PANIC,O.PERISIC,D.B.VEPRINTSEV,R.L.WILLIAMS,AUTH 2 S.MUNROTITL STRUCTURAL BASIS FOR ARL1-DEPENDENT TARGETING OFTITL 2 HOMODIMERIC GRIP DOMAINS TO THE GOLGI APPARATUSREF MOL.CELL V. 12 863 2003REFN ISSN 1097-2765PMID 14580338DOI 10.1016/S1097-2765(03)00356-3 Variant Set Distributions Mapped Variants
General Structure Information 3sm9 GRM3 crystal structure of metabotropic glutamate receptor 3 precursor in presence of ly341495 antagonist 2.26Å AUTH A.K.WERNIMONT,A.DONG,A.SEITOVA,L.CROMBET,G.KHUTORESKAYA,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,AUTH 3 E.DOBROVETSKYTITL CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR 3TITL 2 PRECURSOR IN PRESENCE OF LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2fg5 RAB31 crystal structure of human rab31 in complex with a gtp analogue 2.8Å AUTH J.WANG,W.TEMPEL,S.ISMAIL,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB31 IN COMPLEX WITH ATITL 2 GTP ANALOGUEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1grn ARHGAP1 crystal structure of the cdc42/cdc42gap/alf3 complex. 2.1Å AUTH N.NASSAR,G.R.HOFFMAN,D.MANOR,J.C.CLARDY,R.A.CERIONETITL STRUCTURES OF CDC42 BOUND TO THE ACTIVE ANDTITL 2 CATALYTICALLY COMPROMISED FORMS OF CDC42GAP.REF NAT.STRUCT.BIOL. V. 5 1047 1998REFN ISSN 1072-8368PMID 9846874DOI 10.1038/4156 Variant Set Distributions Mapped Variants
General Structure Information 1grn ARHGAP1 crystal structure of the cdc42/cdc42gap/alf3 complex. 2.1Å AUTH N.NASSAR,G.R.HOFFMAN,D.MANOR,J.C.CLARDY,R.A.CERIONETITL STRUCTURES OF CDC42 BOUND TO THE ACTIVE ANDTITL 2 CATALYTICALLY COMPROMISED FORMS OF CDC42GAP.REF NAT.STRUCT.BIOL. V. 5 1047 1998REFN ISSN 1072-8368PMID 9846874DOI 10.1038/4156 Variant Set Distributions Mapped Variants
General Structure Information 1grn ARHGAP1 crystal structure of the cdc42/cdc42gap/alf3 complex. 2.1Å AUTH N.NASSAR,G.R.HOFFMAN,D.MANOR,J.C.CLARDY,R.A.CERIONETITL STRUCTURES OF CDC42 BOUND TO THE ACTIVE ANDTITL 2 CATALYTICALLY COMPROMISED FORMS OF CDC42GAP.REF NAT.STRUCT.BIOL. V. 5 1047 1998REFN ISSN 1072-8368PMID 9846874DOI 10.1038/4156 Variant Set Distributions Mapped Variants
General Structure Information 4gnk PLCB3 crystal structure of galphaq in complex with full-length human plcbeta3 4.0Å AUTH A.M.LYON,S.DUTTA,C.A.BOGUTH,G.SKINIOTIS,J.J.TESMERTITL FULL-LENGTH G ALPHA (Q)-PHOSPHOLIPASE C-BETA 3 STRUCTURETITL 2 REVEALS INTERFACES OF THE C-TERMINAL COILED-COIL DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 20 355 2013REFN ISSN 1545-9993PMID 23377541DOI 10.1038/NSMB.2497 Variant Set Distributions Mapped Variants
General Structure Information 4gnk PLCB3 crystal structure of galphaq in complex with full-length human plcbeta3 4.0Å AUTH A.M.LYON,S.DUTTA,C.A.BOGUTH,G.SKINIOTIS,J.J.TESMERTITL FULL-LENGTH G ALPHA (Q)-PHOSPHOLIPASE C-BETA 3 STRUCTURETITL 2 REVEALS INTERFACES OF THE C-TERMINAL COILED-COIL DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 20 355 2013REFN ISSN 1545-9993PMID 23377541DOI 10.1038/NSMB.2497 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]